KCC2_SCHPO - dbPTM
KCC2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCC2_SCHPO
UniProt AC O42844
Protein Name Calcium/calmodulin-dependent protein kinase type II
Gene Name cmk2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 504
Subcellular Localization Cytoplasm .
Protein Description Has a role in the regulation of G2/M transition during mitosis..
Protein Sequence MSILAGFKNLLKHSKSSKGRSNASKSVDVSVNRDVAAYTELAAKNVNAGGDEEIRVANYPGLEKYQLIENLGDGAFSQVYKAYSIDRKEHVAVKVIRKYEMNKKQRQGVFKEVNIMRRVKHKNVVNLFDFVETEDFYHLVMELAEGGELFHQIVNFTYFSENLARHIIIQVAEAVKHLHDVCGIVHRDIKPENLLFQPIEYLPSQNYTPPSLEPNKLDEGMFLEGIGAGGIGRILIADFGFSKVVWNSKTATPCGTVGYAAPEIVNDELYSKNVDMWAMGCVLHTMLCGFPPFFDENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPRERYDIHQFFQHPWIKGESKMPENFTYKPKLHGTPGGPKLSLPRSLVSKGEIDIPTTPIKSATHPLLSSYSEPKTPGVSSVHEAMGVAYDIRRLNHLGFSPEQLSKKSMNTGSIKELILDEETTTDDDDYIISSFPLNDTLGSEGKDPFSLNLKESSLYSRRSAKRVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
250PhosphorylationKVVWNSKTATPCGTV
EEEEECCCCCCCCCC		35.2725720772
252PhosphorylationVWNSKTATPCGTVGY
EEECCCCCCCCCCCC		25.0928889911
256PhosphorylationKTATPCGTVGYAAPE
CCCCCCCCCCCCCCH		19.9225720772
259PhosphorylationTPCGTVGYAAPEIVN
CCCCCCCCCCCHHHC		8.6829996109
381PhosphorylationPKLSLPRSLVSKGEI
CCCCCCHHHHCCCCC		31.0525720772
392PhosphorylationKGEIDIPTTPIKSAT
CCCCCCCCCCCCCCC		45.6024763107
393PhosphorylationGEIDIPTTPIKSATH
CCCCCCCCCCCCCCC		20.0528889911
404PhosphorylationSATHPLLSSYSEPKT
CCCCCHHHCCCCCCC		34.6124763107
405PhosphorylationATHPLLSSYSEPKTP
CCCCHHHCCCCCCCC		32.4229996109
415PhosphorylationEPKTPGVSSVHEAMG
CCCCCCCCHHHHHHC		32.3421712547
436PhosphorylationRLNHLGFSPEQLSKK
HHHHCCCCHHHHCCC		26.2328889911
449PhosphorylationKKSMNTGSIKELILD
CCCCCCCCCCEEEEC		28.5727738172
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCC2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCC2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCC2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOG1_SCHPOsty1physical
11886858
HOG1_SCHPOsty1physical
12589433
HOG1_SCHPOsty1physical
15870269
SVF1_SCHPOSPCC584.11cgenetic
22681890
RAF2_SCHPOraf2genetic
22681890
LUB1_SCHPOlub1genetic
22681890
CTBL1_SCHPOSPAC1952.06cgenetic
22681890
CLR4_SCHPOclr4genetic
22681890
ROK1_SCHPOrok1genetic
22681890
GMA12_SCHPOgma12genetic
22681890
RL16B_SCHPOrpl1601genetic
22681890
TOM70_SCHPOtom70genetic
22681890
FFT3_SCHPOfft3genetic
22681890
IWR1_SCHPOiwr1genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCC2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-252, AND MASSSPECTROMETRY.

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