dbPTM

PNK1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PNK1_SCHPO
UniProt AC	O13911
Protein Name	Bifunctional polynucleotide phosphatase/kinase
Gene Name	pnk1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	408
Subcellular Localization	Nucleus .
Protein Description	Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA..
Protein Sequence	MSSKKRKSPPQESLTSYFEKSSKSSKKYGSQNKDSDSSSTCLQQKIEIQWSITDSLYIAKYGKLKKTKKFIAFDLDGTLIKTKSGRVFSKDAADWTWWHPSVVPKLKALYQDNYSLVIFSNQNGIPRKPSAGHTFQMKIRAIFESLDLPIVLYAAILKDKFRKPLTGMWNSFLKDVNRSIDLSFIKYVGDAAGRPGDHNSTDLKFAENIGIKFETPEQFFLGHSFVPPNFESFHPKNYLVRNSSSHPYHFKKSEHQEIVVLVGFPSSGKSTLAESQIVTQGYERVNQDILKTKSKCIKAAIEALKKEKSVVIDNTNPTIESRKMWIDIAQEFEIPIRCIHLQSSEELARHNNVFRYIHHNQKQLPEIAFNSFKSRFQMPTVEEGFTNVEEVPFKCLKDYEDTWNYWYE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
8	Phosphorylation	MSSKKRKSPPQESLT CCCCCCCCCCHHHHH	45.93	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PNK1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PNK1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PNK1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSE6_SCHPO	nse6	genetic	18931302
FHL1_SCHPO	fhl1	genetic	18931302
DAD2_SCHPO	dad2	genetic	18931302
HHP2_SCHPO	hhp2	genetic	18818364
ELP3_SCHPO	elp3	genetic	18818364
CTK1_SCHPO	lsk1	genetic	18818364
MED1_SCHPO	pmc2	genetic	18818364
ATP11_SCHPO	atp11	genetic	18818364
FEN1_SCHPO	rad2	genetic	18818364
SSU72_SCHPO	ssu72	genetic	18818364
PHD1_SCHPO	hos2	genetic	18818364
SRS2_SCHPO	srs2	genetic	18818364
NHP6_SCHPO	nhp6	genetic	18818364
GDIR_SCHPO	SPAC6F12.06	genetic	18818364
SPC34_SCHPO	spc34	genetic	18818364
MCL1_SCHPO	mcl1	genetic	18818364
REB1_SCHPO	reb1	genetic	18818364
SRB11_SCHPO	srb11	genetic	18818364
YG66_SCHPO	SPBC15C4.06c	genetic	18818364
PNPP_SCHPO	pho2	genetic	18818364
DENR_SCHPO	SPBC16C6.05	genetic	18818364
PAB2_SCHPO	pab2	genetic	18818364
RSC4_SCHPO	rsc4	genetic	18818364
NTO1_SCHPO	nto1	genetic	18818364
ELP5_SCHPO	elp5	genetic	18818364
SWD2_SCHPO	swd2	genetic	18818364
YH5D_SCHPO	SPBC215.13	genetic	18818364
BDC1_SCHPO	bdc1	genetic	18818364
ASK1_SCHPO	ask1	genetic	18818364
MYO51_SCHPO	myo51	genetic	18818364
MUB1_SCHPO	SPBC31F10.10c	genetic	18818364
TMA20_SCHPO	tma20	genetic	18818364
YJ03_SCHPO	rhn1	genetic	18818364
CLR4_SCHPO	clr4	genetic	18818364
RAD14_SCHPO	rhp14	genetic	18818364
TBA2_SCHPO	atb2	genetic	18818364
SUM2_SCHPO	sum2	genetic	18818364
RL16B_SCHPO	rpl1601	genetic	18818364
DHSD_SCHPO	sdh4	genetic	18818364
AIR1_SCHPO	air1	genetic	18818364
OCA2_SCHPO	oca2	genetic	18818364
RIK1_SCHPO	rik1	genetic	18818364
PP2C2_SCHPO	ptc2	genetic	18818364
HIF2_SCHPO	hif2	genetic	18818364
PUS1_SCHPO	pus1	genetic	18818364
BDF1_SCHPO	bdf1	genetic	18818364
MED19_SCHPO	rox3	genetic	18818364
MSH6_SCHPO	msh6	genetic	18818364
RL1DA_SCHPO	SPCC306.07c	genetic	18818364
CCR4_SCHPO	ccr4	genetic	18818364
MU154_SCHPO	mug154	genetic	18818364
SPP1_SCHPO	spf1	genetic	18818364
RAF1_SCHPO	raf1	genetic	18818364
BYE1_SCHPO	SPCC645.13	genetic	18818364
ELP2_SCHPO	elp2	genetic	18818364
RCD1_SCHPO	rcd1	genetic	18818364
SNF5_SCHPO	snf5	genetic	18818364
PTPA1_SCHPO	ypa1	genetic	18818364
TBCA_SCHPO	alp31	genetic	18818364
YKW3_SCHPO	bop1	genetic	18818364
H2AZ_SCHPO	pht1	genetic	18818364
PPIH_SCHPO	cyp3	genetic	18818364
YOU5_SCHPO	pph3	genetic	18818364
NGG1_SCHPO	ngg1	genetic	18818364
REC14_SCHPO	rec14	genetic	18818364
CLR3_SCHPO	clr3	genetic	18818364
DCN1_SCHPO	SPBC839.03c	genetic	18818364
UBP3_SCHPO	ubp3	genetic	18818364
URK1_SCHPO	SPCC162.11c	genetic	18818364
NUP61_SCHPO	nup61	genetic	18818364
SWC5_SCHPO	swc5	genetic	18818364
CID12_SCHPO	cid12	genetic	18818364
VPH2_SCHPO	vph2	genetic	18818364
KU70_SCHPO	pku70	genetic	22748672
APN2_SCHPO	apn2	genetic	22748672
NTH_SCHPO	nth1	genetic	22748672
TYDP1_SCHPO	tdp1	genetic	22748672
TPP1_SCHPO	tpp1	genetic	22681890
NSE6_SCHPO	nse6	genetic	22681890
YG58_SCHPO	SPBC56F2.08c	genetic	22681890
YD83_SCHPO	SPAC1F3.03	genetic	22681890
FHL1_SCHPO	fhl1	genetic	22681890
SVF1_SCHPO	SPCC584.11c	genetic	22681890
HAT1_SCHPO	hat1	genetic	22681890
FEN1_SCHPO	rad2	genetic	22681890
DPH3_SCHPO	dph3	genetic	22681890
BDC1_SCHPO	bdc1	genetic	22681890
YEG5_SCHPO	mga2	genetic	22681890
YKW2_SCHPO	SPAP32A8.02	genetic	22681890
PAC2_SCHPO	pac2	genetic	22681890
G3P2_SCHPO	gpd3	genetic	22681890
RTF2_SCHPO	rtf2	genetic	22681890
RFA3_SCHPO	ssb3	genetic	22681890
MED19_SCHPO	rox3	genetic	22681890
YJ03_SCHPO	rhn1	genetic	22681890
SNF30_SCHPO	snf30	genetic	22681890
MAK3_SCHPO	mak3	genetic	22681890
TRK1_SCHPO	trk1	genetic	22681890
ARF6_SCHPO	arf6	genetic	22681890
MEX67_SCHPO	mex67	genetic	22681890
REXO3_SCHPO	rex3	genetic	22681890
GOS1_SCHPO	gos1	genetic	22681890
DEP1_SCHPO	dep1	genetic	22681890
YPS1_SCHPO	yps1	genetic	22681890
ABC1_SCHPO	ybt1	genetic	22681890
NEM1_SCHPO	nem1	genetic	22681890
UAF30_SCHPO	spp27	genetic	22681890
YLO2_SCHPO	tma23	genetic	22681890
PNPP_SCHPO	pho2	genetic	22681890
APP1_SCHPO	abp1	genetic	22681890
YDA4_SCHPO	SPAC1F12.04c	genetic	22681890
SNF5_SCHPO	snf5	genetic	22681890
GCN5_SCHPO	gcn5	genetic	22681890
DYLT_SCHPO	dlc1	genetic	22681890
COM1_SCHPO	ctp1	genetic	22681890
PAB2_SCHPO	pab2	genetic	22681890
TMA20_SCHPO	tma20	genetic	22681890
RSC4_SCHPO	rsc4	genetic	22681890
ARP42_SCHPO	arp42	genetic	22681890
HHP2_SCHPO	hhp2	genetic	22681890
SPT2_SCHPO	spt2	genetic	22681890
YBPC_SCHPO	SPBC16H5.12c	genetic	22681890
PPK35_SCHPO	mug27	genetic	22681890
VPS38_SCHPO	vps38	genetic	22681890
SSN3_SCHPO	srb10	genetic	22681890
SOL1_SCHPO	sol1	genetic	22681890
MHF2_SCHPO	mhf2	genetic	22681890
YGK4_SCHPO	SPBC725.04	genetic	22681890
AROG_SCHPO	SPAP8A3.07c	genetic	22681890
CYB51_SCHPO	SPBC29A10.16c	genetic	22681890
YGVA_SCHPO	def1	genetic	22681890
ERFD_SCHPO	erf4	genetic	22681890
YQ9H_SCHPO	SPCC18.17c	genetic	22681890
MTG1_SCHPO	mtg1	genetic	22681890
RLA6_SCHPO	rpp203	genetic	22681890
MED1_SCHPO	pmc2	genetic	22681890
ASK1_SCHPO	ask1	genetic	22681890
RL17B_SCHPO	rpl1702	genetic	22681890
RPB9_SCHPO	rpb9	genetic	22681890
SUM2_SCHPO	sum2	genetic	22681890
MYH1_SCHPO	myh1	genetic	22681890
CGM2_SCHPO	mcs2	genetic	22681890
YAS5_SCHPO	mms1	genetic	22681890
YG0C_SCHPO	SPBC1604.12	genetic	22681890
MID1_SCHPO	mid1	genetic	22681890
SPM1_SCHPO	pmk1	genetic	22681890
QCR6_SCHPO	qcr6	genetic	22681890
PRZ1_SCHPO	prz1	genetic	22681890
CSK1_SCHPO	csk1	genetic	22681890
AREH2_SCHPO	are2	genetic	22681890
MKH1_SCHPO	mkh1	genetic	22681890
YBI8_SCHPO	oga1	genetic	22681890
UBP16_SCHPO	ubp16	genetic	22681890
APS1_SCHPO	aps1	genetic	22681890
YKK5_SCHPO	SPAC2E1P3.05c	genetic	22681890
YOX1_SCHPO	yox1	genetic	22681890
TCG1_SCHPO	tcg1	genetic	22681890
SLX9_SCHPO	slx9	genetic	22681890
SGF29_SCHPO	sgf29	genetic	22681890
RS4A_SCHPO	rps401	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PNK1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8, AND MASSSPECTROMETRY.	18257517 [Abstract]