| UniProt ID | CDC18_SCHPO | |
|---|---|---|
| UniProt AC | P41411 | |
| Protein Name | Cell division control protein 18 | |
| Gene Name | cdc18 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 577 | |
| Subcellular Localization | ||
| Protein Description | Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint.. | |
| Protein Sequence | MCETPIGCHTPRRCNRFIDSAALIDCTNKTNQREHSPSFSIEIPTTPSRKRTLASSHFQTPTKRIKYELGELQEEKTDLYPNFPAQLKENKKPKLPTTPQTPKTPKRTIQIVTPKSLNRTCNPVPFATRLLQSTPHRQLFPPTPSTPSTPSYNSTAKLSLRKSYRSAGVVGRENEKSIVESFFRQHLDANAGGALYVSGAPGTGKTVLLHNVLDHVVSDYPKVNVCYINCMTINEPKAIFEKIHSKIVKEEILENEDHHINFQCELESHFTQSANELYNPVIIVLDEMDHLIAREQQVLYTLFEWPSRPTSRLILVGIANALDMTDRFLPRLRTKHITPKLLSFTPYTAQEISTIIKARLKTAATTSEKNNPFTPIKSISEVSDDSINVVSQHADETPFIHPAAIELCARKVAASSGDLRKALDICRHAIELAEREWKAQHDNTLSSVDIPRASIAHVVRATSAMSQSASARLKNLGLQQKAILCTLVVCEKTSLSVADVFEKYSSLCLRDRLIYPLTSSEFCDVANSLETLAIIRLRTKQRNGKPQDRIISLLVPEMDVITAVGDIGTLKRFFDRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | KTNQREHSPSFSIEI CCCCCCCCCCEEEEC | 19.93 | 25720772 | |
| 38 | Phosphorylation | NQREHSPSFSIEIPT CCCCCCCCEEEECCC | 34.34 | 25720772 | |
| 40 | Phosphorylation | REHSPSFSIEIPTTP CCCCCCEEEECCCCC | 24.53 | 29996109 | |
| 45 | Phosphorylation | SFSIEIPTTPSRKRT CEEEECCCCCCHHHC | 57.93 | 25720772 | |
| 46 | Phosphorylation | FSIEIPTTPSRKRTL EEEECCCCCCHHHCC | 17.57 | 25720772 | |
| 56 | Phosphorylation | RKRTLASSHFQTPTK HHHCCHHHCCCCCHH | 23.78 | 29996109 | |
| 60 | Phosphorylation | LASSHFQTPTKRIKY CHHHCCCCCHHHHCH | 31.79 | 29996109 | |
| 97 | Phosphorylation | NKKPKLPTTPQTPKT CCCCCCCCCCCCCCC | 62.64 | 21712547 | |
| 98 | Phosphorylation | KKPKLPTTPQTPKTP CCCCCCCCCCCCCCC | 16.09 | 24763107 | |
| 101 | Phosphorylation | KLPTTPQTPKTPKRT CCCCCCCCCCCCCCE | 28.14 | 24763107 | |
| 104 | Phosphorylation | TTPQTPKTPKRTIQI CCCCCCCCCCCEEEE | 34.93 | 24763107 | |
| 113 | Phosphorylation | KRTIQIVTPKSLNRT CCEEEEECCHHHCCC | 26.99 | 25720772 | |
| 116 | Phosphorylation | IQIVTPKSLNRTCNP EEEECCHHHCCCCCC | 31.89 | 25720772 | |
| 134 | Phosphorylation | ATRLLQSTPHRQLFP HHHHHHCCCCCCCCC | 15.34 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | pop2#pop1 | O14170#P87060 | PMID:22199232 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC18_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC18_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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