WIS4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIS4_SCHPO
• UniProt AC: O14299
• Protein Name: MAP kinase kinase kinase wis4
• Gene Name: wis4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1401
• Protein Description: Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation..
• Protein Sequence: MGLEHTFYPAEDRFEPLLEHSEPVNFVPKENAKSYVRQGFASPHQSLMDNLVDSTESTKRSENFVSHIPLTPSHSGQSEKLMSTRTSHSPYISPTMSYTNHSPANLTRNSSFNHQHYSTTLRSPPSMRGRGIDVNSSHYPHISRPRTSSDSQKMYTRAPVDYYYIQENPYFNNIDQDSISDKSLPSTNQSLHHSEEDTESDNDFSESIHPEFDIDVFYKVSNILYDESDLQDPEKRERLEWHSMLSSVLKGDVMQTEKRRLRLTEPDGHSGTYISEVWLGLQAWLHGRLNADQAEVIRKSREGVEPVLREVIDFQIQDEETTKPPLEQVTEILEKVEQCKQFYISSREMEENVPLSASKEFNYKLNALISWSNVMESIQVETLVLQKWVGNDEFDLTMRTPQFNYDGVENTSSFVERIFRQSGLQRTFEQRTLTTLNRIIHQAKQTISENAQAFEEMKLPTYEDKLLPLVRFPIKLLEEALRLRLAYAKKIKGPNFLIVDSMLDDFKIALSVAVRIKREYIKIASPSPGWSLPTNVDEDYDNVLLDSLKFYFKLLTLKLSSGNKNLYFKEIDFLENEWAFLNEHIYWINGGDIHMAGQFSYLSNSLLLNVHRYVESHLNGPTERTAASLTNWYSTLLKNTQIRFRKILRFSETLNSRFENASDFVISEGHLPDLVNRLSTTGHFLAYTANLERDGVFVIADHTLSENPEALKALLFSKDISNLETIQQNCSYVLILCPVHPIVWKGRIEKVDVPDFSVDLKTNRVRIIASNKREHLQAAKSVFQSISGDLVTLAVECRSSITRVYKEFIRLSKLCMRISSTVVDCVSAVREACSGVNCHDLIYHVFSFAAEFGQRILRFLSFDSYWQTKLKRKITSLAVEWISFICDECDLMDRKTFRWGVGALEFLMLMIRGNNILLIDDAMFLKIREKVGKSMAFLLTHFDVLGAKSKVAAKLQRESTEVSSSPRLTSFGDVEEEALSIQLLQKETMLRIDELEIERNNTLLERLAIGHVLDDSVFRNRDFIKLASSFSNITIRWQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTIITMPPATITKKTSLSHTITEEKTAQLLAGRHDDSKAETDSLAASYKEESALPVASNVGLRQPNELRIDSINLPPAIVTPDTINYSVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	YVRQGFASPHQSLMD HHHHCCCCCCHHHHH	22.21	28889911
46	Phosphorylation	GFASPHQSLMDNLVD CCCCCCHHHHHHHHC	23.72	27738172
66	Phosphorylation	KRSENFVSHIPLTPS CCCCCCCCCCCCCCC	16.15	29996109
71	Phosphorylation	FVSHIPLTPSHSGQS CCCCCCCCCCCCCCC	19.86	28889911
73	Phosphorylation	SHIPLTPSHSGQSEK CCCCCCCCCCCCCCC	25.67	21712547
75	Phosphorylation	IPLTPSHSGQSEKLM CCCCCCCCCCCCCCC	42.75	28889911
78	Phosphorylation	TPSHSGQSEKLMSTR CCCCCCCCCCCCCCC	39.98	21712547
86	Phosphorylation	EKLMSTRTSHSPYIS CCCCCCCCCCCCCCC	30.77	25720772
89	Phosphorylation	MSTRTSHSPYISPTM CCCCCCCCCCCCCCC	21.11	25720772
91	Phosphorylation	TRTSHSPYISPTMSY CCCCCCCCCCCCCCC	19.62	25720772
93	Phosphorylation	TSHSPYISPTMSYTN CCCCCCCCCCCCCCC	14.42	29996109
95	Phosphorylation	HSPYISPTMSYTNHS CCCCCCCCCCCCCCC	16.38	29996109
99	Phosphorylation	ISPTMSYTNHSPANL CCCCCCCCCCCCCCC	21.10	29996109
102	Phosphorylation	TMSYTNHSPANLTRN CCCCCCCCCCCCCCC	27.98	29996109
110	Phosphorylation	PANLTRNSSFNHQHY CCCCCCCCCCCCCCC	32.77	25720772
111	Phosphorylation	ANLTRNSSFNHQHYS CCCCCCCCCCCCCCC	33.35	28889911
170	Phosphorylation	YYIQENPYFNNIDQD EEECCCCCCCCCCCC	30.44	21712547
180	Phosphorylation	NIDQDSISDKSLPST CCCCCCCCCCCCCCC	42.83	21712547
959	Phosphorylation	AAKLQRESTEVSSSP HHHHHHHCCCCCCCC	31.86	25720772
965	Phosphorylation	ESTEVSSSPRLTSFG HCCCCCCCCCCCCCC	13.41	25720772
1002	Phosphorylation	LEIERNNTLLERLAI HHHHCCCCHHHHHHH	35.95	18257517
1326	Phosphorylation	PATITKKTSLSHTIT CCCCCCCCCCCEECC	36.13	21712547
1327	Phosphorylation	ATITKKTSLSHTITE CCCCCCCCCCEECCH	36.43	25720772
1329	Phosphorylation	ITKKTSLSHTITEEK CCCCCCCCEECCHHH	20.53	25720772
1331	Phosphorylation	KKTSLSHTITEEKTA CCCCCCEECCHHHHH	26.64	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIS4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIS4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIS4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIS1_SCHPO	wis1	physical	9718372
WIS1_SCHPO	wis1	physical	9321395
WIN1_SCHPO	win1	genetic	20729203
BYR2_SCHPO	byr2	genetic	20729203
MKH1_SCHPO	mkh1	genetic	20729203
MCS4_SCHPO	mcs4	physical	20946853
PYP1_SCHPO	pyp1	genetic	16087744
PYP1_SCHPO	pyp1	genetic	22912829
WIN1_SCHPO	win1	genetic	23389634
WIN1_SCHPO	win1	physical	23389634
MCS4_SCHPO	mcs4	physical	23389634
WIS4_SCHPO	wis4	physical	23695164
MCS4_SCHPO	mcs4	physical	23695164
MPR1_SCHPO	mpr1	physical	23695164
WIN1_SCHPO	win1	genetic	26108447
WIS4_SCHPO	wis4	physical	26771498
MPR1_SCHPO	mpr1	physical	26771498
MCS4_SCHPO	mcs4	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.