| UniProt ID | BRC1_SCHPO | |
|---|---|---|
| UniProt AC | Q10337 | |
| Protein Name | BRCT-containing protein 1 | |
| Gene Name | brc1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 878 | |
| Subcellular Localization | ||
| Protein Description | Required for mitotic fidelity, specifically in the G2 phase of the cell cycle. Plays a role in chromatin organization.. | |
| Protein Sequence | MEKIKLLNVKTPNHYTIIFKVVAYYSALQPNQNELRKKELFIKNDGKALSFPYDWKLATHVICDDFSSPNVQEGSKRSLRLAKTNWIRDCVDKNTLLNYSFYSCNPYLLFKGICASSCQIDSYQSSLIDDALETFGGRFSKGLMKSMTHLFTYSGMGAKCKKVLDKPSLSIKLIHPQWLLDCLQFGQLIDQDPYLFPNPSYKKNDSSISKAEPTSLFRNVLHGKRIYFSNDLNLPTNFRHSLQKFSVGIGAKIAESINDCDIFIGLKRDTIEFNLASNKNTTIGTISWLLNLFVLGSWKSPLLNALHYPFPSVGFLKDQMVAVTNYTDAARIYLEKLLLACGATYTKDLKPTNTLLIAASSYGQKYGAAKVWNIPTVHHSWLYSSFKNLSSQAFTDFPVPLDDSYMDFIFPCPLNVEKGSFEDTLKSSLTKGNSEVLLDDLSDPSVSSIKGNKTNEELEKEFKSTSDNFGKHIILTSSFSNQSADKGSSLAAEDDRNDEGSTITGVNRELQDEGRLEIDAKSSKTNTPPSPLLVGTPSKESLKEASSDDELPVLATKLVDNVIKEKSPLSLTPKVVVPSHKETYTDEKKLIDELDRVNPLNSSQLLRSKRKSAATALSMLQNVIMPDVLAFEREKKRRQTHRSVSSGEVSRESSESRNTNAKASKRVYITFTGYDKKPSIDNLKKLDMSITSNPSKCTHLIAPRILRTSKFLCSIPYGPCVVTMDWINSCLKTHEIVDEEPYLLNDPEKELELGCTLESALKRARAQGPSLLEDYVVYLTSKTVAPENVPAVISIVKSNGGVCSTLNVYNKRLARHLEDGNVVLITCNEDSHIWTNFLDNASQNKTIFLQNYDWLIKTVLRQEIDVNDRIADEFARAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 434 | Phosphorylation | SSLTKGNSEVLLDDL HHHCCCCCEEEECCC | 37.44 | 25720772 | |
| 442 | Phosphorylation | EVLLDDLSDPSVSSI EEEECCCCCCCHHHH | 55.24 | 24763107 | |
| 445 | Phosphorylation | LDDLSDPSVSSIKGN ECCCCCCCHHHHCCC | 39.35 | 24763107 | |
| 447 | Phosphorylation | DLSDPSVSSIKGNKT CCCCCCHHHHCCCCC | 30.59 | 21712547 | |
| 448 | Phosphorylation | LSDPSVSSIKGNKTN CCCCCHHHHCCCCCH | 26.60 | 24763107 | |
| 541 | Phosphorylation | VGTPSKESLKEASSD CCCCCHHHHHHCCCC | 48.77 | 28889911 | |
| 546 | Phosphorylation | KESLKEASSDDELPV HHHHHHCCCCCCHHH | 35.08 | 24763107 | |
| 547 | Phosphorylation | ESLKEASSDDELPVL HHHHHCCCCCCHHHH | 57.01 | 24763107 | |
| 567 | Phosphorylation | DNVIKEKSPLSLTPK HHHHHCCCCCCCCCC | 31.97 | 28889911 | |
| 570 | Phosphorylation | IKEKSPLSLTPKVVV HHCCCCCCCCCCEEC | 33.31 | 21712547 | |
| 572 | Phosphorylation | EKSPLSLTPKVVVPS CCCCCCCCCCEECCC | 20.07 | 24763107 | |
| 612 | Phosphorylation | LLRSKRKSAATALSM HHHHHHHHHHHHHHH | 27.46 | 21712547 | |
| 650 | Phosphorylation | SVSSGEVSRESSESR CCCCCCCCCCCCCCC | 26.48 | 25720772 | |
| 653 | Phosphorylation | SGEVSRESSESRNTN CCCCCCCCCCCCCCC | 37.99 | 25720772 | |
| 654 | Phosphorylation | GEVSRESSESRNTNA CCCCCCCCCCCCCCC | 34.53 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BRC1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRC1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRC1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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