| UniProt ID | RAD18_SCHPO | |
|---|---|---|
| UniProt AC | O74747 | |
| Protein Name | Postreplication repair E3 ubiquitin-protein ligase rad18 | |
| Gene Name | rhp18 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 387 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity).. | |
| Protein Sequence | MNELDATDPSDWNQTKIPSLKGLDSSLRCLICHEYFRAPLITSCSHTFCSFCIRDYLREHPMCPACRAPEQESRLRKNTILEEILESFKVIRPTLFEFLKVENVPKPVLQAPETVIAQDSASGDEEWEDDLASNSSPASIAKKTSRDSKKRKREDLVHCPACSNLVPHNQINQHLDSCLNSPSSPSSSSSPYKNKDNSKSNSLLSFKTDDDSITKRRLRSFNSADELPLKDRVRLPKLTYALLSESKIRSKLSEMGLPTDGHKQLLQRRHAKWVTLYNSNLDQKQPVSKRNLIRQLIDWERVQSKSIGVEKEKLGGGDWEKAYAEDFADLINRAKQSTTNKNDSLRNTAVESSTEPSTSNGFPATSVSPPLTIDLTNSQTGSDGPQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 200 | Phosphorylation | KNKDNSKSNSLLSFK CCCCCCCCCCCCCEE | 31.32 | 21712547 | |
| 202 | Phosphorylation | KDNSKSNSLLSFKTD CCCCCCCCCCCEECC | 37.47 | 21712547 | |
| 205 | Phosphorylation | SKSNSLLSFKTDDDS CCCCCCCCEECCCCH | 29.95 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAD18_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAD18_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAD18_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NSE6_SCHPO | nse6 | genetic | 18931302 | |
| RAD57_SCHPO | rad57 | genetic | 18931302 | |
| RHP41_SCHPO | rhp41 | genetic | 18931302 | |
| TLG2_SCHPO | tlg2 | genetic | 18931302 | |
| HSK1_SCHPO | hsk1 | genetic | 20176980 | |
| RAD13_SCHPO | rad13 | genetic | 11523791 | |
| UVE1_SCHPO | uve1 | genetic | 11523791 | |
| HUS2_SCHPO | rqh1 | genetic | 11523791 | |
| RAD3_SCHPO | rad3 | genetic | 11523791 | |
| CHK1_SCHPO | chk1 | genetic | 11523791 | |
| UBC2_SCHPO | rhp6 | genetic | 11523791 | |
| RAD60_SCHPO | rad60 | genetic | 11971984 | |
| RAD18_SCHPO | rhp18 | physical | 23695164 | |
| RAD18_SCHPO | rhp18 | physical | 26771498 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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