WIS1_SCHPO - dbPTM
WIS1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WIS1_SCHPO
UniProt AC P33886
Protein Name Protein kinase wis1
Gene Name wis1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 605
Subcellular Localization
Protein Description Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1..
Protein Sequence MSSPNNQPLSCSLRQLSISPTAPPGDVGTPGSLLSLSSSSSSNTDSSGSSLGSLSLNSNSSGSDNDSKVSSPSREIPSDPPLPRAVPTVRLGRSTSSRSRNSLNLDMKDPSEKPRRSLPTAAGQNNIGSPPTPPGPFPGGLSTDIQEKLKAFHASRSKSMPEVVNKISSPTTPIVGMGQRGSYPLPNSQLAGRLSNSPVKSPNMPESGLAKSLAAARNPLLNRPTSFNRQTRIRRAPPGKLDLSNSNPTSPVSPSSMASRRGLNIPPTLKQAVSETPFSTFSDILDAKSGTLNFKNKAVLNSEGVNFSSGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAVSPYIVDFYGAFFVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYAVVQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKTNIGCQSYMAPERIRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPDSFSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDMASWAKGALKEKGEKRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSPNNQPL
------CCCCCCCCC		55.2829996109
3Phosphorylation-----MSSPNNQPLS
-----CCCCCCCCCC		30.2829996109
70PhosphorylationSDNDSKVSSPSREIP
CCCCCCCCCCCCCCC		40.0229996109
71PhosphorylationDNDSKVSSPSREIPS
CCCCCCCCCCCCCCC		29.8629996109
73PhosphorylationDSKVSSPSREIPSDP
CCCCCCCCCCCCCCC		44.4829996109
78PhosphorylationSPSREIPSDPPLPRA
CCCCCCCCCCCCCCC		69.3029996109
117PhosphorylationPSEKPRRSLPTAAGQ
CCCCCCCCCCCCCCC		39.7221712547
120PhosphorylationKPRRSLPTAAGQNNI
CCCCCCCCCCCCCCC		34.1421712547
129PhosphorylationAGQNNIGSPPTPPGP
CCCCCCCCCCCCCCC		24.7428889911
132PhosphorylationNNIGSPPTPPGPFPG
CCCCCCCCCCCCCCC		45.5624763107
159PhosphorylationFHASRSKSMPEVVNK
HHHHCCCCHHHHHHH		40.5928889911
168PhosphorylationPEVVNKISSPTTPIV
HHHHHHCCCCCCCCC		31.6928889911
169PhosphorylationEVVNKISSPTTPIVG
HHHHHCCCCCCCCCC		29.7321712547
171PhosphorylationVNKISSPTTPIVGMG
HHHCCCCCCCCCCCC		47.3429996109
195PhosphorylationSQLAGRLSNSPVKSP
HHHCHHHCCCCCCCC		33.6225720772
197PhosphorylationLAGRLSNSPVKSPNM
HCHHHCCCCCCCCCC		27.9129996109
201PhosphorylationLSNSPVKSPNMPESG
HCCCCCCCCCCCCCH		23.0325720772
207PhosphorylationKSPNMPESGLAKSLA
CCCCCCCCHHHHHHH		32.9829996109
225PhosphorylationNPLLNRPTSFNRQTR
CCHHCCCCCCCCCCC		42.5925720772
226PhosphorylationPLLNRPTSFNRQTRI
CHHCCCCCCCCCCCC		24.1725720772
244PhosphorylationPPGKLDLSNSNPTSP
CCCCCCCCCCCCCCC		37.5725720772
246PhosphorylationGKLDLSNSNPTSPVS
CCCCCCCCCCCCCCC		40.5921712547
249PhosphorylationDLSNSNPTSPVSPSS
CCCCCCCCCCCCHHH		50.3321712547
250PhosphorylationLSNSNPTSPVSPSSM
CCCCCCCCCCCHHHH		25.2621712547
253PhosphorylationSNPTSPVSPSSMASR
CCCCCCCCHHHHHHH		23.5828889911
255PhosphorylationPTSPVSPSSMASRRG
CCCCCCHHHHHHHCC		25.8229996109
469PhosphorylationVSGNLVASISKTNIG
CCCCEEEEEECCCCC		21.66-
473PhosphorylationLVASISKTNIGCQSY
EEEEEECCCCCCCCC		25.85-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
469SPhosphorylationKinaseWIS4O14299
GPS
473TPhosphorylationKinaseWIS4O14299
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WIS1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WIS1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC37_SCHPOcdc37genetic
12861001
GPD2_SCHPOgpd2genetic
7498541
GPD1_SCHPOgpd1genetic
7498541
HOG1_SCHPOsty1physical
12181336
WIS1_SCHPOwis1physical
9718372
HOG1_SCHPOsty1physical
9718372
HOG1_SCHPOsty1physical
10398679
MCS4_SCHPOmcs4genetic
9136929
WEE1_SCHPOwee1genetic
1756736
CDK1_SCHPOcdc2genetic
1756736
MPIP_SCHPOcdc25genetic
1756736
PP2A2_SCHPOppa2genetic
1756736
KCC2_SCHPOcmk2genetic
11886858
WIS4_SCHPOwis4genetic
9450957
HOG1_SCHPOsty1genetic
9450957
WIN1_SCHPOwin1genetic
9450957
GTI1_SCHPOgti1genetic
9372449
PP2C4_SCHPOptc4genetic
22139357
CTK1_SCHPOlsk1genetic
22144909
ATF1_SCHPOatf1genetic
15870269
PP2A1_SCHPOppa1genetic
1756736
SRK1_SCHPOsrk1genetic
12080074
WIN1_SCHPOwin1genetic
9321395
WIS4_SCHPOwis4genetic
9321395
HOG1_SCHPOsty1physical
7501024
HOG1_SCHPOsty1genetic
7501024
ATF1_SCHPOatf1genetic
8824587
MPR1_SCHPOmpr1physical
23695164
HOG1_SCHPOsty1genetic
8557102
SDS23_SCHPOsds23genetic
23640764
MPR1_SCHPOmpr1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WIS1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-253, ANDMASS SPECTROMETRY.

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