EIF3J_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3J_SCHPO
• UniProt AC: P87128
• Protein Name: Probable eukaryotic translation initiation factor 3 subunit J
• Gene Name: SPAC3A12.13c
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 274
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
• Protein Sequence: MDSWEDFLVEDPAKPAEFDFPLGKDSQSSSKPKKRFDDEEDEDEEENKESLQNDSHSVSQKSSSSSQNDQGSNKMTRIQQKIQERNFEKAIKASEAAAKEESLESSKEAMRQAEIDSDLANAMDLFDIVDKNSASANRSKQADQRQLKTKADYAAFQADILKKVKNCQTTAEYNNFVQDLIPLLLTGLNATNLKAVQKSVNKLVVNKEQQEKTQSKRGAAAPAAKPVSTAAPSKKGGKPTVNVNSKKTVADKSAYEDYIEDEYDDYADDFDDFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSWEDFLVE -----CCCHHHHCCC	30.94	21712547
50	Phosphorylation	DEEENKESLQNDSHS CHHHHHHHHHHCCCC	36.54	24763107
55	Phosphorylation	KESLQNDSHSVSQKS HHHHHHCCCCCHHHC	25.80	21712547
57	Phosphorylation	SLQNDSHSVSQKSSS HHHHCCCCCHHHCCC	27.67	21712547
59	Phosphorylation	QNDSHSVSQKSSSSS HHCCCCCHHHCCCCC	34.60	21712547
102	Phosphorylation	EAAAKEESLESSKEA HHHHHHHHHHHHHHH	38.23	21712547
105	Phosphorylation	AKEESLESSKEAMRQ HHHHHHHHHHHHHHH	52.59	25720772
106	Phosphorylation	KEESLESSKEAMRQA HHHHHHHHHHHHHHH	25.74	25720772
117	Phosphorylation	MRQAEIDSDLANAMD HHHHHHCHHHHHHHH	39.94	24763107
229	Phosphorylation	PAAKPVSTAAPSKKG CCCCCCCCCCCCCCC	27.37	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3J_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3J_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3J_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of EIF3J_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.