RAD60_SCHPO - dbPTM
RAD60_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD60_SCHPO
UniProt AC Q9USX3
Protein Name DNA repair protein rad60
Gene Name rad60
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 406
Subcellular Localization Nucleus .
Protein Description Required for repair of DNA double strand breaks which occur during replication, or induced by UV or gamma radiation, via recombination between sister chromatids. This has a subsequent role in the maintenance of chromosome structure. May work in conjunction with the Smc5-Smc6 complex..
Protein Sequence MDNLDEDDLAFFSKPIKKPPLNYAKQLIASSSDSEEESELDTNKQALEHINAQKNITHNENKSAEPLSRQSTILDADEGNQDVSDTTPNACLNEGRHSPKSAISCVTQPVSPVYNTRAAANLRNNSINSEAALSTTSSLLDDDFARRLEEIDRQVQEFEKSSSDMDVQIHTHKREIEEDDDNTSADVPLLKHSKSDHSTLYHSKSEFSTNEPVISVVLQLAVIGQRIPNSNISLPRDWEAPLFFKVKSNQQFRRVRIAYSERKKVDNVVLVFQNQRLWDYGTPKGAGMLKVDTRLVVHAYCHSDFISLKRIKELEVEKLSSVTEDSTAQTCKLITLLLRSSKSEDLRLSIPVDFTVKDLIKRYCTEVKISFHERIRLEFEGEWLDPNDQVQSTELEDEDQVSVVLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationYAKQLIASSSDSEEE
HHHHHHHCCCCCHHH		24.3124763107
31PhosphorylationAKQLIASSSDSEEES
HHHHHHCCCCCHHHH		29.1924763107
32PhosphorylationKQLIASSSDSEEESE
HHHHHCCCCCHHHHH		42.5324763107
34PhosphorylationLIASSSDSEEESELD
HHHCCCCCHHHHHHH		49.1824763107
72PhosphorylationEPLSRQSTILDADEG
CCCCCCCEEEECCCC		19.7427738172
86PhosphorylationGNQDVSDTTPNACLN
CCCCCCCCCCCHHHC		36.3227738172
98PhosphorylationCLNEGRHSPKSAISC
HHCCCCCCCCHHHCC		32.4429996109
104PhosphorylationHSPKSAISCVTQPVS
CCCCHHHCCCCCCCC		11.4029996109
107PhosphorylationKSAISCVTQPVSPVY
CHHHCCCCCCCCCCC		31.3325720772
111PhosphorylationSCVTQPVSPVYNTRA
CCCCCCCCCCCCHHH		18.4828889911
116PhosphorylationPVSPVYNTRAAANLR
CCCCCCCHHHHHHHH		12.1925720772
126PhosphorylationAANLRNNSINSEAAL
HHHHHCCCCCHHHHH		27.0525720772
129PhosphorylationLRNNSINSEAALSTT
HHCCCCCHHHHHHHH		27.2625720772
161PhosphorylationQVQEFEKSSSDMDVQ
HHHHHHHCCCCCCEE		28.0721712547
162PhosphorylationVQEFEKSSSDMDVQI
HHHHHHCCCCCCEEE		41.2321712547
163PhosphorylationQEFEKSSSDMDVQIH
HHHHHCCCCCCEEEE		44.0127738172
171PhosphorylationDMDVQIHTHKREIEE
CCCEEEEECEECCCC		30.6221712547
183PhosphorylationIEEDDDNTSADVPLL
CCCCCCCCCCCCCCE		32.0824763107
184PhosphorylationEEDDDNTSADVPLLK
CCCCCCCCCCCCCEE		28.8225720772
195PhosphorylationPLLKHSKSDHSTLYH
CCEECCCCCCCCEEC		43.5024763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD60_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD60_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD60_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HUS2_SCHPOrqh1genetic
16880212
EME1_SCHPOeme1genetic
16880212
MUS81_SCHPOmus81genetic
12897162
RAD57_SCHPOrad57genetic
16354704
RAD60_SCHPOrad60physical
16880212
SMC5_SCHPOsmc5physical
12897162
SLX8_SCHPOslx8physical
17762865
SMC6_SCHPOsmc6genetic
19755492
BRC1_SCHPObrc1genetic
15485909
SMC6_SCHPOsmc6genetic
15485909
NSE4_SCHPOnse4genetic
15485909
TOP2_SCHPOtop2genetic
19528228
FEN1_SCHPOrad2genetic
11971984
RAD18_SCHPOrhp18genetic
11971984
SFR1_SCHPOsfr1genetic
18769921
PMT3_SCHPOpmt3genetic
21444718
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD60_SCHPO

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Related Literatures of Post-Translational Modification

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