dbPTM

PYP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYP1_SCHPO
UniProt AC	P27574
Protein Name	Tyrosine-protein phosphatase 1
Gene Name	pyp1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	550
Subcellular Localization	Cytoplasm.
Protein Description	Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2..
Protein Sequence	MNFSNGSKSSTFTIAPSGSCIALPPQRGVATSKYAVHASCLQEYLDKEAWKDDTLIIDLRPVSEFSKSRIKGSVNLSLPATLIKRPAFSVARIISNLHDVDDKRDFQNWQEFSSILVCVPAWIANYVTNAEVIGEKFRKESYSGDFGILDLDYSKVSGKYPSVIDNSPVKSKLGALPSARPRLSYSAAQTAPISLSSEGSDYFSRPPPTPNVAGLSLNNFFCPLPENKDNKSSPFGSATVQTPCLHSVPDAFTNPDVATLYQKFLRLQSLEHQRLVSCSDRNSQWSTVDSLSNTSYKKNRYTDIVPYNCTRVHLKRTSPSELDYINASFIKTETSNYIACQGSISRSISDFWHMVWDNVENIGTIVMLGSLFEAGREMCTAYWPSNGIGDKQVYGDYCVKQISEENVDNSRFILRKFEIQNANFPSVKKVHHYQYPNWSDCNSPENVKSMVEFLKYVNNSHGSGNTIVHCSAGVGRTGTFIVLDTILRFPESKLSGFNPSVADSSDVVFQLVDHIRKQRMKMVQTFTQFKYVYDLIDSLQKSQVHFPVLT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
237	Phosphorylation	NKSSPFGSATVQTPC CCCCCCCCCCCCCCC	22.58	21712547
239	Phosphorylation	SSPFGSATVQTPCLH CCCCCCCCCCCCCCC	18.16	29996109
242	Phosphorylation	FGSATVQTPCLHSVP CCCCCCCCCCCCCCC	16.19	29996109
247	Phosphorylation	VQTPCLHSVPDAFTN CCCCCCCCCCCCCCC	23.54	29996109
253	Phosphorylation	HSVPDAFTNPDVATL CCCCCCCCCHHHHHH	47.78	29996109
317	Phosphorylation	TRVHLKRTSPSELDY CEEEEECCCHHHCCE	43.32	24763107
318	Phosphorylation	RVHLKRTSPSELDYI EEEEECCCHHHCCEE	30.38	28889911
320	Phosphorylation	HLKRTSPSELDYINA EEECCCHHHCCEEEE	51.03	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PYP1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PYP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2C1_SCHPO	ptc1	genetic	9211944
PP2C3_SCHPO	ptc3	genetic	9211944
HOG1_SCHPO	sty1	genetic	7501024
PYP2_SCHPO	pyp2	genetic	1448087
WEE1_SCHPO	wee1	genetic	1448087
CDK1_SCHPO	cdc2	genetic	1448087
PYP2_SCHPO	pyp2	genetic	1464319
HOG1_SCHPO	sty1	physical	10398679
WEE1_SCHPO	wee1	physical	8256510
KLP8_SCHPO	klp8	genetic	18931302
COX19_SCHPO	SPCC1672.04c	genetic	22681890
RIK1_SCHPO	rik1	genetic	22681890
MPH1L_SCHPO	mph1	genetic	22681890
TPP1_SCHPO	tpp1	genetic	22681890
AMPD_SCHPO	ada1	genetic	22681890
PEX1_SCHPO	pex1	genetic	22681890
MEI2_SCHPO	mei2	genetic	22681890
YG58_SCHPO	SPBC56F2.08c	genetic	22681890
HS104_SCHPO	hsp104	genetic	22681890
TAL1_SCHPO	tal1	genetic	22681890
DI3L2_SCHPO	dis32	genetic	22681890
YHZ8_SCHPO	SPBC21B10.08c	genetic	22681890
PPK33_SCHPO	ppk33	genetic	22681890
FIS1_SCHPO	fis1	genetic	22681890
SSR3_SCHPO	ssr3	genetic	22681890
ALY2_SCHPO	SPBC2D10.04	genetic	22681890
CDA1_SCHPO	cda1	genetic	22681890
SDS23_SCHPO	sds23	genetic	22681890
ILVB_SCHPO	ilv1	genetic	22681890
YI35_SCHPO	toe1	genetic	22681890
SCK1_SCHPO	sck1	genetic	22681890
DPH3_SCHPO	dph3	genetic	22681890
ADG2_SCHPO	adg2	genetic	22681890
BDC1_SCHPO	bdc1	genetic	22681890
YEG5_SCHPO	mga2	genetic	22681890
6PGL_SCHPO	SPCC16C4.10	genetic	22681890
YN1B_SCHPO	SPBC577.11	genetic	22681890
GPD1_SCHPO	gpd1	genetic	22681890
YI81_SCHPO	SPAPJ695.01c	genetic	22681890
YM06_SCHPO	SPAC212.06c	genetic	22681890
TYDP1_SCHPO	tdp1	genetic	22681890
MYO51_SCHPO	myo51	genetic	22681890
RAV2_SCHPO	rav2	genetic	22681890
ERFB_SCHPO	erf2	genetic	22681890
YAUE_SCHPO	SPAC26A3.14c	genetic	22681890
IMA3_SCHPO	SPCC550.11	genetic	22681890
SPN3_SCHPO	spn3	genetic	22681890
RNC1_SCHPO	rnc1	genetic	22681890
PSO2_SCHPO	pso2	genetic	22681890
YDEA_SCHPO	nod1	genetic	22681890
TRK1_SCHPO	trk1	genetic	22681890
YN8E_SCHPO	SPBP35G2.14	genetic	22681890
UBP8_SCHPO	ubp8	genetic	22681890
YAC5_SCHPO	cph1	genetic	22681890
AP2M_SCHPO	apm4	genetic	22681890
DBR1_SCHPO	dbr1	genetic	22681890
LEUC_SCHPO	leu2	genetic	22681890
YF69_SCHPO	SPAC23C4.09c	genetic	22681890
UBC16_SCHPO	ubc16	genetic	22681890
YK82_SCHPO	bdf2	genetic	22681890
WTF21_SCHPO	wtf21	genetic	22681890
CLR4_SCHPO	clr4	genetic	22681890
YBN2_SCHPO	SPBC8E4.02c	genetic	22681890
YGRG_SCHPO	SPBC365.16	genetic	22681890
MBO1_SCHPO	mto1	genetic	22681890
DAD1_SCHPO	dad1	genetic	22681890
YC1B_SCHPO	msy1	genetic	22681890
YDE9_SCHPO	pet801	genetic	22681890
AATC_SCHPO	SPAC10F6.13c	genetic	22681890
MET10_SCHPO	SPCC584.01c	genetic	22681890
SWD1_SCHPO	swd1	genetic	22681890
YG03_SCHPO	SPBC1604.03c	genetic	22681890
PPK4_SCHPO	ire1	genetic	22681890
ADDH_SCHPO	SPBC1289.14	genetic	22681890
MUG80_SCHPO	mug80	genetic	22681890
LAG1_SCHPO	lag1	genetic	22681890
YL85_SCHPO	deg1	genetic	22681890
WIS4_SCHPO	wis4	genetic	22681890
PPK30_SCHPO	ppk30	genetic	22681890
PPR5_SCHPO	ppr5	genetic	22681890
ERG5_SCHPO	erg5	genetic	22681890
NAGS_SCHPO	arg6	genetic	22681890
NAA35_SCHPO	mak10	genetic	22681890
BCA1_SCHPO	eca39	genetic	22681890
FCF2_SCHPO	fcf2	genetic	22681890
ASH2_SCHPO	ash2	genetic	22681890
MSA1_SCHPO	msa1	genetic	22681890
RL43B_SCHPO	rpl4302	genetic	22681890
SUMT_SCHPO	SPCC1739.06c	genetic	22681890
HIS2_SCHPO	his7	genetic	22681890
HOSM_SCHPO	lys4	genetic	22681890
GPDM_SCHPO	gut2	genetic	22681890
RL24B_SCHPO	rpl2402	genetic	22681890
GBB_SCHPO	git5	genetic	22681890
MUG2_SCHPO	mug2	genetic	22681890
YOOH_SCHPO	SPBC887.17	genetic	22681890
SCS7_SCHPO	scs7	genetic	22681890
TLS1_SCHPO	tls1	genetic	22681890
YKT4_SCHPO	SPAPB1E7.04c	genetic	22681890
SNT2_SCHPO	snt2	genetic	22681890
COQ10_SCHPO	coq10	genetic	22681890
PMP1_SCHPO	pmp1	genetic	22681890
PP2C3_SCHPO	ptc3	genetic	22681890
YJD1_SCHPO	SPCC594.01	genetic	22681890
MMS19_SCHPO	mms19	genetic	22681890
YFM8_SCHPO	SPAC222.08c	genetic	22681890
YO48_SCHPO	SPBC36B7.08c	genetic	22681890
YBLC_SCHPO	SPBC106.12c	genetic	22681890
RHO2_SCHPO	rho2	genetic	22681890
RM39_SCHPO	mrpl39	genetic	22681890
FRP1_SCHPO	frp1	genetic	22681890
YO88_SCHPO	SPBC21D10.08c	genetic	22681890
ATP5E_SCHPO	atp15	genetic	22681890
YB35_SCHPO	SPBC2F12.05c	genetic	22681890
YCF8_SCHPO	SPCC1393.08	genetic	22681890
FKBP4_SCHPO	fkbp39	genetic	22681890
ADN2_SCHPO	adn2	genetic	22681890
YOND_SCHPO	SPBC1105.13c	genetic	22681890
UBP3_SCHPO	ubp3	genetic	22681890
PYRD_SCHPO	ura3	genetic	22681890
ELP1_SCHPO	elp1	genetic	22681890
CYSK_SCHPO	cys11	genetic	22681890
CLR3_SCHPO	clr3	genetic	22681890
YH7H_SCHPO	SPBC16G5.17	genetic	22681890
PDT1_SCHPO	pdt1	genetic	22681890
SERA_SCHPO	ser3	genetic	22681890
ISH1_SCHPO	ish1	genetic	22681890
YGI7_SCHPO	hpz1	genetic	22681890
TGCE3_SCHPO	SPBC14C8.15	genetic	22681890
YJ53_SCHPO	SPCC4F11.03c	genetic	22681890
RL27A_SCHPO	rpl2701	genetic	22681890
YE87_SCHPO	SPAC9G1.07	genetic	22681890
H2A1_SCHPO	hta1	genetic	22681890
SET1_SCHPO	set1	genetic	22681890
CTK3_SCHPO	lsg1	genetic	22681890
RENT1_SCHPO	upf1	genetic	22681890
TSR4_SCHPO	SPBC25H2.15	genetic	22681890
YBPD_SCHPO	SPBC16H5.13	genetic	22681890
YQ9A_SCHPO	SPCC18.10	genetic	22681890
YI75_SCHPO	SPAC977.05c	genetic	22681890
ETFA_SCHPO	etf1	genetic	22681890
SPEB2_SCHPO	SPBC8E4.03	genetic	22681890
YAM5_SCHPO	mso1	genetic	22681890
RDS1_SCHPO	rds1	genetic	22681890
YFY7_SCHPO	SPAC9.07c	genetic	22681890
VPS20_SCHPO	vps20	genetic	22681890
DPH5_SCHPO	dph5	genetic	22681890
YB64_SCHPO	SPBC12C2.04	genetic	22681890
FFT3_SCHPO	fft3	genetic	22681890
PUC1_SCHPO	puc1	genetic	22681890
RL17B_SCHPO	rpl1702	genetic	22681890
RS4B_SCHPO	rps402	genetic	22681890
YHD3_SCHPO	SPBC1683.03c	genetic	22681890
YCPE_SCHPO	trp663	genetic	22681890
YK1D_SCHPO	SPAPB1A10.13	genetic	22681890
POF15_SCHPO	pof15	genetic	22681890
LTN1_SCHPO	rkr1	genetic	22681890
YA99_SCHPO	SPAC13G6.09	genetic	22681890
GAL1_SCHPO	gal1	genetic	22681890
MDM31_SCHPO	mdm31	genetic	22681890
HOP1_SCHPO	hop1	genetic	22681890
TBA2_SCHPO	atb2	genetic	22681890
IMA2_SCHPO	imp1	genetic	22681890
YG0C_SCHPO	SPBC1604.12	genetic	22681890
MID1_SCHPO	mid1	genetic	22681890
MU154_SCHPO	mug154	genetic	22681890
YG41_SCHPO	cxr1	genetic	22681890
RL9A_SCHPO	rpl901	genetic	22681890
PRS10_SCHPO	rpt4	genetic	22681890
MPC1_SCHPO	mpc1	genetic	22681890
YOM1_SCHPO	SPBPB7E8.01	genetic	22681890
PIL2_SCHPO	pil2	genetic	22681890
PRZ1_SCHPO	prz1	genetic	22681890
CSK1_SCHPO	csk1	genetic	22681890
WTF6_SCHPO	wtf6	genetic	22681890
YBOH_SCHPO	SPBC2G2.17c	genetic	22681890
MKH1_SCHPO	mkh1	genetic	22681890
CTU1_SCHPO	ctu1	genetic	22681890
CLR1_SCHPO	clr1	genetic	22681890
YKEE_SCHPO	SPAC1805.14	genetic	22681890
RS10A_SCHPO	rps1001	genetic	22681890
YNT3_SCHPO	SPBC9B6.03	genetic	22681890
RGA8_SCHPO	rga8	genetic	22681890
YHY1_SCHPO	mni1	genetic	22681890
WIS1_SCHPO	wis1	genetic	9321395
HOG1_SCHPO	sty1	physical	7501024
PHX1_SCHPO	phx1	genetic	25102102
TNR3_SCHPO	tnr3	physical	26771498
SEC6_SCHPO	sec6	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PYP1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-320, ANDMASS SPECTROMETRY.	18257517 [Abstract]