KU80_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KU80_SCHPO
• UniProt AC: Q9HGM8
• Protein Name: ATP-dependent DNA helicase II subunit 2
• Gene Name: pku80
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 695
• Subcellular Localization: Nucleus. Chromosome, telomere.
• Protein Description: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity)..
• Protein Sequence: MSDKECTVFVLDLGKDMGTCHHGRSHSDLEWTLSYFHDELSHKFLANRKTDVVGIVGYKCDDTKNDLAEQEAYWNISVLYPIQTALFSKLQSVSQTLKPSNTMQGDLISAIVVSFDLMARHCKKNKWKKKMIVLTAARGIIDFSDYIGIAEQLLQHDVFLGVYGVDFDQEDINYSEPLKESQKKENEVRIQEFVESCHGQYCTFQQIYNNIGKPWVRKVRPVAIFRGTFSIGNRDSKDTSISIQVERYPRTRLTKPPTSSAFYENDMSKNYECLNIENSNVENKSMESDAVSTVRSYMVRDPKTNDSFEVKREDLESGYSYGRTIVPISRSDEDVLALDTIPGYEILGFIPKSSLPIYYTISDTNIIVPKDDFESKLNFSAFVQSLEREHRYALARFVSKDKGVPVLLVLMPYVEFKRHYLVDIQLPFAEDVRPYSFSEFEKLSNEEDMRQIDFAVSNYIDNMDLDSSDCGFNPPFEPENTFSMIPHRLQQAISYYANSPEGDLPQPNIYLTRYTNPPKSLLDNCILDLKLIKEKLTVNVPVKPKYSSQETAFDTGAPISEEQIEELLNSGLDEQEGEKLLVLHVSEKDPVGTFTEVLKNPFGLEDALTEMEKVIKNLIDKSKYDLALQSLQSLRLHSILEDEVERFNEYLTRLKKDVMQNNKPKENELINKIRSSGLDIILHDELTRHDNFNNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of KU80_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KU80_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KU80_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KU80_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD22_SCHPO	rad52	genetic	12930956
KU70_SCHPO	pku70	physical	12424244
NSE6_SCHPO	nse6	genetic	18931302
DDB1_SCHPO	ddb1	genetic	18931302
HUS2_SCHPO	rqh1	genetic	19682091
EXO1_SCHPO	exo1	genetic	21931565
SMC2_SCHPO	cut14	physical	23084836
DDB1_SCHPO	ddb1	genetic	22681890
SFT1_SCHPO	sft1	genetic	22681890
NSE6_SCHPO	nse6	genetic	22681890
FEN1_SCHPO	rad2	genetic	22681890
VAM7_SCHPO	SPCC594.06c	genetic	22681890
RAD55_SCHPO	rad55	genetic	22681890
CCQ1_SCHPO	ccq1	genetic	22681890
PPK8_SCHPO	ppk8	genetic	22681890
RAD57_SCHPO	rad57	genetic	22681890
SCS7_SCHPO	scs7	genetic	22681890
YCRA_SCHPO	SPCC285.10c	genetic	22681890
PPK16_SCHPO	ppk16	genetic	22681890
YI43_SCHPO	SPBC1348.03	genetic	22681890
EXO1_SCHPO	exo1	genetic	21441914
HUS2_SCHPO	rqh1	genetic	25965521
EXO1_SCHPO	exo1	genetic	25965521
MUS81_SCHPO	mus81	genetic	25965521
EXO1_SCHPO	exo1	genetic	25580577

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.