| UniProt ID | MPIP_SCHPO | |
|---|---|---|
| UniProt AC | P06652 | |
| Protein Name | M-phase inducer phosphatase | |
| Gene Name | cdc25 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 596 | |
| Subcellular Localization | ||
| Protein Description | This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.. | |
| Protein Sequence | MDSPLSSLSFTNTLSGKRNVLRPAARELKLMSDRNANQELDFFFPKSKHIASTLVDPFGKTCSTASPASSLAADMSMNMHIDESPALPTPRRTLFRSLSCTVETPLANKTIVSPLPESPSNDALTESYFFRQPASKYSITQDSPRVSSTIAYSFKPKASIALNTTKSEATRSSLSSSSFDSYLRPNVSRSRSSGNAPPFLRSRSSSSYSINKKKGTSGGQATRHLTYALSRTCSQSSNTTSLLESCLTDDTDDFELMSDHEDTFTMGKVADLPESSVELVEDAASIQRPNSDFGACNDNSLDDLFQASPIKPIDMLPKINKDIAFPSLKVRSPSPMAFAMQEDAEYDEQDTPVLRRTQSMFLNSTRLGLFKSQDLVCVTPKQSTKESERFISSHVEDLSLPCFAVKEDSLKRITQETLLGLLDGKFKDIFDKCIIIDCRFEYEYLGGHISTAVNLNTKQAIVDAFLSKPLTHRVALVFHCEHSAHRAPHLALHFRNTDRRMNSHRYPFLYYPEVYILHGGYKSFYENHKNRCDPINYVPMNDASHVMTCTKAMNNFKRNATFMRTKSYTFGQSVLASPDVNDSPTAMHSLSTLRRF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MDSPLSSLSF -----CCCCHHHCCC | 26.83 | 24763107 | |
| 11 | Phosphorylation | PLSSLSFTNTLSGKR CHHHCCCCCCCCCCC | 24.74 | 29996109 | |
| 13 | Phosphorylation | SSLSFTNTLSGKRNV HHCCCCCCCCCCCCC | 21.17 | 29996109 | |
| 15 | Phosphorylation | LSFTNTLSGKRNVLR CCCCCCCCCCCCCHH | 39.98 | 24763107 | |
| 97 | Phosphorylation | PRRTLFRSLSCTVET CCHHHHHHCEEEEEC | 19.80 | 29996109 | |
| 99 | Phosphorylation | RTLFRSLSCTVETPL HHHHHHCEEEEECCC | 14.69 | 28889911 | |
| 101 | Phosphorylation | LFRSLSCTVETPLAN HHHHCEEEEECCCCC | 20.28 | 29996109 | |
| 104 | Phosphorylation | SLSCTVETPLANKTI HCEEEEECCCCCCEE | 21.19 | 29996109 | |
| 110 | Phosphorylation | ETPLANKTIVSPLPE ECCCCCCEEEECCCC | 26.81 | 21712547 | |
| 113 | Phosphorylation | LANKTIVSPLPESPS CCCCEEEECCCCCCC | 19.50 | 24763107 | |
| 118 | Phosphorylation | IVSPLPESPSNDALT EEECCCCCCCCCCCC | 31.52 | 24763107 | |
| 120 | Phosphorylation | SPLPESPSNDALTES ECCCCCCCCCCCCHH | 57.53 | 25720772 | |
| 125 | Phosphorylation | SPSNDALTESYFFRQ CCCCCCCCHHHCCCC | 25.30 | 21712547 | |
| 137 | Phosphorylation | FRQPASKYSITQDSP CCCCCHHCCCCCCCC | 11.65 | 29996109 | |
| 143 | Phosphorylation | KYSITQDSPRVSSTI HCCCCCCCCCEECEE | 12.56 | 29996109 | |
| 153 | Phosphorylation | VSSTIAYSFKPKASI EECEEEEECCCCCEE | 20.12 | 24763107 | |
| 172 | Phosphorylation | TKSEATRSSLSSSSF CCCHHHHHHCCCCCH | 31.14 | 25720772 | |
| 176 | Phosphorylation | ATRSSLSSSSFDSYL HHHHHCCCCCHHHHC | 34.98 | 25720772 | |
| 178 | Phosphorylation | RSSLSSSSFDSYLRP HHHCCCCCHHHHCCC | 34.71 | 28889911 | |
| 181 | Phosphorylation | LSSSSFDSYLRPNVS CCCCCHHHHCCCCCC | 24.85 | 29996109 | |
| 192 | Phosphorylation | PNVSRSRSSGNAPPF CCCCCCCCCCCCCCC | 43.79 | 25720772 | |
| 193 | Phosphorylation | NVSRSRSSGNAPPFL CCCCCCCCCCCCCCC | 34.65 | 28889911 | |
| 202 | Phosphorylation | NAPPFLRSRSSSSYS CCCCCCCCCCCCCEE | 38.37 | 25720772 | |
| 204 | Phosphorylation | PPFLRSRSSSSYSIN CCCCCCCCCCCEEEE | 35.50 | 29996109 | |
| 230 | Phosphorylation | RHLTYALSRTCSQSS HHHHHHHHHHHCCCC | 19.85 | 25720772 | |
| 332 | Phosphorylation | FPSLKVRSPSPMAFA CCCCCCCCCCCCEEH | 32.49 | 25720772 | |
| 334 | Phosphorylation | SLKVRSPSPMAFAMQ CCCCCCCCCCEEHHH | 28.67 | 25720772 | |
| 357 | Phosphorylation | DTPVLRRTQSMFLNS CCHHHHHHHHHHHCC | 20.68 | 25720772 | |
| 359 | Phosphorylation | PVLRRTQSMFLNSTR HHHHHHHHHHHCCCC | 15.76 | 28889911 | |
| 365 | Phosphorylation | QSMFLNSTRLGLFKS HHHHHCCCCCCCCCC | 28.92 | 29996109 | |
| 379 | Phosphorylation | SQDLVCVTPKQSTKE CCCEEEECCCCCCHH | 21.46 | 29996109 | |
| 565 | Phosphorylation | RNATFMRTKSYTFGQ CCCEEEEECEEECCC | 16.74 | 29996109 | |
| 567 | Phosphorylation | ATFMRTKSYTFGQSV CEEEEECEEECCCCE | 28.88 | 21712547 | |
| 569 | Phosphorylation | FMRTKSYTFGQSVLA EEEECEEECCCCEEC | 28.51 | 21712547 | |
| 573 | Phosphorylation | KSYTFGQSVLASPDV CEEECCCCEECCCCC | 21.34 | 21712547 | |
| 577 | Phosphorylation | FGQSVLASPDVNDSP CCCCEECCCCCCCCC | 19.92 | 21712547 | |
| 583 | Phosphorylation | ASPDVNDSPTAMHSL CCCCCCCCCCHHHHH | 20.95 | 21712547 | |
| 585 | Phosphorylation | PDVNDSPTAMHSLST CCCCCCCCHHHHHHH | 40.33 | 21712547 | |
| 591 | Phosphorylation | PTAMHSLSTLRRF-- CCHHHHHHHHCCC-- | 28.54 | 21712547 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPIP_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPIP_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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