| UniProt ID | MUS81_SCHPO | |
|---|---|---|
| UniProt AC | P87231 | |
| Protein Name | Crossover junction endonuclease mus81 | |
| Gene Name | mus81 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 608 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).. | |
| Protein Sequence | MDCGNPLFLQWIQEWMEESTRRFPKSYQTWRKAYDSMKSCPITFHRPSQALALKGIGPTICAKLEKKWNAYCLENNIPISTHNEQNDSHVNANKSSSETSSEKPRSVKKPTTRKRKVYVPSYRSGAYSILCALYMLNKHEFATKPQIVTMAQPYCDSSFGSATDRNMRYTAWSAMKTLITKNLVYQTGHPSKYCLTDDGEEVCIRLAKVDDSFQRKHTVSNFSVSKSDDHDSSLCQPPNFVTSINKAGSSSDHGGELHVTYCPVDHNEVSDGVETDIDVDQVDSLTGIHDHHIINNEQLIDLTEQEKKQPNESNLSNLKIETVLFSNCTVFLLIDTREIRSPLDRNLIIDKLTNDFGVNCQVRSLELGDALWVARDMESGQEVVLDFVVERKRYDDLVASIKDGRFHEQKARLKKSGIRSVTYILEESSYDESFTESIRTAVSNTQVDQLFHVRHTRSLEHSVSLLAEMTKQINLFYEKRKTLAVIPDLSIEAKTYESLREQLLKIDPSTPYHISYHAFSSVLSKSSTLTVGDIFIRMLMTIKGISASKAIEIQKKYPTFMHLFEAYEKSSSSQERNLLLNKTCQGYGFQTIGPALSAKVASVFFPES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of MUS81_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MUS81_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MUS81_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MUS81_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CDS1_SCHPO | cds1 | physical | 15805465 | |
| RAD54_SCHPO | rad54 | genetic | 14993467 | |
| EME1_SCHPO | eme1 | genetic | 12084712 | |
| TOP1_SCHPO | top1 | genetic | 12084712 | |
| HUS2_SCHPO | rqh1 | genetic | 12084712 | |
| RAD13_SCHPO | rad13 | genetic | 11073977 | |
| UVE1_SCHPO | uve1 | genetic | 11073977 | |
| RAD22_SCHPO | rad52 | genetic | 15486206 | |
| EME1_SCHPO | eme1 | physical | 11719193 | |
| CDS1_SCHPO | cds1 | physical | 11073977 | |
| SWI10_SCHPO | swi10 | genetic | 18388861 | |
| TOP1_SCHPO | top1 | genetic | 17307401 | |
| SWI1_SCHPO | swi1 | genetic | 21183410 | |
| MPH1_SCHPO | fml1 | genetic | 22723423 | |
| SFR1_SCHPO | sfr1 | genetic | 22723423 | |
| SPO11_SCHPO | rec12 | genetic | 22723423 | |
| SPO11_SCHPO | rec12 | genetic | 22855558 | |
| SPO11_SCHPO | rec12 | genetic | 24312672 | |
| HOG1_SCHPO | sty1 | genetic | 24748152 | |
| TOP1_SCHPO | top1 | genetic | 21444718 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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