WIN1_SCHPO - dbPTM
WIN1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WIN1_SCHPO
UniProt AC O74304
Protein Name MAP kinase kinase kinase win1
Gene Name win1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1436
Subcellular Localization
Protein Description Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation..
Protein Sequence MENILDPSVVNSHILENGSRRSSINPILDSELRDKTFEKAHRRSLTLLSSFTSSMLELPNNGKEENHRRPSVARSSSDRSKASAKEDLFSEAFRMAEQPPAEALTISTPVDPINIDELDRAYAVSPSDTSNLLHPPTSSSSIPIPIKNAGHSNLDHPIRPSLQSSISSNRIIKSPGIKEDDYMHRGRSISSPMIDVEHINSTAVPSKTKNLPEKPKRSHKLRNSITFAKIEDHPERKSQLRRLSSSLKCFDPEYDYNDPSLSIRRDSSTYYFSNVNETYDEEDSDLDSETSTVNWVQSVLNLPSLLSDDLMANPKNKERFEWQYMLTSVLTGDIVRSEKLRLRKIASSREGRNSDYSDNLWMEIWCWLTHRSVDSYRENLKHLRTGMVDVLLAIMNFHWDESNELTPIVAVDNMLQKLDKYERLYPSRRSILQEHSLYASESFQHKLDVLTAYSNVTHALEIQVNIIRSWVGNEEMDITKNTTNSINNVSQISNGPFVERFYRETGLIRAFEQRIMTNMNSVLSKVCNTIVTYADDLKSYGLPLIADDYMRLLSFPFRLIKEFLNLRLSCAENITSISLFTIDSLLDDLRNTMKVAVHIIQQHTVLIKPFRDDSKFVDENQSLNNILVASLKFYFNLLHRKVRNGCALLHFKETEILEGEWDFLLAVCPHIEHGFQIMSKSLSSLVGEILTNINRYLKDQLQGPDTDDSALITSFYIKVLDCVRIRFRKLMSFTRILKAHLENSCEYVIKENSLSLLIQRLEESNHVLTYTASIEHEGAYVIVPGHLVDSPNILREVLSMTFNKGDNNFESVPPYAVVLAPDSSICWNGHVTDLDIPEVSISIAPNCVRLVTLATANQLSVIEDYFISIVGDTVSLVDSAKANSSKINKQMTKIKRNSLKLALSLLDVIQTIRTRYHGMNCQNLIHYSFSYAIEFAQRLMRLSILDASSIGLIRRKMIQLAISWVGFIYEDCSPTDRNTFRWTVTALEFAMIMTYGSNILMIDKKSFEELKEKVGKCVALLLLHFDVMGTKHAGRSMDQQAGDIPARLVRNNSDRSRLSDNELASFVKEEVMHRIIELESNRRDRLYKSQLIGRVLDDTTKENRLLKELASSKSNITIRWQQGGLIGSGSFGTVYRAVNLDTGDLMAVKEVALHKPRISRPMIKRIKGEMLVLELFDHPNVVSYYGIEVHREKVNIFMELCQGSSLFEFLRYGRIEDELVIQVYVLQLLEGLAYIHSCGVSHQDVKPENILFDHNGIMKFTDFGSAKMSGSASTKIFEQLTQQEEEEFEKDSEFLQHLDQNRGYSLTGTPTYMAPELILGNPSERVGAMDIWSLGCVIVEMATGSPPWPRLDNHFSLMYHIAAHNPPIIPADDQLSPLGQNFLKRCFVSDPNQRATAAELLMDPWVYPLRAGTEFDLMNSSVVESAPSTNGAPLEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMENILDPSVVNSHIL
CCCCCCHHHHCHHHH		38.0621712547
12PhosphorylationLDPSVVNSHILENGS
CCHHHHCHHHHCCCC		10.5721712547
19PhosphorylationSHILENGSRRSSINP
HHHHCCCCCCCCCCH		35.7821712547
22PhosphorylationLENGSRRSSINPILD
HCCCCCCCCCCHHCC		34.1625720772
23PhosphorylationENGSRRSSINPILDS
CCCCCCCCCCHHCCH		25.2728889911
44PhosphorylationFEKAHRRSLTLLSSF
HHHHHHHHHHHHHHH		26.1825720772
46PhosphorylationKAHRRSLTLLSSFTS
HHHHHHHHHHHHHHH		27.2229996109
49PhosphorylationRRSLTLLSSFTSSML
HHHHHHHHHHHHHHH		26.9029996109
50PhosphorylationRSLTLLSSFTSSMLE
HHHHHHHHHHHHHHC		32.2929996109
71PhosphorylationEENHRRPSVARSSSD
CCCCCCCCCCCCCCH		26.9729996109
83PhosphorylationSSDRSKASAKEDLFS
CCHHHHHHHHHHHHH		43.5425720772
108PhosphorylationAEALTISTPVDPINI
CHHCEECCCCCCCCH		24.3929996109
125PhosphorylationLDRAYAVSPSDTSNL
CCCEEECCCCCCCCC		15.5429996109
137PhosphorylationSNLLHPPTSSSSIPI
CCCCCCCCCCCCCCE		45.7725720772
152PhosphorylationPIKNAGHSNLDHPIR
ECCCCCCCCCCCCCC		37.8629996109
161PhosphorylationLDHPIRPSLQSSISS
CCCCCCHHHHHHHCC		29.2329996109
164PhosphorylationPIRPSLQSSISSNRI
CCCHHHHHHHCCCCC		34.6329996109
165PhosphorylationIRPSLQSSISSNRII
CCHHHHHHHCCCCCC		17.3325720772
167PhosphorylationPSLQSSISSNRIIKS
HHHHHHHCCCCCCCC		24.4129996109
168PhosphorylationSLQSSISSNRIIKSP
HHHHHHCCCCCCCCC		28.5829996109
174PhosphorylationSSNRIIKSPGIKEDD
CCCCCCCCCCCCCCC		20.2521712547
182PhosphorylationPGIKEDDYMHRGRSI
CCCCCCCCCCCCCCC		13.7221712547
188PhosphorylationDYMHRGRSISSPMID
CCCCCCCCCCCCCCC		29.6421712547
190PhosphorylationMHRGRSISSPMIDVE
CCCCCCCCCCCCCHH		29.6328889911
191PhosphorylationHRGRSISSPMIDVEH
CCCCCCCCCCCCHHH		19.4721712547
224PhosphorylationRSHKLRNSITFAKIE
CCCCCCCCCEEEECC		19.3028889911
226PhosphorylationHKLRNSITFAKIEDH
CCCCCCCEEEECCCC		19.8428889911
238PhosphorylationEDHPERKSQLRRLSS
CCCHHHHHHHHHHHH		40.4421712547
244PhosphorylationKSQLRRLSSSLKCFD
HHHHHHHHHHCCCCC		18.9725720772
245PhosphorylationSQLRRLSSSLKCFDP
HHHHHHHHHCCCCCC		44.2625720772
246PhosphorylationQLRRLSSSLKCFDPE
HHHHHHHHCCCCCCC		28.5921712547
482PhosphorylationEMDITKNTTNSINNV
CEECCCCCCCCCCCC		28.9825720772
483PhosphorylationMDITKNTTNSINNVS
EECCCCCCCCCCCCH		36.0428889911
485PhosphorylationITKNTTNSINNVSQI
CCCCCCCCCCCCHHH		25.3025720772
490PhosphorylationTNSINNVSQISNGPF
CCCCCCCHHHCCCHH		24.7425720772
493PhosphorylationINNVSQISNGPFVER
CCCCHHHCCCHHHHH		28.2628889911
1059PhosphorylationNSDRSRLSDNELASF
CCCCCCCCHHHHHHH		36.9625720772
1292PhosphorylationEEEFEKDSEFLQHLD
HHHHHHHHHHHHHHH		41.1229996109
1304PhosphorylationHLDQNRGYSLTGTPT
HHHHCCCCCCCCCCC		9.4025720772
1305PhosphorylationLDQNRGYSLTGTPTY
HHHCCCCCCCCCCCC		23.4425720772
1307PhosphorylationQNRGYSLTGTPTYMA
HCCCCCCCCCCCCCC		32.8229996109
1309PhosphorylationRGYSLTGTPTYMAPE
CCCCCCCCCCCCCCH		13.7629996109
1311PhosphorylationYSLTGTPTYMAPELI
CCCCCCCCCCCCHHH		26.2629996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WIN1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WIN1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WIN1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WIS4_SCHPOwis4genetic
9450957
TEA4_SCHPOtea4physical
15936270
WIS1_SCHPOwis1physical
9693384
WIS1_SCHPOwis1genetic
9450957
BYR2_SCHPObyr2genetic
20729203
MKH1_SCHPOmkh1genetic
20729203
MCS4_SCHPOmcs4genetic
22661707
WIS4_SCHPOwis4genetic
22661707
WIS4_SCHPOwis4genetic
16087744
PYP1_SCHPOpyp1genetic
16087744
WIS4_SCHPOwis4genetic
22912829
PYP1_SCHPOpyp1genetic
22912829
WIS4_SCHPOwis4physical
23389634
MCS4_SCHPOmcs4physical
23389634
WIS1_SCHPOwis1genetic
1756736
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WIN1_SCHPO

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND THR-226, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory