ORC4_SCHPO - dbPTM
ORC4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORC4_SCHPO
UniProt AC Q9Y794
Protein Name Origin recognition complex subunit 4
Gene Name orc4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 972
Subcellular Localization Nucleus.
Protein Description Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. This binding is mediated by the N-terminal A.T hook repeats of orc4..
Protein Sequence MSSSPFTNLGNLDTEAIYENKENEYQTNITNETSNVQNLSSGNDDQQYPNSTNDDANNGLTASQAKLQDIAAVTLFQDNNISTTTLAPPSPSPLRLNEAPRRRGRPRKYPPKPIDEGSEPIIKRKRGRPPKIKSSSPSTKLDDPLKPKRGRGRPRLHPLPVVQPSVDEGTTQNNLQMGLDEPNIIEGFAEGHANLSELKPKRGRGRPRKIKPEEGSSSQNGLSPLVVLPAKRGRGRPPLHRSEQKIANTPISNNVTVESTGTNLHTHSQLNPENEQSSSEFYSLNPQSEIRKEVVVTDQPLFSTADVPVKRKRGRPPLNKPKILFGTSTENKIDENRPKRGRGRPRLERPSGLPLDSKSQSLFKRKRGRPPKIASGIVPLSAFTRKHEDMLHDSDALSLKHFAITSPNNQQFLNNQQRESAPLLPRKRGRPPKKRQENAEIRNITPGLTDSSVHSSSATPQSESSSPNSVSPLLPSSDRLPLLRQSQFTPPPKKPNFEVAIISPKKSQHKLYPNPVVESVFNDVPYSEIDSQLHTIKSTIAARLCGKSHIPLVGHMDEQTKLYQWVRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYQTDDKLALREISRQLSIELESIESDEALKSEMNFSDTLTKLLATLSHPVDLGIAEDVMTTSAAVIFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASGALAHSSRLWGRDVALEAWETLGSIGLIIPVHPSTNVSGALSRQCQLWQPEVDINVVSVGLREHRRLPSHYYRWLKEVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSPFTNL
------CCCCCCCCC		39.2521712547
3Phosphorylation-----MSSSPFTNLG
-----CCCCCCCCCC		40.5121712547
4Phosphorylation----MSSSPFTNLGN
----CCCCCCCCCCC		19.4121712547
134PhosphorylationGRPPKIKSSSPSTKL
CCCCCCCCCCCCCCC		39.2525720772
136PhosphorylationPPKIKSSSPSTKLDD
CCCCCCCCCCCCCCC		29.9325720772
138PhosphorylationKIKSSSPSTKLDDPL
CCCCCCCCCCCCCCC		39.8725720772
139PhosphorylationIKSSSPSTKLDDPLK
CCCCCCCCCCCCCCC		38.7227738172
223PhosphorylationSSSQNGLSPLVVLPA
CCCCCCCCCEEEEEC		20.0024763107
375PhosphorylationGRPPKIASGIVPLSA
CCCCCHHHCCCCHHH		32.3129996109
381PhosphorylationASGIVPLSAFTRKHE
HHCCCCHHHHHCCHH		18.4421712547
384PhosphorylationIVPLSAFTRKHEDML
CCCHHHHHCCHHHHC		38.2321712547
405PhosphorylationSLKHFAITSPNNQQF
CCCEEEEECCCHHHH		34.4028889911
406PhosphorylationLKHFAITSPNNQQFL
CCEEEEECCCHHHHH		21.3728889911
420PhosphorylationLNNQQRESAPLLPRK
HHHCCHHCCCCCCCC		37.0621712547
503PhosphorylationNFEVAIISPKKSQHK
CEEEEEECCCCCCCC		25.2628889911
519PhosphorylationYPNPVVESVFNDVPY
CCCCHHHHHHCCCCH		22.0221712547
526PhosphorylationSVFNDVPYSEIDSQL
HHHCCCCHHHHHHHH		20.8421712547
531PhosphorylationVPYSEIDSQLHTIKS
CCHHHHHHHHHHHHH		40.0621712547
535PhosphorylationEIDSQLHTIKSTIAA
HHHHHHHHHHHHHHH		38.4021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORC4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORC4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORC4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ORC2_SCHPOorc2physical
10535928
ORC1_SCHPOorc1physical
10535928
ORC3_SCHPOorc3physical
10535928
ORC5_SCHPOorc5physical
10535928
ORC6_SCHPOorc6physical
10535928
ORC1_SCHPOorc1physical
11717425
ORC2_SCHPOorc2physical
11717425
ORC3_SCHPOorc3physical
11717425
ORC5_SCHPOorc5physical
11717425
ORC6_SCHPOorc6physical
11717425
ORC1_SCHPOorc1physical
11689699
ORC1_SCHPOorc1physical
12840006
ORC2_SCHPOorc2physical
11689699
ORC2_SCHPOorc2physical
12840006
ORC6_SCHPOorc6physical
11689699
ORC5_SCHPOorc5physical
11850415
ORC6_SCHPOorc6physical
11850415
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORC4_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-405; SER-406 ANDSER-503, AND MASS SPECTROMETRY.

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