HOSM_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOSM_SCHPO
• UniProt AC: Q9Y823
• Protein Name: Homocitrate synthase, mitochondrial
• Gene Name: lys4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 418
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MSVSEANGTETIKPPMNGNPYGPNPSDFLSRVNNFSIIESTLREGEQFANAFFDTEKKIQIAKALDNFGVDYIELTSPVASEQSRQDCEAICKLGLKCKILTHIRCHMDDARVAVETGVDGVDVVIGTSQYLRKYSHGKDMTYIIDSATEVINFVKSKGIEVRFSSEDSFRSDLVDLLSLYKAVDKIGVNRVGIADTVGCATPRQVYDLIRTLRGVVSCDIECHFHNDTGMAIANAYCALEAGATHIDTSILGIGERNGITPLGALLARMYVTDREYITHKYKLNQLRELENLVADAVEVQIPFNNYITGMCAFTHKAGIHAKAILANPSTYEILKPEDFGMSRYVHVGSRLTGWNAIKSRAEQLNLHLTDAQAKELTVRIKKLADVRTLAMDDVDRVLREYHADLSDADRITKEASA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVSEANGT ------CCCCCCCCC	34.06	29996109
4	Phosphorylation	----MSVSEANGTET ----CCCCCCCCCCC	24.55	29996109
36	Phosphorylation	LSRVNNFSIIESTLR HHHHHCCCHHHHHHH	25.44	25720772
172	Phosphorylation	SSEDSFRSDLVDLLS CCCHHCCHHHHHHHH	33.03	25720772
179	Phosphorylation	SDLVDLLSLYKAVDK HHHHHHHHHHHHHHH	36.63	25720772
197	Phosphorylation	NRVGIADTVGCATPR CCCCCCCCCCCCCHH	15.13	29996109
202	Phosphorylation	ADTVGCATPRQVYDL CCCCCCCCHHHHHHH	24.07	28889911
330	Phosphorylation	KAILANPSTYEILKP EEEECCCCCCEECCH	43.35	25720772
353	Phosphorylation	VHVGSRLTGWNAIKS EEECHHHHCHHHHHH	38.75	28889911
360	Phosphorylation	TGWNAIKSRAEQLNL HCHHHHHHHHHHHCC	30.52	28889911
407	Phosphorylation	REYHADLSDADRITK HHHCCCCHHHHHHHH	31.16	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOSM_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOSM_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOSM_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOSM_SCHPO	lys4	physical	20089861
HOSM_SCHPO	lys4	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.