HUS2_SCHPO - dbPTM
HUS2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HUS2_SCHPO
UniProt AC Q09811
Protein Name ATP-dependent DNA helicase hus2/rqh1
Gene Name rqh1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1328
Subcellular Localization Nucleus .
Protein Description Has a role in the repair of UV-induced DNA damage in G2 via recombination-mediated repair. Also has a role in the repair of infrared-induced double DNA strand breaks. Exhibits an ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction..
Protein Sequence MTVTKTNLNRHLDWFFRESPQKIENVTSPIKTLDFVKVKVSSSDIVVKDSIPHKSKNVFDDFDDGYAIDLTEEHQSSSLNNLKWKDVEGPNILKPIKKIAVPASESEEDFDDVDEEMLRAAEMEVFQSCQPLAVNTADTTVSHSTSSSNVPRSLNKIHDPSRFIKDNDVENRIHVSSASKVASISNTSKPNPIVSENPISATSVSIEIPIKPKELSNNLPFPRLNNNNTNNNNDNNAIEKRDSASPTPSSVSSQISIDFSTWPHQNLLQYLDILRDEKSEISDRIIEVMERYPFSSRFKEWIPKRDILSQKISSVLEVLSNNNNSNNNNGNNGTVPNAKTFFTPPSSITQQVPFPSTIIPESTVKENSTRPYVNSHLVANDKITATPFHSEAVVSPLQSNIRNSDIAEFDEFDIDDADFTFNTTDPINDESGASSDVVVIDDEEDDIENRPLNQALKASKAAVSNASLLQSSSLDRPLLGEMKDKNHKVLMPSLDDPMLSYPWSKEVLGCLKHKFHLKGFRKNQLEAINGTLSGKDVFILMPTGGGKSLCYQLPAVIEGGASRGVTLVISPLLSLMQDQLDHLRKLNIPSLPLSGEQPADERRQVISFLMAKNVLVKLLYVTPEGLASNGAITRVLKSLYERKLLARIVIDEAHCVSHWGHDFRPDYKQLGLLRDRYQGIPFMALTATANEIVKKDIINTLRMENCLELKSSFNRPNLFYEIKPKKDLYTELYRFISNGHLHESGIIYCLSRTSCEQVAAKLRNDYGLKAWHYHAGLEKVERQRIQNEWQSGSYKIIVATIAFGMGVDKGDVRFVIHHSFPKSLEGYYQETGRAGRDGKPAHCIMFYSYKDHVTFQKLIMSGDGDAETKERQRQMLRQVIQFCENKTDCRRKQVLAYFGENFDKVHCRKGCDICCEEATYIKQDMTEFSLQAIKLLKSISGKATLLQLMDIFRGSKSAKIVENGWDRLEGAGVGKLLNRGDSERLFHHLVSEGVFVEKVEANRRGFVSAYVVPGRQTIINSVLAGKRRIILDVKESSSKPDTSSRSLSRSKTLPALREYQLKSTTASVDCSIGTREVDEIYDSQMPPVKPSLIHSRNKIDLEELSGQKFMSEYEIDVMTRCLKDLKLLRSNLMAIDDSRVSSYFTDSVLLSMAKKLPRNVKELKEIHGVSNEKAVNLGPKFLQVIQKFIDEKEQNLEGTELDPSLQSLDTDYPIDTNALSLDHEQGFSDDSDSVYEPSSPIEEGDEEVDGQRKDILNFMNSQSLTQTGSVPKRKSTSYTRPSKSYRHKRGSTSYSRKRKYSTSQKDSRKTSKSANTSFIHPMVKQNYR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
104PhosphorylationKKIAVPASESEEDFD
EEEEECCCCCCCCCC		35.2725720772
106PhosphorylationIAVPASESEEDFDDV
EEECCCCCCCCCCCC		43.7325720772
395PhosphorylationFHSEAVVSPLQSNIR
CCCHHHCCCHHHCCC		17.1929996109
1138PhosphorylationNLMAIDDSRVSSYFT
CCCCCCCHHHHHHHH		30.7325720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HUS2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HUS2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HUS2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD60_SCHPOrad60genetic
16880212
MUS81_SCHPOmus81genetic
16710300
SLX1_SCHPOslx1genetic
16710300
SLX4_SCHPOslx4genetic
16710300
SWI3_SCHPOswi3genetic
16710300
SWI1_SCHPOswi1genetic
16710300
SRS2_SCHPOsrs2genetic
16710300
TOP3_SCHPOtop3genetic
10572171
RAD13_SCHPOrad13genetic
9372918
UVE1_SCHPOuve1genetic
9372918
TOP1_SCHPOtop1genetic
12084712
CHK1_SCHPOchk1genetic
15226425
TOP3_SCHPOtop3genetic
15702347
RAD54_SCHPOrad54genetic
15802523
RAD55_SCHPOrad55genetic
15802523
RAD60_SCHPOrad60genetic
16354704
RAD57_SCHPOrad57genetic
16354704
MAD2_SCHPOmad2genetic
16303848
REB1_SCHPOreb1genetic
16303848
RAD57_SCHPOrad57genetic
16135799
CUT8_SCHPOcut8genetic
17178839
RAD3_SCHPOrad3genetic
17178839
TOP3_SCHPOtop3physical
15702347
TOP3_SCHPOtop3physical
12724426
TOP1_SCHPOtop1physical
15702347
RAD13_SCHPOrad13genetic
7623848
RFA1_SCHPOssb1physical
17429064
RAD9_SCHPOrad9genetic
9566891
H2A1_SCHPOhta1genetic
15226425
H2A2_SCHPOhta2genetic
15226425
RAD55_SCHPOrad55genetic
14993467
RAD57_SCHPOrad57genetic
14993467
RAD55_SCHPOrad55genetic
16135800
BRC1_SCHPObrc1genetic
20661445
H2A1_SCHPOhta1genetic
20661445
H2A2_SCHPOhta2genetic
20661445
SWI5_SCHPOswi5genetic
15802523
CHK1_SCHPOchk1genetic
21098121
SWS1_SCHPOsws1genetic
16710300
RDL1_SCHPOrdl1genetic
16710300
COM1_SCHPOctp1genetic
21931565
RAD32_SCHPOmre11genetic
21931565
TERT_SCHPOtrt1genetic
22313747
RAD13_SCHPOrad13genetic
9092661
CHK1_SCHPOchk1genetic
9372918
SFR1_SCHPOsfr1genetic
18769921
EXO1_SCHPOexo1genetic
23297345
RAD57_SCHPOrad57genetic
23297345
CHK1_SCHPOchk1genetic
23584455
EME1_SCHPOeme1genetic
23584455
RAD57_SCHPOrad57genetic
23828040
SWI5_SCHPOswi5genetic
23828040
BUB1_SCHPObub1genetic
24469396
MAD2_SCHPOmad2genetic
24469396
CHK1_SCHPOchk1genetic
24469396
RLF2_SCHPOpcf1genetic
25313826
SRS2_SCHPOsrs2genetic
25313826
YEG3_SCHPOpcf2genetic
25313826
HUS2_SCHPOrqh1physical
26771498
PRP40_SCHPOusp104physical
26771498
MUG79_SCHPOspo7physical
26771498
ATG11_SCHPOatg11physical
26771498
CBH1_SCHPOcbh1physical
26771498
MCM10_SCHPOcdc23physical
26771498
YBJ2_SCHPOSPBC337.02cphysical
26771498
RFA1_SCHPOssb1physical
26771498
YQO1_SCHPOSPCC569.01cphysical
26771498
YJ51_SCHPOSPCP20C8.01cphysical
26771498
CHK1_SCHPOchk1genetic
26093291
WEE1_SCHPOwee1genetic
26093291
MIK1_SCHPOmik1genetic
26093291
CDK1_SCHPOcdc2genetic
26093291
EXO1_SCHPOexo1genetic
26957021
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HUS2_SCHPO

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Related Literatures of Post-Translational Modification

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