RAD3_SCHPO - dbPTM
RAD3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD3_SCHPO
UniProt AC Q02099
Protein Name Protein kinase rad3
Gene Name rad3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 2386
Subcellular Localization Nucleus.
Protein Description Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. [PubMed: 8978690]
Protein Sequence MSQHAKRKAGSLDLSPRGLDDRQAFGQLLKEVLALDKEHELGRSNSLPSMTSELVEVLIEVGLLAFKHDDSKSEFISPKMLKEAHLSLQALMLILKRSPTVLREIKSSVTLLDWILPRTISLFADIRFIKLFDSLKEFHKLIYQLISEKSFLWDLYASFMRYWKYYITNVSSIVLQITNATFPYKMPSPNSQPLQSITPNYPTHREDKFDLLIINIEEACTFFFESAHFFAQCSYLKKSNFPSPPLFTAWTWIKPCFFNFVILLKRISIGDSQLFLHLHSRIVQTLCCFSLNFIYHGLPICEKSKHILMSSINLTLGSLKKTYTVANTAISLFFLSLFVLPKTVAGLFYPFGVSLLSDFKVLEQLEPDSDLKKAIILFKCRYQSSEIDQTTLRAFGEICTGKLENTLFSNSELNLFLLHYLSLDNDLSNILKVDFQNGHNICTFAKWCINNNLDEPSNLKHFREMLDYYSSHNVTISEDDLKNFSLVLCTHVAKVNEKTNSIFRTYEVHGCEVCNSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKSVKMSLKDHFRLSFDDPVDLVIPAKSFLDITLPAKDANRASHYPFPKTQPTLLKFEDEVDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDLRKDARLMEFNNLICKILRKDQEANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPISYQEIKVDLDFALRSPNPGDIFEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASEITMRLLRSNQDTLMSVLESFLHDPLVEWNRKKSSSKYPNNEANEVLDIIRKKFQGFMPGETIPLSIEGQIQELIKSAVNPKNLVEMYIGWAAYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationHAKRKAGSLDLSPRG
HHHHHHCCCCCCCCC		24.4625720772
15PhosphorylationKAGSLDLSPRGLDDR
HHCCCCCCCCCCCHH		16.5325720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD26_SCHPOrad26physical
10559981
CHK1_SCHPOchk1genetic
9857181
CHK1_SCHPOchk1physical
9857181
CDS1_SCHPOcds1physical
9857181
CDS1_SCHPOcds1genetic
9857181
CID13_SCHPOcid13genetic
12062100
UVE1_SCHPOuve1genetic
10480889
RAD4_SCHPOrad4genetic
12865439
TAZ1_SCHPOtaz1genetic
12196391
ATM_SCHPOtel1genetic
15226425
SRW1_SCHPOsrw1genetic
9398669
SLP1_SCHPOslp1genetic
15347659
MAD2_SCHPOmad2genetic
15347659
CDS1_SCHPOcds1physical
11313465
CDS1_SCHPOcds1physical
10825192
RAD3_SCHPOrad3physical
10512862
CHK1_SCHPOchk1physical
10512862
RHP9_SCHPOcrb2physical
14739927
CHK1_SCHPOchk1physical
11553781
RAD26_SCHPOrad26physical
15229228
NRM1_SCHPOnrm1genetic
18682565
CDC10_SCHPOcdc10genetic
18662996
CSN1_SCHPOcsn1genetic
18931302
NSE6_SCHPOnse6genetic
18931302
PLI1_SCHPOpli1genetic
18931302
RAD57_SCHPOrad57genetic
18931302
DDB1_SCHPOddb1genetic
18931302
RHP41_SCHPOrhp41genetic
18931302
FEN1_SCHPOrad2genetic
18931302
TLG2_SCHPOtlg2genetic
18931302
SRS2_SCHPOsrs2genetic
18931302
POB3_SCHPOpob3genetic
19547744
PLI1_SCHPOpli1genetic
19547744
CDC10_SCHPOcdc10genetic
19750219
ATM_SCHPOtel1genetic
16618806
HUS2_SCHPOrqh1genetic
17893680
RAD26_SCHPOrad26physical
20140190
MAD2_SCHPOmad2genetic
20375067
RAD26_SCHPOrad26genetic
20505337
ATM_SCHPOtel1genetic
20505337
TERT_SCHPOtrt1genetic
20505337
RAD1_SCHPOrad1genetic
20505337
RAD17_SCHPOrad17genetic
20505337
CTF18_SCHPOctf18genetic
20505337
RFA3_SCHPOssb3genetic
20885790
COM1_SCHPOctp1genetic
21098122
NBS1_SCHPOnbs1genetic
21098122
CHK1_SCHPOchk1genetic
21098122
CDS1_SCHPOcds1genetic
21098122
ATM_SCHPOtel1genetic
21098122
RHP9_SCHPOcrb2genetic
21098122
HUS1_SCHPOhus1genetic
21098122
H2A2_SCHPOhta2genetic
21098122
MEK1_SCHPOmek1physical
21084840
MRC1_SCHPOmrc1physical
21099360
RAD3_SCHPOrad3genetic
21123655
YOX1_SCHPOyox1genetic
21304269
YK82_SCHPObdf2genetic
22095079
CCQ1_SCHPOccq1physical
22302936
CG23_SCHPOcdc13physical
22761595
CID1_SCHPOcid1genetic
10757807
RAD13_SCHPOrad13genetic
10480889
SPM1_SCHPOpmk1genetic
22918952
CDK1_SCHPOcdc2genetic
22918952
ATM_SCHPOtel1genetic
23080121
RAD32_SCHPOmre11genetic
23080121
DDB1_SCHPOddb1genetic
22681890
YEC6_SCHPOpcf3genetic
22681890
NSE6_SCHPOnse6genetic
22681890
YOI5_SCHPOSPBC1778.05cgenetic
22681890
FEN1_SCHPOrad2genetic
22681890
YEG3_SCHPOpcf2genetic
22681890
RFA3_SCHPOssb3genetic
22681890
RT109_SCHPOrtt109genetic
22681890
YEN1_SCHPOSPAC11G7.01genetic
22681890
RAD55_SCHPOrad55genetic
22681890
PLI1_SCHPOpli1genetic
22681890
CCQ1_SCHPOccq1genetic
22681890
DCC1_SCHPOdcc1genetic
22681890
HRQ1_SCHPOhrq1genetic
22681890
MBO1_SCHPOmto1genetic
22681890
EXO1_SCHPOexo1genetic
22681890
DCTD_SCHPOdcd1genetic
22681890
CSN1_SCHPOcsn1genetic
22681890
NTH_SCHPOnth1genetic
22681890
ARP42_SCHPOarp42genetic
22681890
RAD57_SCHPOrad57genetic
22681890
YIDH_SCHPOSPAC227.17cgenetic
22681890
MCL1_SCHPOmcl1genetic
22681890
RHP23_SCHPOrhp23genetic
22681890
TOR1_SCHPOtor1genetic
19546237
WEE1_SCHPOwee1genetic
9398669
SRW1_SCHPOsrw1genetic
14985109
TOP1_SCHPOtop1genetic
23703609
RAD50_SCHPOrad50genetic
24493214
ATM_SCHPOtel1genetic
24493214
RAD26_SCHPOrad26physical
24663817
CDS1_SCHPOcds1physical
24663817
EXO1_SCHPOexo1genetic
24623809
SPD1_SCHPOspd1genetic
24623809
SPD1_SCHPOspd1genetic
26918805
MPIP_SCHPOcdc25genetic
26918805
ATM_SCHPOtel1genetic
26746798
RIR2_SCHPOsuc22genetic
26746798
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD3_SCHPO

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Related Literatures of Post-Translational Modification

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