DPOA_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOA_SCHPO
• UniProt AC: P28040
• Protein Name: DNA polymerase alpha catalytic subunit
• Gene Name: pol1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1405
• Subcellular Localization: Nucleus .
• Protein Description: Polymerase alpha in a complex with DNA primase is a replicative polymerase..
• Protein Sequence: MRKRNAGIKPSQRFAELRALRQAGKTRASTYESKENEELYDNVSEEEYRKIVRQRLDEDDFVVDDNGAGYVDNGYDEWDQSHYSDEDDENEKGSSGRKRKKSKNVLAEPNQQIGAFFKANAIQPASRIANRKNNEKEDEFMAEILGSIDQDIPERLSTKKGNRSHTTSNAKRRSQKAASSISTTNVVSSDPKKYIPETVPSTPQPASSLPIPSSPPAALETEENVDSQPMELDEPELPVGSDAPIIDVEESIAMKPLMSHDQVDDTASLSKATISQQPLSPMTPLSSELDVSAFSEINSKIKNVDVPASSYSSPISKVSPSDVTEEDGSLFFFWMDYTEMYGSLCLFGKVYDKATKQYVSCFLKVDGIMRSLYFLPRPSSSSVSEDSIAAQTKDVYDEVANLLSKRGVKEWKSRVSKYKYAFELEDVPRTADYLEVIYSYSYPALPTDLTGSSFSHVFGTNTALFEQFVLSRRVMGPCWLKIQQPNFDAVKNASWCRVEIGCSSPQNISVSFEKNEITSKTPPMTVMSLAFRTLINKEQNKQEVVMISARIFENVDIEKGLPANDMPSYSFSLIRPLKQIFPNGFEKLARQHKSSIFCERSEVSLLNNFLNKVRTYDPDVYFGHDFEMCYSVLLSRLKERKIHNWSSIGRLRRSEWPRSFNRSSQQFVEKQIIAGRLMCDLSNDFGRSMIKAQSWSLSEIVLKELDIKRQDINQEKALQSWTDTAHGLLDYLVHCEIDTFFIAAVAFKIQMLQLSKNLTNIAGNSWARTLTGTRAERNEYILLHEFKKNGYIVPDKQQSIRRHAEAFGAEDGLQEESLGKKKDKYKGGLVFEPQKGLYETCILVMDFNSLYPSIIQEYNICFTTVDRSPSNSDSDDQIPDTPSASANQGIFPRLIANLVERRRQIKGLLKDNSATPTQRLQWDIQQQALKLTANSMYGCLGYTKSRFYARPLAVLITYKGREALMNTKELADQMGLQVIYGDTDSVMLNTNVTDKNHALRIGNEFKEKVNERYSKLEIDIDNVYQRMLLHAKKKYAALQLDSQGKPNLDVKGLDMKRREFCTLAKEASKFCLDQILSGELTETVIENIHSYLMDFSEKMRNGKFPANKFIIFNRLGKNPEDYPNGKTMPFVQVALKKKARGENVRVGDVIPFIIAGSDADGHPADRAYSPQEIMNTNSTLVIDYNYYLSHQILPPIERVIAPIEGTNRARLAECLGLDARKYYSHETSESSAFQRYESTLTDDQCFINVSPLLLKCPSCNATSFSLRSVKSLKETLYANTVECDCGYEYSDFTIILQFSSQLRDFINLYYEGILVCDDSSCGNRTRQMSVYGKRCCNKSCRGSVHFEYNDEQLYNQIKFLLKAVQTTTGATRNGIIRCNAINKNISRIMNKNAREFVDMGLIFSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	EELYDNVSEEEYRKI HHHHCCCCHHHHHHH	45.61	24763107
48	Phosphorylation	DNVSEEEYRKIVRQR CCCCHHHHHHHHHHH	22.08	27738172
259	Phosphorylation	IAMKPLMSHDQVDDT HCCCCCCCCCCCCCC	31.43	24763107
310	Phosphorylation	NVDVPASSYSSPISK CCCCCCHHCCCCCCC	31.01	24763107
312	Phosphorylation	DVPASSYSSPISKVS CCCCHHCCCCCCCCC	31.42	24763107
313	Phosphorylation	VPASSYSSPISKVSP CCCHHCCCCCCCCCH	20.30	25720772
601	Phosphorylation	SSIFCERSEVSLLNN CCCCCCHHHHHHHHH	21.76	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPOA_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPOA_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOA_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUS81_SCHPO	mus81	genetic	15805465
EME1_SCHPO	eme1	genetic	15805465
SMC2_SCHPO	cut14	genetic	15507118
MCL1_SCHPO	mcl1	genetic	15915339
SWI6_SCHPO	swi6	physical	11387218
PRI2_SCHPO	spp2	physical	11027257
PRI1_SCHPO	spp1	physical	11027257
DPOD3_SCHPO	cdc27	physical	15579205
RAD17_SCHPO	rad17	genetic	12514100
CDS1_SCHPO	cds1	genetic	12514100
PLI1_SCHPO	pli1	genetic	17209013
MUS81_SCHPO	mus81	genetic	11073977
RHP9_SCHPO	crb2	genetic	9407031
RHP9_SCHPO	crb2	genetic	14739927
CHK1_SCHPO	chk1	genetic	14739927
FEN1_SCHPO	rad2	genetic	9891047
HUS2_SCHPO	rqh1	genetic	9891047
RAD26_SCHPO	rad26	genetic	12514100
DPOZ_SCHPO	rev3	genetic	12514100
POLK_SCHPO	kpa1	genetic	12514100
CHK1_SCHPO	chk1	genetic	25822347
RAD50_SCHPO	rad50	genetic	25822347
HUS2_SCHPO	rqh1	genetic	25822347
CKI3_SCHPO	cki3	genetic	25691662
TIP1_SCHPO	tip1	genetic	25691662
PP2B_SCHPO	ppb1	genetic	25691662

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.