ORC1_SCHPO - dbPTM
ORC1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORC1_SCHPO
UniProt AC P54789
Protein Name Origin recognition complex subunit 1
Gene Name orc1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 707
Subcellular Localization Nucleus.
Protein Description Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner..
Protein Sequence MPRRKSLRSQLLINGIDKSLLSDDSADSSDIDEEEVYGVWTEEPFQKEAGRSYYRSLKKNDVIYRVGDDITVHDGDSSFYLGVICKLYEKAIDKHSGKKYVEAIWYSRAYAKRMEIKPEYLLPDRHINEVYVSCGRDENLTSCIIEHCNVYSEAEFFSKFPAGIPTKRKDLFPCNFFIRRGVHLKVNKYTEPLDWSYYAHNLERIEDLLVEMEENLRPTKKKSGSRGRGRPRKYPLPNVESKESSSKVNSKDENFDLQDDSESSEDNLTIQPQTPRRRHKRSRHNSSNLASTPKRNGYKQPLQITPLPIRMLSLEEFQGSPHRKARAMLHVASVPSTLQCRDNEFSTIFSNLESAIEEETGACLYISGTPGTGKTATVHEVIWNLQELSREGQLPEFSFCEINGMRVTSANQAYSILWESLTGERVTPIHAMDLLDNRFTHASPNRSSCVVLMDELDQLVTHNQKVLYNFFNWPSLPHSRLIVVAVANTMDLPERILSNRISSRLGLSRVPFEPYTHTQLEIIIAARLEAVRDDDVFSSDAIRFAARKVAAVSGDARRALDICRRASELAENKNGKVTPGLIHQAISEMTASPLQKVLRNLSFMQKVFLCAIVNRMRRSGFAESYVYEVLEEAERLLRVMTTPDAEAKFGELILRRPEFGYVLSSLSENGVLYLENKSSRNARVRLAIADDEIKLAFRGDSELAGIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MPRRKSLRSQLLI
--CCCCHHHHHHHHH		27.4924763107
9PhosphorylationPRRKSLRSQLLINGI
CCCHHHHHHHHHCCC		30.3921712547
261PhosphorylationNFDLQDDSESSEDNL
CCCCCCCCCCCCCCC		47.9025720772
263PhosphorylationDLQDDSESSEDNLTI
CCCCCCCCCCCCCCC		42.8725720772
264PhosphorylationLQDDSESSEDNLTIQ
CCCCCCCCCCCCCCC		44.9425720772
286PhosphorylationHKRSRHNSSNLASTP
CCCCCCCCCCCCCCC		17.9325720772
287PhosphorylationKRSRHNSSNLASTPK
CCCCCCCCCCCCCCC		40.9729996109
291PhosphorylationHNSSNLASTPKRNGY
CCCCCCCCCCCCCCC		48.7028889911
292PhosphorylationNSSNLASTPKRNGYK
CCCCCCCCCCCCCCC		27.5028889911
305PhosphorylationYKQPLQITPLPIRML
CCCCCEECCCCEEEC		13.0529996109
313PhosphorylationPLPIRMLSLEEFQGS
CCCEEECCHHHHCCC		25.1321712547
320PhosphorylationSLEEFQGSPHRKARA
CHHHHCCCHHHHHHH		13.5228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORC1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORC1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORC1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC18_SCHPOcdc18genetic
11988741
DPOA2_SCHPOspb70genetic
15314153
CDK1_SCHPOcdc2genetic
12186947
WEE1_SCHPOwee1genetic
12186947
ORC2_SCHPOorc2physical
10535928
ORC5_SCHPOorc5physical
10535928
ORC1_SCHPOorc1physical
11683912
ORC2_SCHPOorc2physical
11683912
ORC4_SCHPOorc4physical
11683912
ORC5_SCHPOorc5physical
11683912
ORC2_SCHPOorc2physical
11850415
ORC3_SCHPOorc3physical
11850415
ORC4_SCHPOorc4physical
11850415
ORC5_SCHPOorc5physical
11850415
ORC6_SCHPOorc6physical
11850415
CDC45_SCHPOcdc45physical
15338237
SWI1_SCHPOswi1genetic
18667534
SWI3_SCHPOswi3genetic
18667534
CDS1_SCHPOcds1genetic
18667534
CHK1_SCHPOchk1genetic
18667534
RAD1_SCHPOrad1genetic
18667534
RAD9_SCHPOrad9genetic
18667534
RAD3_SCHPOrad3genetic
18667534
RAD26_SCHPOrad26genetic
18667534
RAD17_SCHPOrad17genetic
18667534
MRC1_SCHPOmrc1genetic
18667534
RHP9_SCHPOcrb2genetic
18667534
MUS81_SCHPOmus81genetic
18667534
HUS2_SCHPOrqh1genetic
18667534
RAD24_SCHPOrad24genetic
18667534
CDC18_SCHPOcdc18physical
8895665
BRC1_SCHPObrc1genetic
22366461
CHK1_SCHPOchk1genetic
16849602
MRC1_SCHPOmrc1genetic
16849602
RAD1_SCHPOrad1genetic
12186947
RAD3_SCHPOrad3genetic
12186947
RAD17_SCHPOrad17genetic
12186947
RAD26_SCHPOrad26genetic
12186947
CHK1_SCHPOchk1genetic
12186947
CDC18_SCHPOcdc18genetic
12186947
CG22_SCHPOcig2genetic
15194812
RUM1_SCHPOrum1genetic
15194812
MRC1_SCHPOmrc1genetic
20799962
CHK1_SCHPOchk1genetic
20799962
CDC18_SCHPOcdc18genetic
8895665
TAS3_SCHPOtas3physical
26771498
BRC1_SCHPObrc1genetic
28718400
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORC1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291; THR-292 ANDSER-320, AND MASS SPECTROMETRY.

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