CG23_SCHPO - dbPTM
CG23_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CG23_SCHPO
UniProt AC P10815
Protein Name G2/mitotic-specific cyclin cdc13
Gene Name cdc13
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 482
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein Description Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1..
Protein Sequence MTTRRLTRQHLLANTLGNNDENHPSNHIARAKSSLHSSENSLVNGKKATVSSTNVPKKRHALDDVSNFHNKEGVPLASKNTNVRHTTASVSTRRALEEKSIIPATDDEPASKKRRQPSVFNSSVPSLPQHLSTKSHSVSTHGVDAFHKDQATIPKKLKKDVDERVVSKDIPKLHRDSVESPESQDWDDLDAEDWADPLMVSEYVVDIFEYLNELEIETMPSPTYMDRQKELAWKMRGILTDWLIEVHSRFRLLPETLFLAVNIIDRFLSLRVCSLNKLQLVGIAALFIASKYEEVMCPSVQNFVYMADGGYDEEEILQAERYILRVLEFNLAYPNPMNFLRRISKADFYDIQTRTVAKYLVEIGLLDHKLLPYPPSQQCAAAMYLAREMLGRGPWNRNLVHYSGYEEYQLISVVKKMINYLQKPVQHEAFFKKYASKKFMKASLFVRDWIKKNSIPLGDDADEDYTFHKQKRIQHDMKDEEW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationNHIARAKSSLHSSEN
HHHHHHHHHHHCCCC
36.8321712547
34PhosphorylationHIARAKSSLHSSENS
HHHHHHHHHHCCCCC
29.4221712547
37PhosphorylationRAKSSLHSSENSLVN
HHHHHHHCCCCCCCC
44.6421712547
38PhosphorylationAKSSLHSSENSLVNG
HHHHHHCCCCCCCCC
30.0124763107
41PhosphorylationSLHSSENSLVNGKKA
HHHCCCCCCCCCEEC
29.6421712547
66PhosphorylationRHALDDVSNFHNKEG
HCCCCCHHHCCCCCC
40.5521712547
111PhosphorylationATDDEPASKKRRQPS
CCCCCCCHHHHCCCC
49.8021712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CG23_SCHPO !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CG23_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CG23_SCHPO !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOP3_SCHPOtop3genetic
12023299
HUS2_SCHPOrqh1genetic
12023299
PUC1_SCHPOpuc1genetic
1828291
CGM2_SCHPOmcs2genetic
2474475
CRK1_SCHPOmcs6genetic
2474475
CDC10_SCHPOcdc10genetic
10388806
MCM2_SCHPOmcm2genetic
10388806
CG22_SCHPOcig2genetic
9436991
CG22_SCHPOcig2genetic
8631306
CDK1_SCHPOcdc2physical
9632761
RUM1_SCHPOrum1physical
9614176
CDK1_SCHPOcdc2physical
9790601
CDC11_SCHPOcdc11physical
15062098
CDK1_SCHPOcdc2physical
10581266
WOS2_SCHPOwos2physical
10581266
CDK1_SCHPOcdc2physical
16390871
CG22_SCHPOcig2genetic
8657126
CDK1_SCHPOcdc2genetic
2847913
BIR1_SCHPObir1genetic
20739936
SLP1_SCHPOslp1physical
15791259
ELP3_SCHPOelp3genetic
22768388
CTU1_SCHPOctu1genetic
22768388
NUP60_SCHPOnup60genetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
PDE1_SCHPOcgs2genetic
22681890
RL7B_SCHPOrpl702genetic
22681890
ORC2_SCHPOorc2physical
23695164
CDC11_SCHPOcdc11physical
23695164
CDK1_SCHPOcdc2genetic
1829983
ORC2_SCHPOorc2genetic
8552194
CDK1_SCHPOcdc2physical
2569363
CG22_SCHPOcig2genetic
8455610
MPIP_SCHPOcdc25genetic
8455610
ATF1_SCHPOatf1genetic
24728197
CG23_SCHPOcdc13physical
26771498
ORC2_SCHPOorc2physical
26771498
CDC11_SCHPOcdc11physical
26771498
CDK1_SCHPOcdc2physical
26131711

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CG23_SCHPO

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Related Literatures of Post-Translational Modification

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