| UniProt ID | MKH1_SCHPO | |
|---|---|---|
| UniProt AC | Q10407 | |
| Protein Name | MAP kinase kinase kinase mkh1 | |
| Gene Name | mkh1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 1116 | |
| Subcellular Localization | ||
| Protein Description | May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation.. | |
| Protein Sequence | MAADIGSQSSGSLEERFEQSLHLQNVDKQDWSLNSVLQFLKLYKFNKEWEDVFIKSRIEMDLFINLADQSKAEEFAFKNKLSKESAIQLSSCIRKTLLAPSSTRVPSKNSSYETLTYSAKDSSDDVFTETNSGFRSSNQNSSLKSFQSVPDSNVNVFGGFGGSVVDNNELLSTGKNSHQTTSLNLEGSPINLHAYKGTVTSIINDDSRNINKKTLSKQPVSEHKEKQTSFLRRFRVPGFSRDKDKTKDCPSSNSNPFHLASSNVKTLDASLDQGEWVPRIHRLESQIGLISKKKSFVLATMDDMKFTVVDITNVQNATQLRKLIAKSMYLDISIDQFDLFLTEVGGAQYIEILDDRKLDIARLYSDEFGTIKFFVKPSQNEESGMDSDTYLSFGTKSSSTYKADDDSIYHRKEDFKKQPSYPVLTSDFEITDAGPNLSLSGHQPDNKYYKGFSSAPNLAVVPELPSRRFRGFEKIRGAKGEMATKILDATEAQSEKNKFTVCRPHKKVTLKMPLNSGSSAPQSPSSNTSASVLTRNFVAHRDPPPPPTETSSLRRKNTLTRRPSIRHARSSPYIDTGHNEASKFSHTSFDPKASSKSSNSLKESVEALSEIPFEDAPALDESDLSGDPFWAIQPKQSSSQVPKENHHNIQSKLSINTEAATDLKANELSSPKTPEYCRGDDRSISLSPLSYRLRKSKHIRESPPSSKVINSGNWEVRPSADDLYEDVDRFFPRYDLDKVLVVDQSRMVSSPSKVSIRPKMKSVRLLAREASEARKEIRHNARRNKSGNLLRRSSTKLWGSRIVELKPDTTITSGSVVSQNATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFMKCDEEFNFKDTNLYDMLCKRKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | AADIGSQSSGSLEER CCCCCCCCCCCHHHH | 38.06 | 21712547 | |
| 12 | Phosphorylation | IGSQSSGSLEERFEQ CCCCCCCCHHHHHHH | 34.26 | 28889911 | |
| 20 | Phosphorylation | LEERFEQSLHLQNVD HHHHHHHHHHCCCCC | 15.57 | 21712547 | |
| 96 | Phosphorylation | LSSCIRKTLLAPSST HHHHHHHHHCCCCCC | 19.70 | 21712547 | |
| 101 | Phosphorylation | RKTLLAPSSTRVPSK HHHHCCCCCCCCCCC | 38.44 | 21712547 | |
| 102 | Phosphorylation | KTLLAPSSTRVPSKN HHHCCCCCCCCCCCC | 21.12 | 21712547 | |
| 103 | Phosphorylation | TLLAPSSTRVPSKNS HHCCCCCCCCCCCCC | 39.77 | 24763107 | |
| 107 | Phosphorylation | PSSTRVPSKNSSYET CCCCCCCCCCCCCEE | 41.43 | 24763107 | |
| 110 | Phosphorylation | TRVPSKNSSYETLTY CCCCCCCCCCEEEEE | 37.72 | 25720772 | |
| 111 | Phosphorylation | RVPSKNSSYETLTYS CCCCCCCCCEEEEEE | 36.06 | 29996109 | |
| 112 | Phosphorylation | VPSKNSSYETLTYSA CCCCCCCCEEEEEEE | 16.86 | 25720772 | |
| 122 | Phosphorylation | LTYSAKDSSDDVFTE EEEEECCCCCCCCCC | 34.65 | 25720772 | |
| 123 | Phosphorylation | TYSAKDSSDDVFTET EEEECCCCCCCCCCC | 48.22 | 25720772 | |
| 136 | Phosphorylation | ETNSGFRSSNQNSSL CCCCCCCCCCCCCCC | 31.23 | 21712547 | |
| 181 | Phosphorylation | GKNSHQTTSLNLEGS CCCCCCCCEEECCCC | 25.33 | 29996109 | |
| 182 | Phosphorylation | KNSHQTTSLNLEGSP CCCCCCCEEECCCCC | 20.74 | 25720772 | |
| 188 | Phosphorylation | TSLNLEGSPINLHAY CEEECCCCCEEEEEE | 17.15 | 24763107 | |
| 195 | Phosphorylation | SPINLHAYKGTVTSI CCEEEEEECCEEEEH | 10.13 | 21712547 | |
| 378 | Phosphorylation | IKFFVKPSQNEESGM EEEEECCCCCCCCCC | 39.66 | 21712547 | |
| 383 | Phosphorylation | KPSQNEESGMDSDTY CCCCCCCCCCCCCCE | 32.99 | 24763107 | |
| 387 | Phosphorylation | NEESGMDSDTYLSFG CCCCCCCCCCEEEEC | 23.98 | 24763107 | |
| 389 | Phosphorylation | ESGMDSDTYLSFGTK CCCCCCCCEEEECCC | 30.25 | 25720772 | |
| 392 | Phosphorylation | MDSDTYLSFGTKSSS CCCCCEEEECCCCCC | 15.94 | 21712547 | |
| 453 | Phosphorylation | NKYYKGFSSAPNLAV CCCCCCCCCCCCEEE | 33.97 | 25720772 | |
| 454 | Phosphorylation | KYYKGFSSAPNLAVV CCCCCCCCCCCEEEC | 45.55 | 25720772 | |
| 519 | Phosphorylation | MPLNSGSSAPQSPSS ECCCCCCCCCCCCCC | 47.71 | 25720772 | |
| 523 | Phosphorylation | SGSSAPQSPSSNTSA CCCCCCCCCCCCCCC | 26.20 | 29996109 | |
| 570 | Phosphorylation | PSIRHARSSPYIDTG CCHHHHHCCCCCCCC | 36.13 | 25720772 | |
| 571 | Phosphorylation | SIRHARSSPYIDTGH CHHHHHCCCCCCCCC | 19.03 | 29996109 | |
| 669 | Phosphorylation | DLKANELSSPKTPEY HCCCCCCCCCCCCHH | 38.11 | 29996109 | |
| 670 | Phosphorylation | LKANELSSPKTPEYC CCCCCCCCCCCCHHC | 42.94 | 29996109 | |
| 673 | Phosphorylation | NELSSPKTPEYCRGD CCCCCCCCCHHCCCC | 25.41 | 29996109 | |
| 683 | Phosphorylation | YCRGDDRSISLSPLS HCCCCCCCEECCHHH | 24.43 | 25720772 | |
| 685 | Phosphorylation | RGDDRSISLSPLSYR CCCCCCEECCHHHHH | 24.84 | 25720772 | |
| 687 | Phosphorylation | DDRSISLSPLSYRLR CCCCEECCHHHHHHH | 19.60 | 28889911 | |
| 690 | Phosphorylation | SISLSPLSYRLRKSK CEECCHHHHHHHHCC | 16.16 | 25720772 | |
| 702 | Phosphorylation | KSKHIRESPPSSKVI HCCCCCCCCCCCCCC | 32.06 | 28889911 | |
| 705 | Phosphorylation | HIRESPPSSKVINSG CCCCCCCCCCCCCCC | 46.29 | 29996109 | |
| 706 | Phosphorylation | IRESPPSSKVINSGN CCCCCCCCCCCCCCC | 36.39 | 29996109 | |
| 711 | Phosphorylation | PSSKVINSGNWEVRP CCCCCCCCCCCEECC | 23.52 | 29996109 | |
| 750 | Phosphorylation | DQSRMVSSPSKVSIR EHHHCCCCCCCCCCC | 23.06 | 21712547 | |
| 752 | Phosphorylation | SRMVSSPSKVSIRPK HHCCCCCCCCCCCCC | 47.87 | 24763107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MKH1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MKH1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MKH1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
