PLI1_SCHPO - dbPTM
PLI1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLI1_SCHPO
UniProt AC O94451
Protein Name E3 SUMO-protein ligase pli1
Gene Name pli1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 727
Subcellular Localization Nucleus .
Protein Description Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats..
Protein Sequence MNQANFLQELPNVLKRLETGLIIPQLKDILRVFGLRLSGTKAELITRIKQLIERIAIENNTTSWEALKKAIDGDVTSAVCILKYNTYQIYSAAAPIAPPSSASGNRSYSRPFAPVVHSRIRFRKSPFYDILEQFNAPFVVPACVGTRNTISFSFHVTPPALSKLLNDPKQYRVYLFSTPSETIGFGNCLMEFPTPQMELRINNQVAHANYRRLKGKPGTTNPADITDLVSKYAGPPGNNVVIYYMNSTKSYSVVVCFVKVYTIENLVDQIKSRKAESKEKIIERIKNDNQDADIIATSTDISLKCPLSFSRISLPVRSVFCKHIQCFDASAFLEMNKQTPSWMCPVCASHIQFSDLIIDGFMQHILESTPSNSETITVDPEGNWKLNTFDEPVESSEDEFVPKEKVIELSDGEGISTMANKSNDQPTRRASTHNSGPPAKRKRESLVIDLTISDDDENVATSTTESPSNATKENSLSRNVQSPNIDTAISNRSTNVRHGHPGFKDYTVENSPASRERSTSESAQSSVHMGYAGEGGLLSGALRAPSQQNNNNSNTQHSINLHTIVPSPYEPPLSVTPSTAITNLSIPESNRTNSSASSKSFTMNDLILPPLHLKNTTQTNNAHEDAQSSNLSQNHSLFYERIPQRPSYRIEKQNKGIYEDENEQSISAMPIPRAHPQLPKNLLSQTAGPLWDEQQDAQVDWNSELQSNNSYHNSGFEGTGNTFQSID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
395PhosphorylationTFDEPVESSEDEFVP
CCCCCCCCCCCCCCC		38.9828889911
396PhosphorylationFDEPVESSEDEFVPK
CCCCCCCCCCCCCCH		35.2528889911
410PhosphorylationKEKVIELSDGEGIST
HHHEEECCCCCCCHH		30.6828889911
416PhosphorylationLSDGEGISTMANKSN
CCCCCCCHHHCCCCC		24.0029996109
482PhosphorylationSLSRNVQSPNIDTAI
HCCCCCCCCCHHHHH		18.6828889911
511PhosphorylationKDYTVENSPASRERS
CCCEECCCCCCCCCC		14.3425720772
518PhosphorylationSPASRERSTSESAQS
CCCCCCCCCCHHHHH		31.3725720772
519PhosphorylationPASRERSTSESAQSS
CCCCCCCCCHHHHHH		42.6125720772
525PhosphorylationSTSESAQSSVHMGYA
CCCHHHHHHHHCCCC		33.7625720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLI1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLI1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLI1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD22_SCHPOrad52physical
18031226
TOP1_SCHPOtop1physical
18031226
SMC6_SCHPOsmc6physical
18031226
HUS2_SCHPOrqh1physical
18031226
TOP3_SCHPOtop3physical
18031226
KU70_SCHPOpku70physical
18031226
NSE6_SCHPOnse6genetic
18931302
DDB1_SCHPOddb1genetic
18818364
DAD2_SCHPOdad2genetic
18818364
RAD57_SCHPOrad57genetic
18818364
HRQ1_SCHPOhrq1genetic
18818364
YEG5_SCHPOmga2genetic
18818364
ELP3_SCHPOelp3genetic
18818364
YKX1_SCHPOmsn5genetic
18818364
SPC34_SCHPOspc34genetic
18818364
RAD26_SCHPOrad26genetic
18818364
MCL1_SCHPOmcl1genetic
18818364
EME1_SCHPOeme1genetic
18818364
MPH1L_SCHPOmph1genetic
18818364
ASH2_SCHPOash2genetic
18818364
ELP5_SCHPOelp5genetic
18818364
ASK1_SCHPOask1genetic
18818364
MUB1_SCHPOSPBC31F10.10cgenetic
18818364
HIR1_SCHPOhip1genetic
18818364
ELP1_SCHPOelp1genetic
18818364
ELP6_SCHPOelp6genetic
18818364
CLR3_SCHPOclr3genetic
18818364
SUM2_SCHPOsum2genetic
18818364
HPC2_SCHPOhip4genetic
18818364
ELP4_SCHPOelp4genetic
18818364
RPA12_SCHPOrpa12genetic
18818364
HRR1_SCHPOhrr1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
MU154_SCHPOmug154genetic
18818364
ELP2_SCHPOelp2genetic
18818364
ALP14_SCHPOalp14genetic
18818364
NGG1_SCHPOngg1genetic
18818364
YO48_SCHPOSPBC36B7.08cgenetic
18818364
URK1_SCHPOSPCC162.11cgenetic
18818364
DDB1_SCHPOddb1genetic
22681890
YAI5_SCHPOSPAC24B11.05genetic
22681890
MPH1L_SCHPOmph1genetic
22681890
NSE6_SCHPOnse6genetic
22681890
NU132_SCHPOnup132genetic
22681890
FEN1_SCHPOrad2genetic
22681890
EIF2A_SCHPOSPBC4B4.04genetic
22681890
ELP6_SCHPOelp6genetic
22681890
YEM8_SCHPOclr5genetic
22681890
RAD55_SCHPOrad55genetic
22681890
YKTB_SCHPOSPAPB1E7.11cgenetic
22681890
RPA12_SCHPOrpa12genetic
22681890
NEM1_SCHPOnem1genetic
22681890
HRQ1_SCHPOhrq1genetic
22681890
MBO1_SCHPOmto1genetic
22681890
YNS7_SCHPOSPBC18H10.07genetic
22681890
ASH2_SCHPOash2genetic
22681890
RAD57_SCHPOrad57genetic
22681890
ZFS1_SCHPOzfs1genetic
22681890
ELP3_SCHPOelp3genetic
22681890
ELP1_SCHPOelp1genetic
22681890
YJ53_SCHPOSPCC4F11.03cgenetic
22681890
GMA12_SCHPOgma12genetic
22681890
EME1_SCHPOeme1genetic
22681890
ASK1_SCHPOask1genetic
22681890
YAM5_SCHPOmso1genetic
22681890
FFT3_SCHPOfft3genetic
22681890
DAD2_SCHPOdad2genetic
22681890
MU154_SCHPOmug154genetic
22681890
KLP6_SCHPOklp6genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
RL7B_SCHPOrpl702genetic
22681890
TOP1_SCHPOtop1genetic
23936535
UFD1_SCHPOufd1physical
24265825
PSO2_SCHPOpso2genetic
24192486
MUS81_SCHPOmus81genetic
21444718
TOP1_SCHPOtop1genetic
21444718
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLI1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395 AND SER-396, ANDMASS SPECTROMETRY.

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