dbPTM

CAT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAT1_SCHPO
UniProt AC	Q9URZ4
Protein Name	Cationic amino acid transporter 1
Gene Name	cat1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	587
Subcellular Localization	Cell membrane Multi-pass membrane protein . Cell tip . enriched toward the growing ends of the cells.
Protein Description	Major permease specifically involved in arginine and lysine uptake..
Protein Sequence	MSHSDFNMEPEYVSFSDKDTKSILNESKSSLKDVKPSLEEKSYITPGLVDDVEPKGKNFVVRFFDDFKPAKATGEDGTALKRSLKSRHMQMISIGGAIGTGLYVGSGSSLADGGPASVIINYSLIGIMMFFIVYALGEMAVAYPVAGGFNTYATRFIDPAWGFAVSWNYFINYFVTFPLELTTCAITFRYWTDINSAAWISIFLVVIIIVNLFGVRAYGEVEFILSTVKVVATFGFIILAIIINCGGVPTDHRGYIGGSIIKHKPFRHGFKGFCSVFTTAAFSFSGTEVIGLAAAEVDNPQKALPHAVKQVFWRIAIFYVVSLILIGLLISPDDPNLMGNGSTSVSPFVLAIKEANIKGLPSVFNAVIIISVVSVTNSSTYTAGRTLHGMANLKQAPSFFKYTDRLGRPLLAMIVVLLFGFFAYINEADKNGNDVSDTVFNWLLALSGLSNFFTWGSICLCHIIFRLAFKKQGHSLKELGFVSPMGIWGSCIGLFFNILCLMAQFYVSLFPIGGKPNANDFFQGYLAAPVTLAFFIGYKIYDRSHIPSLDKLDITTGLKTYENLDEEEDEPTTASKRIFKKISSVFC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHSDFNME ------CCCCCCCCC	31.53	29996109
4	Phosphorylation	----MSHSDFNMEPE ----CCCCCCCCCCC	36.27	29996109
14	Phosphorylation	NMEPEYVSFSDKDTK CCCCCCCCCCCHHHH	20.38	29996109
16	Phosphorylation	EPEYVSFSDKDTKSI CCCCCCCCCHHHHHH	35.92	29996109
20	Phosphorylation	VSFSDKDTKSILNES CCCCCHHHHHHHHHC	32.22	29996109
22	Phosphorylation	FSDKDTKSILNESKS CCCHHHHHHHHHCHH	34.11	24763107
27	Phosphorylation	TKSILNESKSSLKDV HHHHHHHCHHHHCCC	36.44	21712547
29	Phosphorylation	SILNESKSSLKDVKP HHHHHCHHHHCCCCC	50.62	28889911
30	Phosphorylation	ILNESKSSLKDVKPS HHHHCHHHHCCCCCC	43.08	28889911
37	Phosphorylation	SLKDVKPSLEEKSYI HHCCCCCCHHHHCCC	42.57	28889911
42	Phosphorylation	KPSLEEKSYITPGLV CCCHHHHCCCCCCCC	25.66	24763107
43	Phosphorylation	PSLEEKSYITPGLVD CCHHHHCCCCCCCCC	21.63	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CAT1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CAT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAT1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CAT1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAT1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-30 AND SER-37,AND MASS SPECTROMETRY.	18257517 [Abstract]