SPT20_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT20_SCHPO
• UniProt AC: O14174
• Protein Name: SAGA complex subunit spt20
• Gene Name: spt20
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 473
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs)..
• Protein Sequence: MERNNGLGDYTYRYHGKELSLDDFQNKQGIESSDDAFLSKIYENVSNFNVPRKLHDIEHKFSKEEPSLILHIHKFHFRFEQQDGAFTYNGPVKSILQYIRMELIPPDCLEVFRNSDVKFYDGCLTVRIIDHRQSPSADQTVQPQPGSTNQQQQNNTNPINNQPEDTKPNTNSPPVYHTVLRPTPETLWQDLCLLSESFANSLSDEAVLTLESNILLASEAPLFLTPAKSKAEMIQFMNQLADSAPPCTRKKPQGSAQLADEEAERLEKENLLLLMDDQRKRDFQPTFQRLQFIENVRRKRAILQQRQMQMQQQQKAQQQQSPKAQQPPAHLVQSAPVQRKTTPKIQRLPPSSIQIPPPKPMQKFPANAASSESPPNATGNFLPSGPVPANEPMLKRESVDLIKIRQLAILFQQRASQLKARGATREQITEILNRQAIAAGTDLATVMTVARNLHFQQLQMRQQQQQQQMKAER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
334	Phosphorylation	PPAHLVQSAPVQRKT CCHHHHCCCCCCCCC		21712547
342	Phosphorylation	APVQRKTTPKIQRLP CCCCCCCCCCCCCCC		27738172
370	Phosphorylation	KFPANAASSESPPNA CCCCCCCCCCCCCCC		27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT20_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT20_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT20_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPN2_SCHPO	spn2	physical	25015293
MID2_SCHPO	mid2	physical	25015293
MID2_SCHPO	mid2	genetic	25015293

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.