ISP4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISP4_SCHPO
• UniProt AC: P40900
• Protein Name: Sexual differentiation process protein isp4
• Gene Name: isp4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 785
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Sequence: MIGSINESPIEEHMNDSPSTKEKADSVDISDYIVSHSDDSLSKDIKKDTKSFLDVEHGEISTVDEFEEDSPYPEVRAAVPPTDDPSMPCNTIRMWTIGLIYSTVGAAVNMFFSLRNPTVTLSVLISELLAYPALQIWDLIFPDREFRIGRLKFNFKPGPFNVKEHALIVVMSSVSFGNAYSTDIILAQRVHYKQRFGFGYEICLTLATQLIGYGLAGLSRRLLVRPASMLWPVNLVQCTLIKTLHRKDLRNAVANGWRISPFRFFLYVFIASFIWNWFPSYIFQALSLFAWVTWIRPNSPTVNQIFGESTGISILPMTFDWNQISAYILSPLMAPADALMNILLGVILFFWIVTPALNFTNTWYGDYLPISSSGIIDHFGNSYNVTRILTKDATFDLDAYQNYSPIFMSTTYALAFGLSFASITSVIFHVILYHGKEIYDRLRDPPAPDIHEKLMKAYDEVPFYWYLSVFLAFFGMMMGTIYGWKTETPWWVIIVGVIFSAVWFIPIGIVQAITNIQLGLNVFTEFIVGYMYPGRPLAMMIFKTVGYITMTQGLAFAADLKFGHYMKLPPRIMFYTQMIATIWSCFVQIGVLDWALGNIDNVCQADQPDNYTCPNATVFFNSSVIWGVIGPKRMFSGKNTYTGLQYFWLAGVLGTILFWALWKKWPQKWWGQLNGPLIFGGTGYIPPATPVNYLAWSGIGLFFNYYLKKIFADWWQKYNFTLSAALDTGTQLSVIILFFCLQLPMVNFPDWWGNDGAFNTLDATGAAVRKLVNESAGEFFGPAEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MIGSINESPIE ----CCCCCCCCCCH	16.00	21712547
8	Phosphorylation	MIGSINESPIEEHMN CCCCCCCCCCHHHCC	27.04	24763107
17	Phosphorylation	IEEHMNDSPSTKEKA CHHHCCCCCCHHHHC	18.75	21712547
19	Phosphorylation	EHMNDSPSTKEKADS HHCCCCCCHHHHCCC	56.94	21712547
26	Phosphorylation	STKEKADSVDISDYI CHHHHCCCCCHHHHH	26.92	24763107
30	Phosphorylation	KADSVDISDYIVSHS HCCCCCHHHHHHHCC	21.65	24763107
32	Phosphorylation	DSVDISDYIVSHSDD CCCCHHHHHHHCCCC	9.09	21712547
35	Phosphorylation	DISDYIVSHSDDSLS CHHHHHHHCCCCCCC	14.02	21712547
37	Phosphorylation	SDYIVSHSDDSLSKD HHHHHHCCCCCCCHH	35.29	21712547
40	Phosphorylation	IVSHSDDSLSKDIKK HHHCCCCCCCHHHHH	39.26	21712547
42	Phosphorylation	SHSDDSLSKDIKKDT HCCCCCCCHHHHHHC	32.03	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISP4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISP4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISP4_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of ISP4_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.