| UniProt ID | SPT2_SCHPO | |
|---|---|---|
| UniProt AC | O94714 | |
| Protein Name | Protein spt2 | |
| Gene Name | spt2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 406 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Global regulatory protein that plays positive as well as negative regulatory roles in transcription.. | |
| Protein Sequence | MAGTPSFQKLMALADSQSAQAAVQIEQLRKAQIREKAREITEERNRQRKLQRERELRQKYEEEQRRQQAMEAKRIAASTRQTSERPPLSAEEAKRIREVKEKDRLESKKNERQGKPRSYNELLRQASSAPAVNETSSSGLLQSKDKRSQSPHSPKKPVKNSSSRDQPVRNSGATSTASLPPAGLRAGRGSQISASLAWLKTGGASAAPSNPRQPPPTSNFSNRKARYASNGLVQLQTGPKRDKRSAGEVQDEIMKRRQNSSISQAATPRTVSNSETSYVGSPALKQSKPNSLKSNNTSRKTSASSAITKPKARPHTSRHDEFVVSDDDELNDRVPDVSSEIWKIFGKRKQDYVSRDVFSDEDDMEATGHDVWREEQAAARAARLEDELEEQRERERELAKKRRKNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 148 | Phosphorylation | LQSKDKRSQSPHSPK CCCCCCCCCCCCCCC | 40.53 | 24763107 | |
| 150 | Phosphorylation | SKDKRSQSPHSPKKP CCCCCCCCCCCCCCC | 26.31 | 21712547 | |
| 153 | Phosphorylation | KRSQSPHSPKKPVKN CCCCCCCCCCCCCCC | 41.62 | 21712547 | |
| 277 | Phosphorylation | TVSNSETSYVGSPAL CCCCCCCCCCCCHHH | 17.48 | 29996109 | |
| 281 | Phosphorylation | SETSYVGSPALKQSK CCCCCCCCHHHHCCC | 9.28 | 29996109 | |
| 325 | Phosphorylation | RHDEFVVSDDDELND CCCCEECCCCHHHHH | 29.98 | 29996109 | |
| 359 | Phosphorylation | YVSRDVFSDEDDMEA HCCCCCCCCHHHHHH | 39.68 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPT2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPT2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPT2_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAF1_SCHPO | raf1 | genetic | 18818364 | |
| VPH2_SCHPO | vph2 | genetic | 18818364 | |
| IDHP_SCHPO | idp1 | genetic | 22681890 | |
| SWD3_SCHPO | swd3 | genetic | 22681890 | |
| DCUP_SCHPO | hem12 | genetic | 22681890 | |
| COM1_SCHPO | ctp1 | genetic | 22681890 | |
| PNK1_SCHPO | pnk1 | genetic | 22681890 | |
| JHD1_SCHPO | epe1 | genetic | 22681890 | |
| FFT3_SCHPO | fft3 | genetic | 22681890 | |
| DAD2_SCHPO | dad2 | genetic | 22681890 | |
| YJC7_SCHPO | SPCC736.07c | genetic | 22681890 | |
| UBP2_SCHPO | ubp2 | genetic | 22681890 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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