ORC2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ORC2_SCHPO
• UniProt AC: Q09142
• Protein Name: Origin recognition complex subunit 2
• Gene Name: orc2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 535
• Subcellular Localization: Nucleus.
• Protein Description: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner..
• Protein Sequence: MLINEHVRERYHFLRVSLTRVAHLVFANSHESNDLKMVENVSSTPKKGVLEDPSTLTPEVVTPRTPGHRIIKAKGAYTKDRSAKRRRGRIEIERHLLGEFDDNVGSNSLLDVPLYSLEAEPLSPSVMLEDESMEGINQSPQGISVEKLGKEDNRSRSSTPASPSLESHEFSESREAGLSQSNGFEARSHGTGFDEYFDKFSQRKTSSNTLSQLPVLDNQVYLDTVKEICTETEQHTQTLVHFQSRNFHQWYFELVNNFNLLFYGFGSKEHFLSSFVEKKLPCFPIFVVKGYFPQLQLKNVLSSFLEFLEVTPAASVSDMLIQSLSIINSPSFSLGKIVFLVHNIDGESLIDERFQSALAAIASSKNVYFIASVDHVNFALLWDTSLESSFNFVMHDATTFARYYNETTYENSLGIGRANVSNKEKAIKHVLYSLPANSRGIFKFLLIHQLERMMDTQDFDARQGEKVGIEYRSFFQKCSAEFLCSNEPNFRSQLTEFFDHNIIESKRDVSNSEILWVPYPKNLLEILLEDMMEDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	MVENVSSTPKKGVLE EEEECCCCCCCCCCC	31.46	27738172
54	Phosphorylation	KGVLEDPSTLTPEVV CCCCCCCCCCCCCCC	48.66	21712547
55	Phosphorylation	GVLEDPSTLTPEVVT CCCCCCCCCCCCCCC	39.79	21712547
57	Phosphorylation	LEDPSTLTPEVVTPR CCCCCCCCCCCCCCC	19.93	21712547
62	Phosphorylation	TLTPEVVTPRTPGHR CCCCCCCCCCCCCCE	16.54	21712547
65	Phosphorylation	PEVVTPRTPGHRIIK CCCCCCCCCCCEEEE	34.52	21712547
155	Phosphorylation	LGKEDNRSRSSTPAS CCCCCCCCCCCCCCC	42.65	29996109
157	Phosphorylation	KEDNRSRSSTPASPS CCCCCCCCCCCCCCC	39.55	29996109
158	Phosphorylation	EDNRSRSSTPASPSL CCCCCCCCCCCCCCH	36.98	25720772
159	Phosphorylation	DNRSRSSTPASPSLE CCCCCCCCCCCCCHH	24.91	29996109
162	Phosphorylation	SRSSTPASPSLESHE CCCCCCCCCCHHHCC	19.07	28889911
164	Phosphorylation	SSTPASPSLESHEFS CCCCCCCCHHHCCCC	42.12	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ORC2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ORC2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ORC2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD1_SCHPO	rad1	genetic	10655214
RAD3_SCHPO	rad3	genetic	10655214
ORC3_SCHPO	orc3	physical	10535928
ORC4_SCHPO	orc4	physical	10535928
ORC1_SCHPO	orc1	physical	10535928
ORC5_SCHPO	orc5	physical	10535928
ORC6_SCHPO	orc6	physical	10535928
ORC4_SCHPO	orc4	physical	11717425
ORC1_SCHPO	orc1	physical	11717425
ORC3_SCHPO	orc3	physical	11717425
ORC5_SCHPO	orc5	physical	11717425
ORC6_SCHPO	orc6	physical	11717425
ORC1_SCHPO	orc1	physical	11683912
ORC2_SCHPO	orc2	physical	11683912
ORC4_SCHPO	orc4	physical	11683912
ORC5_SCHPO	orc5	physical	11683912
ORC3_SCHPO	orc3	physical	11850415
ORC4_SCHPO	orc4	physical	11850415
ORC5_SCHPO	orc5	physical	11850415
ORC6_SCHPO	orc6	physical	11850415
ORC1_SCHPO	orc1	physical	10523506
SWI1_SCHPO	swi1	genetic	18667534
SWI3_SCHPO	swi3	genetic	18667534
CDK1_SCHPO	cdc2	physical	8552194
CDC18_SCHPO	cdc18	physical	8552194

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.