SMC5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMC5_SCHPO
• UniProt AC: O13710
• Protein Name: Structural maintenance of chromosomes protein 5
• Gene Name: smc5
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1076
• Subcellular Localization: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Barrier septum . Chromosome .
• Protein Description: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis..
• Protein Sequence: MDGLRPSKRRKSNPLYSDYALGSIVRIKLVNFVTYDYCELFPGPYLNLIIGPNGTGKSTIVSAICIGLGWPPKLLGRAKEAREFIKYGKNTATIEIEMKYRDDETVTITRQISQDKSSSFSINREACATSSITSLMDTFNVQLNNLCHFLPQDRVAEFAQLDPYSRLMETERAIDHEGLLPAHEKLIDLRKREREILQNKNQGQSTLNSLKDRQQALEKEVNIFKEREKIKSYIEMLGLAKMLVIYREKTNVFNQLRADKKKLKKDLKDLVEEFQPILDKGEELRSDLKLKDDTFNDYSSASMELNTSNLRARASFSNFMENEKKLYEKVNTNRTLLRNANLTLNEAQQSVKSLTERQGPRPSDNGVQDLQEKMQEVNAEKLQHENEKLESSHELGSIRTLKAQKLIDLDNIKRELSYYNDATKRKLDFMSSAPGWEDAYQTYQLLKEYESAFEAPAYGPIYMNLKCKEKGFAALIEGFFRTDTFRTFIMSNYNDYLKLMDLITSKTKYTPTIREFSSERKKKIEDFEPPCSREKLQSFGFDGYVIDFLEGPEVVLVALCHMLKIHQIPIAKRELPPASVNALNNFRLANGDPVLKTYLAGSSIHLVFRSAYGDREITRRTDPLPSRSIYFSENVEMDLVKRKEEQLNAQLSQLENLQNEERKLQEKVNEHESLLSRTNDILSTLRKERDEKLIPIHEWQQLQERIEHQTLLLRQREKVPEQFAAEIEKNEDIRKENFEALMNSVLKVKENSIKATNNFEKMLGSRLNVIEAKYKLEKHEMDANQVNARLTEVQDRLKDITDKLASAREDAMSLYGSVVDSLQTQSSDRQTAITELNEEFATSSEVDNKISIEETKLKFMNVNSYVMEQYDARKKEIEELESKMSDFDQSVEELQDEMNSIKEDWVSKLEENVQCISDRFSKGMSGMGYAGEVRLGKSDDYDKWYIDILVQFREEEGLQKLTGQRQSGGERSVSTIMYLLSLQGLAIAPFRIVDEINQGMDPRNERVVHRHIVNSVCDNAVSQYFLVTPKLLPDLTYHRNLKVLCICNGAWLPATFRTSLSTYFEKLKKSALISSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RPSKRRKSNPLYSDY CCCCCCCCCCCCCHH	41.70	25720772
16	Phosphorylation	RRKSNPLYSDYALGS CCCCCCCCCHHHCHH	10.76	25720772
286	Phosphorylation	DKGEELRSDLKLKDD HCCHHHHHCCCCCCC	60.98	28889911
308	Phosphorylation	ASMELNTSNLRARAS HHHHCCCCHHHHHHH	32.56	28889911
397	Phosphorylation	ESSHELGSIRTLKAQ HHHHHHCHHHHHHHH	22.86	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMC5_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMC5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMC5_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSE5_SCHPO	nse5	physical	16478984
NSE6_SCHPO	nse6	physical	16478984
SMC6_SCHPO	smc6	physical	16478984
NSE1_SCHPO	nse1	physical	16478984
NSE2_SCHPO	nse2	physical	16478984
NSE3_SCHPO	nse3	physical	16478984
NSE4_SCHPO	nse4	physical	16478984
NSE1_SCHPO	nse1	physical	12966087
SMC6_SCHPO	smc6	physical	10747036
SMC6_SCHPO	smc6	physical	15331764
NSE4_SCHPO	nse4	physical	15331764
NSE3_SCHPO	nse3	physical	15331764
NSE1_SCHPO	nse1	physical	15331764
NSE2_SCHPO	nse2	physical	15331764
SMC6_SCHPO	smc6	physical	26446992
SMC6_SCHPO	smc6	physical	28134253

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.