| UniProt ID | TYDP1_SCHPO | |
|---|---|---|
| UniProt AC | Q9USG9 | |
| Protein Name | Probable tyrosyl-DNA phosphodiesterase | |
| Gene Name | SPCP31B10.05 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 536 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).. | |
| Protein Sequence | MSTLEPEKRRQHEDKSNEIIDSPIFLNKISALPESENVHCLLLKQLIGSPQLKQTWQFNFCVDLNFLLENMHASVFPTVDVRITHGYDSKSDSLARLTAQMNHCPVNVKLYSVYVPMWGTHHSKIMVNFFKDDSCQIVIHTANLVEPDWIGMSQAIFKTPLLYPKANDSLSTSSVPEYGNPSKIRKHEGSLDIKDDRNCDIIDVDSAFENFKHKSDTRSSDDLGVIGRQFQQDFLAYLKNYRHTYELIEKLKMYDFSAIRAIFIGSVPGKFEGEEESSWGLGKLKKILKMLEKDSKKDEKTKFEESDICISQCSSMGSFGPKQEYIAELTDGFGCQRGNWKFLFPTVKEVQQSMLGWQSGSSIHFNILGKTAASQVETLKKGKNLCKWVAMKAGRQRVAPHIKTYMRFSNDGELLRWVLVTSANLSKPAWGTLEGHKAKSRSTRGLRIRSYEAGVLLYPKLFEESQRAPCIMTPTYKTNTPNLDEKRREFYGKRVIGVRMCWDFPPVEYEDKDEIWSPVINRTDKDWLGYVWPPNW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of TYDP1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TYDP1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TYDP1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TYDP1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YHHB_SCHPO | hmo1 | genetic | 18931302 | |
| SWI10_SCHPO | swi10 | genetic | 18931302 | |
| NSE5_SCHPO | nse5 | genetic | 18931302 | |
| NSE6_SCHPO | nse6 | genetic | 18931302 | |
| RAD60_SCHPO | rad60 | genetic | 21408210 | |
| SLX8_SCHPO | slx8 | genetic | 21408210 | |
| SWI10_SCHPO | swi10 | genetic | 21408210 | |
| TOP1_SCHPO | top1 | genetic | 21408210 | |
| RAD32_SCHPO | mre11 | genetic | 21408210 | |
| NTH_SCHPO | nth1 | genetic | 22084197 | |
| FEN1_SCHPO | rad2 | genetic | 22681890 | |
| PYP1_SCHPO | pyp1 | genetic | 22681890 | |
| MGR2_SCHPO | mgr2 | genetic | 22681890 | |
| GET1_SCHPO | get1 | genetic | 22681890 | |
| YCD2_SCHPO | pxd1 | genetic | 22681890 | |
| YLM6_SCHPO | SPAC19B12.06c | genetic | 22681890 | |
| TOP1_SCHPO | top1 | genetic | 25203555 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
