MCS4_SCHPO - dbPTM
MCS4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCS4_SCHPO
UniProt AC P87323
Protein Name Response regulator mcs4
Gene Name mcs4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 522
Subcellular Localization Cytoplasm .
Protein Description Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle..
Protein Sequence MRIWFKKVPDGITSSVILSEDHLVDDLKDAIARKFPIRISQYYDAPELSIRVVAPPNASSELQSRELSPNESILFVMETYYPHGQDFNDALLVASPDTSVALRYRSSQLSSSTFESTPPVFSEYPPNIIPTPANETVPRIKQPSIALDSLESPVSAPSRHQSTYSYKGGPLNYNLRNASRTRSHQTLPSSNVNKTGVLLLPRSSRQQTLASRPSLPDLTSADKSQPSDEAESITRKNSIGMSTRSDESTAEKLAKAEVATPTNSRSISHSSLYTKQSGTAGVLPAVNADIDAANRMNPDISSQFPIADNKDPLNADTQAHLGFPSNQIDGIVGTSPVNVLTSPGIGAKAPFASLLEGVIPPINVLIVEDNIINQKILETFMKKRNISSEVAKDGLEALEKWKKKSFHLILMDIQLPTMSGIEVTQEIRRLERLNAIGVGAPKLTQPIPEKDQLNENKFQSPVIIVALTASSLMADRNEALAAGCNDFLTKPVSLVWLEKKITEWGCMQALIDWNGWCRFRGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
131PhosphorylationYPPNIIPTPANETVP
CCCCCCCCCCCCCCC		25.3227738172
144PhosphorylationVPRIKQPSIALDSLE
CCCCCCCCEEHHCCC		20.2829996109
149PhosphorylationQPSIALDSLESPVSA
CCCEEHHCCCCCCCC		34.5829996109
152PhosphorylationIALDSLESPVSAPSR
EEHHCCCCCCCCCCC		35.5825720772
155PhosphorylationDSLESPVSAPSRHQS
HCCCCCCCCCCCCCC		37.5321712547
183PhosphorylationRNASRTRSHQTLPSS
CCCCCCCCCCCCCCC		21.2329996109
186PhosphorylationSRTRSHQTLPSSNVN
CCCCCCCCCCCCCCC		34.9029996109
208PhosphorylationPRSSRQQTLASRPSL
ECCHHHCHHHCCCCC		18.8929996109
211PhosphorylationSRQQTLASRPSLPDL
HHHCHHHCCCCCCCC		48.0829996109
214PhosphorylationQTLASRPSLPDLTSA
CHHHCCCCCCCCCCC		51.9628889911
219PhosphorylationRPSLPDLTSADKSQP
CCCCCCCCCCCCCCC		29.2829996109
224PhosphorylationDLTSADKSQPSDEAE
CCCCCCCCCCCHHHH		48.1229996109
232PhosphorylationQPSDEAESITRKNSI
CCCHHHHHHHHCCCC		35.9929996109
234PhosphorylationSDEAESITRKNSIGM
CHHHHHHHHCCCCCC		44.8929996109
238PhosphorylationESITRKNSIGMSTRS
HHHHHCCCCCCCCCC		24.4528889911
242PhosphorylationRKNSIGMSTRSDEST
HCCCCCCCCCCCHHH		18.5621712547
243PhosphorylationKNSIGMSTRSDESTA
CCCCCCCCCCCHHHH		25.8721712547
245PhosphorylationSIGMSTRSDESTAEK
CCCCCCCCCHHHHHH		45.9024763107
248PhosphorylationMSTRSDESTAEKLAK
CCCCCCHHHHHHHHH		37.6025720772
249PhosphorylationSTRSDESTAEKLAKA
CCCCCHHHHHHHHHC		36.4725720772
260PhosphorylationLAKAEVATPTNSRSI
HHHCCCCCCCCCCCC		35.5021712547
262PhosphorylationKAEVATPTNSRSISH
HCCCCCCCCCCCCCC		41.2821712547
264PhosphorylationEVATPTNSRSISHSS
CCCCCCCCCCCCCCC		29.8629996109
266PhosphorylationATPTNSRSISHSSLY
CCCCCCCCCCCCCEE		28.4121712547
268PhosphorylationPTNSRSISHSSLYTK
CCCCCCCCCCCEEEC		20.6825720772
270PhosphorylationNSRSISHSSLYTKQS
CCCCCCCCCEEECCC		18.4321712547
271PhosphorylationSRSISHSSLYTKQSG
CCCCCCCCEEECCCC		21.7025720772
273PhosphorylationSISHSSLYTKQSGTA
CCCCCCEEECCCCCC		17.5329996109
334PhosphorylationQIDGIVGTSPVNVLT
HCCCEECCCCCEEEC		20.9729996109
335PhosphorylationIDGIVGTSPVNVLTS
CCCEECCCCCEEECC		22.4121712547
341PhosphorylationTSPVNVLTSPGIGAK
CCCCEEECCCCCCCC		28.7029996109
342PhosphorylationSPVNVLTSPGIGAKA
CCCEEECCCCCCCCC		19.5721712547
412PhosphorylationSFHLILMDIQLPTMS
CCEEEEEECCCCCCC		23.26-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MCS4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCS4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCS4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPR1_SCHPOmpr1physical
10940030
WIS4_SCHPOwis4physical
11179424
BQT4_SCHPObqt4genetic
18931302
RAD3_SCHPOrad3genetic
18931302
GYP1_SCHPOgyp1genetic
18931302
NSE5_SCHPOnse5genetic
18931302
PLMT_SCHPOcho1genetic
18931302
NSE6_SCHPOnse6genetic
18931302
VPS8_SCHPOvps8genetic
18931302
RYH1_SCHPOryh1genetic
18931302
MPIP_SCHPOcdc25genetic
9136929
WIS4_SCHPOwis4genetic
9136929
WIS1_SCHPOwis1genetic
9136929
HOG1_SCHPOsty1genetic
9136929
MPIP_SCHPOcdc25genetic
9383051
MPR1_SCHPOmpr1physical
20946853
MCS4_SCHPOmcs4physical
23695164
MCS4_SCHPOmcs4physical
26771498
PSB3_SCHPOpup3physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MCS4_SCHPO

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Related Literatures of Post-Translational Modification

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