PTR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTR2_SCHPO
• UniProt AC: Q9P380
• Protein Name: Probable peptide transporter ptr2
• Gene Name: ptr2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 618
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Uptake of small peptides..
• Protein Sequence: MSSIEEQITKSDSDFIISEDQSYLSKEKKADGSATINTADEQSSTDELQKSMSTGVLVNGDLYPSPTEEELATLPRVCGTIPWKAFIIIIVELCERFAYYGLTVPFQNYMQFGPKDATPGALNLGESGADGLSNFFTFWCYVTPVGAALIADQFLGRYNTIVCSAVIYFIGILILTCTAIPSVIDAGKSMGGFVVSLIIIGLGTGGIKSNVSPLMAEQLPKIPPYVKTKKNGSKVIVDPVVTTSRAYMIFYWSINVGSLSVLATTSLESTKGFVYAYLLPLCVFVIPLIILAVSKRFYKHTPPSGSIFVRVGQVFFLAAQNKFNLEKTKPSCTTTVGRVTLKDQWDDLFIDELKRALRACKTFLFYPIYWVCYGQMTNNLISQAGQMQTGNVSNDLFQAFDSIALIIFIPICDNIIYPLLRKYNIPFKPILRITLGFMFATASMIYAAVLQAKIYQRGPCYANFTDTCVSNDISVWIQIPAYVLIAFSEIFASITGLEFAFTKAPPSMKSIITALFLFTNAFGAILSICISSTAVNPKLTWMYTGIAVTAFIAGIMFWVCFHHYDAMEDEQNQLEFKRNDALTKKDVEKEVHDSYSMADESQYNLEKATAEEEIMKST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSIEEQIT ------CCCHHHHHC	39.77	29996109
3	Phosphorylation	-----MSSIEEQITK -----CCCHHHHHCC	32.49	29996109
11	Phosphorylation	IEEQITKSDSDFIIS HHHHHCCCCCCEEEC	33.43	21712547
22	Phosphorylation	FIISEDQSYLSKEKK EEECCCHHHHCCCCC	40.12	28889911
23	Phosphorylation	IISEDQSYLSKEKKA EECCCHHHHCCCCCC	14.90	28889911
25	Phosphorylation	SEDQSYLSKEKKADG CCCHHHHCCCCCCCC	30.45	28889911
33	Phosphorylation	KEKKADGSATINTAD CCCCCCCCCCCCCCC	23.84	28889911
35	Phosphorylation	KKADGSATINTADEQ CCCCCCCCCCCCCCC	19.23	28889911
38	Phosphorylation	DGSATINTADEQSST CCCCCCCCCCCCCCH	31.47	21712547
43	Phosphorylation	INTADEQSSTDELQK CCCCCCCCCHHHHHH	32.91	25720772
44	Phosphorylation	NTADEQSSTDELQKS CCCCCCCCHHHHHHH	39.30	28889911
45	Phosphorylation	TADEQSSTDELQKSM CCCCCCCHHHHHHHH	38.45	28889911
51	Phosphorylation	STDELQKSMSTGVLV CHHHHHHHHHCCEEE	12.66	28889911
53	Phosphorylation	DELQKSMSTGVLVNG HHHHHHHHCCEEECC	29.15	28889911
54	Phosphorylation	ELQKSMSTGVLVNGD HHHHHHHCCEEECCC	23.75	28889911
594	Phosphorylation	VEKEVHDSYSMADES HHHHHHHHCCCCCHH	12.29	28889911
595	Phosphorylation	EKEVHDSYSMADESQ HHHHHHHCCCCCHHH	14.44	25720772
596	Phosphorylation	KEVHDSYSMADESQY HHHHHHCCCCCHHHH	16.08	29996109
601	Phosphorylation	SYSMADESQYNLEKA HCCCCCHHHHHHHHH	38.21	24763107
603	Phosphorylation	SMADESQYNLEKATA CCCCHHHHHHHHHHH	30.87	21712547
617	Phosphorylation	AEEEIMKST------ HHHHHHHCC------	23.20	27738172
618	Phosphorylation	EEEIMKST------- HHHHHHCC-------	36.79	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTR2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ISP4_SCHPO	isp4	genetic	22226946

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; TYR-23; SER-25;SER-33; THR-35; SER-44; THR-45; SER-51; SER-53; THR-54; SER-594 ANDTHR-618, AND MASS SPECTROMETRY.
PubMed: 18257517