SCK1_SCHPO - dbPTM
SCK1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCK1_SCHPO
UniProt AC P50530
Protein Name Serine/threonine-protein kinase sck1
Gene Name sck1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 696
Subcellular Localization
Protein Description Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Required for trehalase activation..
Protein Sequence MTEIFGKLHRSSNSENTNQASPSTIQSHSTQPVLSNDHSTKVNDYEGKEGASSNGYDPVFMSDRMKMRYNEITAQLHKEQSLKEDKESGSNSSESNGITPMGTYSEKPKLLQSRTPPSSCYIRHDTVVPKDKNGQHAFGRLYVRLHQGRDLNVKSVNAQPYAVITFEKTQVMVPPPFKDIDGGIPISIPSKNRPLAGSASGSSSGLHSELMLADVRCPHWDFETVFDVTKMKSQMVVSVYDKYEDDKFLGSVKITPIFLHEYVQEAWYKLEPLDLTKSLEGEIKVETIYEHIEHVRYGPEDFTALRLIGKGTFGQVYLVRKNDTNRIYAMKKISKKLIVRKKEVTHTLGERNILVRTSLDESPFIVGLKFSFQTASDLYLITDYMSGGELFWHLQHEGRFPEQRAKFYIAELVLALEHLHKHDIIYRDLKPENILLDADGHIALCDFGLSKANLSANATTNTFCGTTEYLAPEVLLEDKGYTKQVDFWSLGVLVFEMCCGWSPFYAPDVQQMYRNIAFGKVRFPKGVLSSEGRSFVRGLLNRNPNHRLGAVADTTELKEHPFFADINWDLLSKKKVQPPFKPNVQNDLDVSNFDKEFTNTNVKNINIVSNVDPANASTPLSNTIQDRFRGFTFVNKSIDEQFQNLGLQENEETDNLHACRTTTHSSVNSINSHGNPRTVDANDPVADTVFGETFEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationIFGKLHRSSNSENTN
HHHHHCCCCCCCCCC		24.1125720772
12PhosphorylationFGKLHRSSNSENTNQ
HHHHCCCCCCCCCCC		44.3129996109
14PhosphorylationKLHRSSNSENTNQAS
HHCCCCCCCCCCCCC		33.8829996109
17PhosphorylationRSSNSENTNQASPST
CCCCCCCCCCCCCHH		25.3428889911
21PhosphorylationSENTNQASPSTIQSH
CCCCCCCCCHHHHCC		15.0425720772
113PhosphorylationEKPKLLQSRTPPSSC
CCCCHHCCCCCCCCC		37.7821712547
115PhosphorylationPKLLQSRTPPSSCYI
CCHHCCCCCCCCCEE		44.8128889911
198PhosphorylationKNRPLAGSASGSSSG
CCCCCCCCCCCCCCC		17.4129996109
200PhosphorylationRPLAGSASGSSSGLH
CCCCCCCCCCCCCCC		40.6929996109
202PhosphorylationLAGSASGSSSGLHSE
CCCCCCCCCCCCCCC		20.8825720772
203PhosphorylationAGSASGSSSGLHSEL
CCCCCCCCCCCCCCE		31.7625720772
204PhosphorylationGSASGSSSGLHSELM
CCCCCCCCCCCCCEE		47.2529996109
208PhosphorylationGSSSGLHSELMLADV
CCCCCCCCCEEECCC		37.1529996109
345PhosphorylationIVRKKEVTHTLGERN
EECCHHHEEEECCCC		15.3829996109
347PhosphorylationRKKEVTHTLGERNIL
CCHHHEEEECCCCEE		27.3929996109
462PhosphorylationSANATTNTFCGTTEY
CCCCCCCCCCCCHHE		20.4329996109
466PhosphorylationTTNTFCGTTEYLAPE
CCCCCCCCHHEECCH		20.0329996109
467PhosphorylationTNTFCGTTEYLAPEV
CCCCCCCHHEECCHH		14.1229996109
617PhosphorylationNVDPANASTPLSNTI
CCCCCCCCCCCCHHH		30.3021712547
618PhosphorylationVDPANASTPLSNTIQ
CCCCCCCCCCCHHHH		26.3229996109
621PhosphorylationANASTPLSNTIQDRF
CCCCCCCCHHHHHHH		32.8821712547
623PhosphorylationASTPLSNTIQDRFRG
CCCCCCHHHHHHHHC		19.3521712547
632PhosphorylationQDRFRGFTFVNKSID
HHHHHCCEEECCCHH		29.5128889911
637PhosphorylationGFTFVNKSIDEQFQN
CCEEECCCHHHHHHH		30.0225720772
661PhosphorylationDNLHACRTTTHSSVN
CCCEECCCCCCCCHH		35.6125720772
663PhosphorylationLHACRTTTHSSVNSI
CEECCCCCCCCHHCC		21.1025720772
665PhosphorylationACRTTTHSSVNSINS
ECCCCCCCCHHCCCC		33.6128889911
666PhosphorylationCRTTTHSSVNSINSH
CCCCCCCCHHCCCCC		20.0829996109
669PhosphorylationTTHSSVNSINSHGNP
CCCCCHHCCCCCCCC		22.4629996109
672PhosphorylationSSVNSINSHGNPRTV
CCHHCCCCCCCCCCC		30.9725720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCK1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCK1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCK1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAPB_SCHPOpka1genetic
7498728
SCK2_SCHPOsck2genetic
9560431
WIS4_SCHPOwis4physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCK1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-632 AND SER-665, ANDMASS SPECTROMETRY.

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