dbPTM

PDT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDT1_SCHPO
UniProt AC	Q10177
Protein Name	Manganese transporter pdt1
Gene Name	pdt1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	521
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Transports manganese ions into the cell. Regulates cell morphogenesis through control of manganese homeostasis..
Protein Sequence	MSSQSYYMNDLDDLRSLESSTLNKKDTAINELNPEQNDTRRSTDLLLEDKYGIQTGFSKYWKKCTYGIREYCKFIGPGFLIAVAYIDPGNYSTDLDAGSRFQYKLLFIVFLSNLFAVYLQSLCIRLGSVTGMDLARNCREHYNRYICWSFYVLAEIAIIATDIAEVIGTAVALKILMHIPLVAGVVITILDVLLVLIAWRPEGSMLSVRIFETAVALLVLVVAISFAVVLGRVHIGGAGTVFKGFLPSSTVFSREGLYSSIGILGATVMPHSLFLGSGLVQTRLRDLDVRRGNYTPVGDCSDYRPTHETIKHSLTYSIVEVALSLFTFALFTNSSILIVAGAVFYNTSGADTSDLFSIYDLLKEYVSISCGRLFAVALLFSGMSAGYVCTIAGQIVSEGYINWNLRPWLRRVITRAIAIIPCLVVSAAVGQSGLNQVLNASQVCLSILLPFLTFPLVMFTCSRKVMRVVSDSTNEETGQLIRETHDYSLGWTMTIVTWAIWLFLTALNLLLIVWLGMGVSF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	NDLDDLRSLESSTLN CCHHHHHHHHHHCCC	43.73	21712547
19	Phosphorylation	DDLRSLESSTLNKKD HHHHHHHHHCCCHHH	33.64	21712547
20	Phosphorylation	DLRSLESSTLNKKDT HHHHHHHHCCCHHHH	27.78	21712547
21	Phosphorylation	LRSLESSTLNKKDTA HHHHHHHCCCHHHHH	43.56	21712547
27	Phosphorylation	STLNKKDTAINELNP HCCCHHHHHHHHCCH	38.01	21712547
39	Phosphorylation	LNPEQNDTRRSTDLL CCHHHCCCHHHHHHH	35.22	21712547
42	Phosphorylation	EQNDTRRSTDLLLED HHCCCHHHHHHHHHH	24.00	28889911
43	Phosphorylation	QNDTRRSTDLLLEDK HCCCHHHHHHHHHHH	28.93	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PDT1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDT1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PDT1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDT1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-43, AND MASSSPECTROMETRY.	18257517 [Abstract]