dbPTM

ORC3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ORC3_SCHPO
UniProt AC	Q10067
Protein Name	Origin recognition complex subunit 3
Gene Name	orc3
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	690
Subcellular Localization	Nucleus.
Protein Description	Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner..
Protein Sequence	MSAILQYDSVSKGTYSVKPKPTESLGNEFSEGLFVPLIGGKEPIEYVKLRENLCTKVLNELEEITTHTTYDSNARVLRQLCEHASEPVDETGLLRTAIVCDKSSNSMHLKFYEQLKDDMEKIGWKNFVVLNLKAHRDLKSCFRVIKGGSFGLGVLSYDIEKLDEKTVLVLEDVEDCDRRLLSSLVEALSSLVRHSKLQGCLYTIFNLKIPLEMFDTSLDSKFLSNVKTKVFNMKASTEILESLFTSIEESLSLKFGWRTRRFFRSMFYERSWSVERVIECIRYSILTHFYGNALSIIEHLIYQKDFHLISPLHLTTLRTVPSFQRHIEQRLEIGDLESINYVEKMLNDDTYFQEMVIQMCENLLYRERLLRTQAKIWHELEMAVKTTTRISFADYLETFLQGDWLSSPQYKSICQAILRMNSTKALACLDYLNENIFTGNQTMKCLEIHQELSELIRNSSTNYLEPVEVRMQNYSGTKHTRKVVESGFDKSIIDFSKILKKIVGLLDEEVQYGCLGTESIDMYPFYEVLFYDYCRPLNQAFASGHQRSVIHSSCMDPEYYVGDEKKIDSEFSNAEKDGKDLISWLPDLSILYKLYSESGALLNLYDWYIAFSEHLQAGKENLKEDDNHPRESPQGNLQRELNELDEDKRKLEEAKLQSRFLFGLEELRFLGLIKPTARKTDHVMKTIYHQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
632	Phosphorylation	DDNHPRESPQGNLQR CCCCCCCCCCHHHHH	24.65	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ORC3_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ORC3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ORC3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ORC4_SCHPO	orc4	physical	11850415
ORC5_SCHPO	orc5	physical	11850415
ORC6_SCHPO	orc6	physical	11850415

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ORC3_SCHPO

Related Literatures of Post-Translational Modification