CDS1_SCHPO - dbPTM
CDS1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDS1_SCHPO
UniProt AC Q09170
Protein Name Serine/threonine-protein kinase cds1
Gene Name cds1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 460
Subcellular Localization
Protein Description Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2..
Protein Sequence MEEPEEATQATQEAPLHVSQNIAKQVVNNENVFMKLVMTRMLDGKTEVIPLTTDVHNGFWRFGRHKSCEVVLNGPRVSNFHFEIYQGHRNDSDESENVVFLHDHSSNGTFLNFERLAKNSRTILSNGDEIRIGLGVPKDEISFLCQVPVKHSRDSQKNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKRISESEALQHPWFYTVSTHEHRTPPSSSEHEATEQLNSSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationQEAPLHVSQNIAKQV
HHCCCCCCHHHHHHH		13.5328889911
443PhosphorylationVSTHEHRTPPSSSEH
EECCCCCCCCCCCHH		41.2728889911
458PhosphorylationEATEQLNSSS-----
HHHHHHHCCC-----		40.3225720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDS1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDS1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDS1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD3_SCHPOrad3physical
9857181
RAD4_SCHPOrad4genetic
16723501
CHK1_SCHPOchk1genetic
12808110
CID13_SCHPOcid13genetic
12062100
KU70_SCHPOpku70genetic
12196391
TAZ1_SCHPOtaz1genetic
12196391
CHK1_SCHPOchk1genetic
9774107
CHK1_SCHPOchk1genetic
12081644
RAD24_SCHPOrad24genetic
9832516
CHK1_SCHPOchk1genetic
9832516
H2A1_SCHPOhta1genetic
15226425
H2A2_SCHPOhta2genetic
15226425
CHK1_SCHPOchk1genetic
15155581
SET9_SCHPOset9genetic
15550243
SWI3_SCHPOswi3genetic
15767681
CHK1_SCHPOchk1genetic
15367656
MAD2_SCHPOmad2genetic
15347659
CHK1_SCHPOchk1genetic
17151242
RAD60_SCHPOrad60physical
16880212
MRC1_SCHPOmrc1physical
16618806
CDS1_SCHPOcds1physical
16618806
MRC1_SCHPOmrc1physical
11715017
MRC1_SCHPOmrc1physical
15173168
RAD60_SCHPOrad60physical
12897162
WEE1_SCHPOwee1physical
9572736
MUS81_SCHPOmus81physical
15805465
MPIP_SCHPOcdc25physical
10198041
MPIP_SCHPOcdc25physical
9774107
MPIP_SCHPOcdc25physical
10523629
NRM1_SCHPOnrm1genetic
18682565
NRM1_SCHPOnrm1physical
18682565
DPOD_SCHPOcdc6genetic
18667534
CDC24_SCHPOcdc24genetic
18667534
DPOD3_SCHPOcdc27genetic
18667534
CDC10_SCHPOcdc10genetic
18662996
DDB1_SCHPOddb1genetic
18931302
SWI3_SCHPOswi3genetic
18931302
RAD60_SCHPOrad60physical
19755492
CHK1_SCHPOchk1genetic
19819763
CHK1_SCHPOchk1genetic
14560029
CHK1_SCHPOchk1genetic
16354704
CHK1_SCHPOchk1genetic
15498101
RFA3_SCHPOssb3genetic
20885790
YOX1_SCHPOyox1genetic
21132016
MUS81_SCHPOmus81physical
21084840
WEE1_SCHPOwee1physical
21099360
YOX1_SCHPOyox1genetic
21359180
NRM1_SCHPOnrm1genetic
21359180
CDC10_SCHPOcdc10genetic
19750219
TEA2_SCHPOtea2physical
21336311
PP2B_SCHPOppb1physical
21336311
YK82_SCHPObdf2genetic
22095079
BDF1_SCHPObdf1genetic
22095079
DNA2_SCHPOdna2physical
22682245
DNA2_SCHPOdna2genetic
22682245
CHK1_SCHPOchk1genetic
16849602
ORC1_SCHPOorc1genetic
16849602
CDC45_SCHPOcdc45genetic
16849602
MCM2_SCHPOmcm2genetic
16849602
MUS81_SCHPOmus81physical
11073977
PPK33_SCHPOppk33genetic
22681890
PPK4_SCHPOire1genetic
22681890
DCTD_SCHPOdcd1genetic
22681890
YCS2_SCHPOSPCC613.02genetic
22681890
MCP2_SCHPOmcp2genetic
22681890
SET9_SCHPOset9genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
WTF6_SCHPOwtf6genetic
22681890
ARB2_SCHPOarb2genetic
22681890
PCNA_SCHPOpcn1genetic
9928931
TEL2_SCHPOtel2genetic
17189249
TOR1_SCHPOtor1genetic
19546237
YFF4_SCHPOmcb1genetic
23322785
CHK1_SCHPOchk1genetic
9870697
DPOA_SCHPOpol1genetic
9891047
DPOD2_SCHPOcdc1genetic
9891047
DPOD_SCHPOcdc6genetic
9891047
DPOD3_SCHPOcdc27genetic
9891047
DNLI1_SCHPOcdc17genetic
9891047
RLF2_SCHPOpcf1genetic
24478943
RAD5_SCHPOrad8genetic
24875629
RGF1_SCHPOrgf1physical
24478458
MUS81_SCHPOmus81physical
26771498
HSK1_SCHPOhsk1genetic
23045396
SWI6_SCHPOswi6genetic
23478021
CHP1_SCHPOchp1genetic
23478021
CLR4_SCHPOclr4genetic
23478021
DCR1_SCHPOdcr1genetic
23478021
RIR2_SCHPOsuc22genetic
26746798
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDS1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-443, AND MASSSPECTROMETRY.

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