APN2_SCHPO - dbPTM
APN2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APN2_SCHPO
UniProt AC P87175
Protein Name DNA-(apurinic or apyrimidinic site) lyase 2
Gene Name apn2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 523
Subcellular Localization Nucleus .
Protein Description DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides the majority of the AP-endonuclease (APE) activity. Repairs phleomycin D1-induced DNA damage. Plays a role in oxidative damage repair..
Protein Sequence MRILSWNVNGIQNPFNYFPWNKKNSYKEIFQELQADVICVQELKMQKDSFPQQYAVVEGFDSYFTFPKIRKGYSGVGFYVKKDVAIPVKAEEGITGILPVRGQKYSYSEAPEHEKIGFFPKDIDRKTANWIDSEGRCILLDFQMFILIGVYCPVNSGENRLEYRRAFYKALRERIERLIKEGNRKIILVGDVNILCNPIDTADQKDIIRESLIPSIMESRQWIRDLLLPSRLGLLLDIGRIQHPTRKGMFTCWNTRLNTRPTNYGTRIDYTLATPDLLPWVQDADIMAEVMGSDHCPVYLDLKEEYEGKKLSNFLSHSKEPPLLSTAHHSAYRPSKNIHSMFQHFNSMKKNKNNSPTQSENVSASASSGSSPTVSRANSVIDVDAYPPEKRRRKEQSKLLSFFAKQKEEKEETNKTEDVSIEVLDNNNESDIGLTVKKKVENGNAWKQIFSERAPPLCEGHKEPCKYLTVRKPGINYGRKFWICARPVGELIKNSNAVSEEDTQPFQCRFFIWDSDWRANSKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
370PhosphorylationSASASSGSSPTVSRA
CCCCCCCCCCCCCCC		34.7829996109
371PhosphorylationASASSGSSPTVSRAN
CCCCCCCCCCCCCCC		28.2829996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APN2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APN2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APN2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRC1_SCHPObrc1genetic
17277362
MAG1_SCHPOmag1genetic
15722486
UVE1_SCHPOuve1genetic
14704348
TYDP1_SCHPOtdp1genetic
18818364
VPH2_SCHPOvph2genetic
18818364
NTH_SCHPOnth1genetic
22084197
TYDP1_SCHPOtdp1genetic
22084197
NTH_SCHPOnth1genetic
22748672
TYDP1_SCHPOtdp1genetic
22748672
NSE6_SCHPOnse6genetic
22681890
PFD5_SCHPObob1genetic
22681890
TYDP1_SCHPOtdp1genetic
22681890
RFA3_SCHPOssb3genetic
22681890
PPT1_SCHPOSPBC3F6.01cgenetic
22681890
PNK1_SCHPOpnk1genetic
22681890
PPK38_SCHPOppk38genetic
22681890
YH73_SCHPOSPBC16G5.03genetic
22681890
YAS5_SCHPOmms1genetic
22681890
SPN1_SCHPOspn1genetic
22681890
MYH1_SCHPOmyh1physical
24559510
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APN2_SCHPO

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Related Literatures of Post-Translational Modification

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