SPN3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPN3_SCHPO
• UniProt AC: P48008
• Protein Name: Septin homolog spn3
• Gene Name: spn3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 412
• Subcellular Localization: Cytoplasm, cell cortex . Localizes to the medial ring at the cell cortex of dividing cells.
• Protein Description: Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells..
• Protein Sequence: MWYTYNEDFGVVQLLFLHSNDTLTARTHITKGQIDIELTMRTTKKSSKKGIPLNLMVVGDVGLGRTAFINTLCEKPLIRHNNNFDPAEASSVSPVEIVPYQTDIILEDGTKINLTVLDTPHFGEAIDNENNFDIILQYIESQYDNVLEEESRIKRNARFCDDRVHALIYFISPTGHGLRELDIELMRRLAPRVNIIPAIAKADSLTAQELQTTKEMINADIEYYKIPVYDFPYDIEEDEEAIINLSQQLRATIPFAIVSSDRLIEMNGQTVRGRAYPWGVVEVDNPRHSDFLALRSALFATHIEDLHNITSNQLYETYRTEKLSTSQLLLDSTVGLDGKNLSQHDQVLREDRLRAIELSVQKEIEEKRRQLLAREEALRALEEKLAASTAAMANASVSTLPSSVSSTNHSQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
324	Phosphorylation	TYRTEKLSTSQLLLD HHHCCCCCHHHHHCC	36.76	25720772
325	Phosphorylation	YRTEKLSTSQLLLDS HHCCCCCHHHHHCCC	30.81	25720772
326	Phosphorylation	RTEKLSTSQLLLDST HCCCCCHHHHHCCCC	18.56	28889911
332	Phosphorylation	TSQLLLDSTVGLDGK HHHHHCCCCCCCCCC	25.59	25720772
342	Phosphorylation	GLDGKNLSQHDQVLR CCCCCCHHHHHHHHH	34.56	28889911
396	Phosphorylation	TAAMANASVSTLPSS HHHHHCCCHHHCCCC	19.19	25720772
398	Phosphorylation	AMANASVSTLPSSVS HHHCCCHHHCCCCCC	23.02	25720772
399	Phosphorylation	MANASVSTLPSSVSS HHCCCHHHCCCCCCC	40.30	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPN3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPN3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPN3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPN1_SCHPO	spn1	physical	15385632
SPN4_SCHPO	spn4	physical	15385632
SPN3_SCHPO	spn3	physical	15385632
SPT20_SCHPO	spt20	physical	25015293

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342, AND MASSSPECTROMETRY.
PubMed: 18257517