SMC6_SCHPO - dbPTM
SMC6_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SMC6_SCHPO
UniProt AC P53692
Protein Name Structural maintenance of chromosomes protein 6
Gene Name smc6
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1140
Subcellular Localization Nucleus. Chromosome.
Protein Description Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis..
Protein Sequence MTTELTNVSLEEAITEKTSENRRKRDSDVLQTEEVDLSNVKRIRASRNQDNRPERQSRLQRSSSLIEQVRGNEDGENDVLNQTRETNSNFDNRVGVIECIHLVNFMCHDSLKINFGPRINFVIGHNGSGKSAILTGLTICLGAKASNTNRAPNMKSLVKQGKNYARISVTISNRGFEAYQPEIYGKSITIERTIRREGSSEYRLRSFNGTVISTKRDELDNICDHMGLQIDNPMNILTQDTARQFLGNSSPKEKYQLFMKGIQLKQLEENYSLIEQSLINTKNVLGNKKTGVSYLAKKEEEYKLLWEQSRETENLHNLLEQKKGEMVWAQVVEVEKELLLAEKEFQHAEVKLSEAKENLESIVTNQSDIDGKISSKEEVIGRAKGETDTTKSKFEDIVKTFDGYRSEMNDVDIQKRDIQNSINAAKSCLDVYREQLNTERARENNLGGSQIEKRANESNNLQREIADLSEQIVELESKRNDLHSALLEMGGNLTSLLTKKDSIANKISDQSEHLKVLEDVQRDKVSAFGKNMPQLLKLITRETRFQHPPKGPMGKYMTVKEQKWHLIIERILGNVINGFIVRSHHDQLILKELMRQSNCHATVVVGKYDPFDYSSGEPDSQYPTVLKIIKFDDDEVLHTLINHLGIEKMLLIEDRREAEAYMKRGIANVTQCYALDPRNRGYGFRIVSTQRSSGISKVTPWNRPPRIGFSSSTSIEAEKKILDDLKKQYNFASNQLNEAKIEQAKFKRDEQLLVEKIEGIKKRILLKRREVNSLESQELSVLDTEKIQTLERRISETEKELESYAGQLQDAKNEEHRIRDNQRPVIEEIRIYREKIQTETQRLSSLQTELSRLRDEKRNSEVDIERHRQTVESCTNILREKEAKKVQCAQVVADYTAKANTRCERVPVQLSPAELDNEIERLQMQIAEWRNRTGVSVEQAAEDYLNAKEKHDQAKVLVARLTQLLQALEETLRRRNEMWTKFRKLITLRTKELFELYLSQRNFTGKLVIKHQEEFLEPRVYPANRNLATAHNRHEKSKVSVQGLSGGEKSFATICMLLSIWEAMSCPLRCLDEFDVFMDAVNRLVSIKMMVDSAKDSSDKQFIFITPQDMGQIGLDKDVVVFRLSDPVVSSSALPPSTAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationENRRKRDSDVLQTEE
HHHHHCCCCCCCCCC		33.3824763107
62PhosphorylationRQSRLQRSSSLIEQV
HHHHHHHHHHHHHHH		16.0025720772
63PhosphorylationQSRLQRSSSLIEQVR
HHHHHHHHHHHHHHH		31.2129996109
64PhosphorylationSRLQRSSSLIEQVRG
HHHHHHHHHHHHHHC		34.3128889911
404PhosphorylationIVKTFDGYRSEMNDV
HHHHCHHHHHHCCCC		16.8927738172
860PhosphorylationLRDEKRNSEVDIERH
HHHHHHHCCCCHHHH		42.9229996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SMC6_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SMC6_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SMC6_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRC1_SCHPObrc1genetic
10473635
FIN1_SCHPOfin1genetic
10473635
TOP2_SCHPOtop2genetic
10473635
BRC1_SCHPObrc1genetic
15972456
SLX1_SCHPOslx1genetic
15972456
NSE5_SCHPOnse5physical
16478984
NSE6_SCHPOnse6physical
16478984
SMC5_SCHPOsmc5physical
15601840
NSE3_SCHPOnse3physical
15601840
NSE4_SCHPOnse4physical
15601840
NSE2_SCHPOnse2physical
15601840
NSE1_SCHPOnse1physical
15601840
NSE2_SCHPOnse2physical
15601841
BRC1_SCHPObrc1genetic
17277362
APN2_SCHPOapn2genetic
17277362
SWI10_SCHPOswi10genetic
17277362
RHP41_SCHPOrhp41genetic
17277362
RAD14_SCHPOrhp14genetic
17277362
TOP2_SCHPOtop2genetic
20495382
TOP2_SCHPOtop2genetic
19528228
BRC1_SCHPObrc1genetic
19528228
CUT1_SCHPOcut1genetic
19528228
RAD60_SCHPOrad60genetic
20885950
BRC1_SCHPObrc1genetic
22366461
H2AZ_SCHPOpht1genetic
24687850
SWR1_SCHPOswr1genetic
24687850
ARP8_SCHPOarp8genetic
24687850
HST4_SCHPOhst4genetic
24687850
RT109_SCHPOrtt109genetic
24687850
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SMC6_SCHPO

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Related Literatures of Post-Translational Modification

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