dbPTM

VAC14_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VAC14_SCHPO
UniProt AC	P87145
Protein Name	Protein VAC14 homolog
Gene Name	SPBC25H2.03
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	811
Subcellular Localization	Cytoplasm. Vacuole membrane Peripheral membrane protein.
Protein Description	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization (By similarity)..
Protein Sequence	MDNLLVRGLTHKLYDKRKATAYELERVVKGYLENDETEKIRAVISQLANDFVYSPARGPNATFGGLIGLAAVAIALGPKIDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFRYFNLIFDVLCKLFADTEITVKNGAELLDRLIKDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFISYLPFLLDGLMNYLSDPNESIRIVTSNCLYDFLREIQKIAKVKYHILQRDEESEPDFFDSMVRRNMSDAELKEISDYVESSLRDGSFILEAHIQIDYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKDVLLQIPKVLENLLPLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGGKLINMHDPIFQTLLLQLSDPSDLVVSRTLELLAHIAISHKSVNLVPFLKSLLQMFAEDRKFLNSRGNLIIRQLCNYIEGERVYTSFAGILETEENLELASIMVEVLNNNLFTAPELYDLRKKLKQSAPKLQNIFTTLYTAWCHNSIAVFSLCLLSQNYEHAANLLSVFAEIEFNIDMLIQLDKLVQLIESPVFTYMRLQLLEPEKYPYLHKALYGILMLLPQSSAFRTLRDRLQCSSTPRTNTILANERLPRSRRDDPYWTDLLERLKAVQLSHQNNYREPIRATRLALAGALPSTPTATTISTTTSASGITTTASNSRDSFITRLPPTAALSTGARKKPKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
181	Phosphorylation	NFKEGPVSSSIQDVP HCCCCCCCCCCCCCC	22.85	29996109
183	Phosphorylation	KEGPVSSSIQDVPVM CCCCCCCCCCCCCCC	19.43	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VAC14_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VAC14_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VAC14_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
POF10_SCHPO	pof10	genetic	18931302

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VAC14_SCHPO

Related Literatures of Post-Translational Modification