HSK1_SCHPO - dbPTM
HSK1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HSK1_SCHPO
UniProt AC P50582
Protein Name Cell cycle serine/threonine-protein kinase hsk1
Gene Name hsk1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 507
Subcellular Localization Nucleus . Nuclear throughout the cell cycle.
Protein Description Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity..
Protein Sequence MAEAHITLSPKVTHEQQTDIDSECEITEVDDENVNENKSQEMIQDIPARDREEIENITRTFVELQENYRLIEKIGEGTFSSVYKAEDLHYGRYINDWDIQSEVLKESSFGKEKIPVNEDSRKPKYVAIKKIYATSSPARIYNELEILYLLRGSSVIAPLITALRNEDQVLVVLPYYEHTDFRQYYSTFSYRDMSIYFRCLFQAMQQTQTLGIIHRDIKPSNFLFDVRTKHGVLVDFGLAERYDGRQQSHSCRCTNSNAAELAHDFSIAQETSLGYIKNDTRPSKRANRAGTRGFRAPEVLFKCSSQSPKVDIWSAGVILLSFLTKRFPMFNSKDDVDALMEIACIFGKSEMRQCAALHGCTFETNVSTLTEKRVNFRKLILWASCGSASIYKEKLRHKPSQEERLCLDFLEKCLELDCNKRISAEEALDHDFLYLDNLAYEKKDDDTAFDNSFGETSFEKDEDLTAKHLSHILDFKEQEETDEPTSLSKRKRSIDEILPNDALQDGA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationAEAHITLSPKVTHEQ
CCEEEEECCCCCCCC		17.6428889911
18PhosphorylationKVTHEQQTDIDSECE
CCCCCCCCCCCCCCE		34.3225720772
22PhosphorylationEQQTDIDSECEITEV
CCCCCCCCCCEEEEC		44.4728889911
39PhosphorylationENVNENKSQEMIQDI
CCCCCCCCHHHHHHC		42.8529996109
291PhosphorylationKRANRAGTRGFRAPE
HHHCCCCCCCCCCCH		27.00-
452PhosphorylationDDTAFDNSFGETSFE
CCCCCCCCCCCCCCC		36.1521712547
456PhosphorylationFDNSFGETSFEKDED
CCCCCCCCCCCCCCC		38.8124763107
457PhosphorylationDNSFGETSFEKDEDL
CCCCCCCCCCCCCCC		27.4021712547
465PhosphorylationFEKDEDLTAKHLSHI
CCCCCCCHHHHHHHH		46.0825720772
493PhosphorylationSLSKRKRSIDEILPN
CHHHHHCCHHHHCCC		37.1111359920
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HSK1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HSK1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HSK1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IBP1_SCHPOibp1genetic
14508607
CDS1_SCHPOcds1genetic
14508607
CDS1_SCHPOcds1genetic
11027263
MCM2_SCHPOmcm2genetic
11359920
RAD3_SCHPOrad3genetic
11359920
CDS1_SCHPOcds1genetic
11359920
RAD21_SCHPOrad21genetic
11359920
ESO1_SCHPOeso1genetic
11359920
ORC1_SCHPOorc1genetic
11027263
RAD4_SCHPOrad4genetic
11027263
MCM2_SCHPOmcm2genetic
11027263
MCM6_SCHPOmcm6genetic
11027263
MCM10_SCHPOcdc23genetic
11027263
CDC24_SCHPOcdc24genetic
11027263
MPIP_SCHPOcdc25genetic
11027263
HUS2_SCHPOrqh1genetic
11027263
RAD21_SCHPOrad21genetic
11027263
RAD3_SCHPOrad3genetic
11027263
CHK1_SCHPOchk1genetic
11027263
SWI1_SCHPOswi1genetic
16263721
CHK1_SCHPOchk1genetic
16263721
SWI6_SCHPOswi6physical
14625560
CDC45_SCHPOcdc45physical
15338237
MCM2_SCHPOmcm2physical
12604790
HSK1_SCHPOhsk1physical
12604790
MCM2_SCHPOmcm2physical
9705352
MCM2_SCHPOmcm2physical
14508607
HIM1_SCHPOdfp1physical
9705352
HIM1_SCHPOdfp1physical
12052858
HIM1_SCHPOdfp1physical
11402029
HIM1_SCHPOdfp1genetic
11359920
HIM1_SCHPOdfp1physical
20230746
AMS2_SCHPOams2physical
20230746
RAD1_SCHPOrad1genetic
20176980
RAD17_SCHPOrad17genetic
20176980
RHP9_SCHPOcrb2genetic
20176980
MCM2_SCHPOmcm2genetic
20176980
CDS1_SCHPOcds1genetic
20176980
MRC1_SCHPOmrc1genetic
20176980
RAD18_SCHPOrhp18genetic
20176980
UBC13_SCHPOubc13genetic
20176980
MRC1_SCHPOmrc1physical
21099360
RAD4_SCHPOrad4physical
21095590
MRC1_SCHPOmrc1genetic
22024164
CDS1_SCHPOcds1genetic
22024164
MRC1_SCHPOmrc1genetic
22279046
RIF1_SCHPOrif1genetic
22279046
TAZ1_SCHPOtaz1genetic
22279046
MCL1_SCHPOmcl1genetic
22681890
HIM1_SCHPOdfp1physical
10409743
RIF1_SCHPOrif1genetic
24656819
MRC1_SCHPOmrc1genetic
28069740
MRC1_SCHPOmrc1physical
28069740
RIF1_SCHPOrif1genetic
27320927
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HSK1_SCHPO

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-493, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory