TRK1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRK1_SCHPO
• UniProt AC: P47946
• Protein Name: Potassium transport protein 1
• Gene Name: trk1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 841
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Together with TRK2, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential..
• Protein Sequence: MVLNYIQRWFKWVIPTFGFLAIHYIYIISLTIIASILLFTGGTTTKIKYIDALFLASSATTQTGLNSVDLNSLSIWQQFILYGFTAITVPIWMHGSISFIRLYWFRRKFKDVVRQNRTRKFQRKLRKSLMKKSEDDEEQGVRGRKIRVMLPYLHSLRSPTSLKNFSRFDTHDSTNNPYFPDNPPSPKADISKDEYFGKYLPKKSDTLDMDLESHNMTFHDYEPSIENKNYDFGSSHSASMQMYEMDDLHPRLRRQSSFISSVNPLEADDTRETLSEGALVQESLPMAYSYSDTNLVVSRDSFTLTGDDNLFPEGGLRPANTIDGIVRSSLSSSSLSKDTEPSTVDMHIAFTGLNKPTIERERNLKLRKKSRFYKKSLRSRFSRGLHRPIRWTKSFTSNRRNLTLERVLSSAFAKKREPSISSRHTTMSLPYLSYNPTVDRNSAFVALSKEQRDELGGIEYRALKCVCSMVTLYFIIFNIAAFVTFIVFAYTAVGSREVIDSYDLRRGWWALFSSASSFNDLGFSLIPSSFVPMNRNIFLLLISSLFIIAGNTGFPCFFRTFIWTTYKLYPFSFEKKEAMAFLLDHPRRCFTLLFPSGATWVLFFVLLLLNVIDLVLFMVLDTGSKAVASLPKGIRVVNAIFQSVCTRTAGFTSVSISELHPAVLVSYMVMMYISVYPVAINMRNTNVYEERSLGVYRTEDDEGKSFLKDHLTEQLSYDLWYIFLGLFIICICEGGKISNPLDTDFSIFTVLFEVVSAYGTVGLSTGLSSSNCSLSARFTTISKLVIIALELRGRHRGLPRAVDRAILLPSEKNNLKEEEDYQRRHGFSIDNARGSIAVSRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	N-linked_Glycosylation	FKDVVRQNRTRKFQR HHHHHHHHHHHHHHH	36.40	-
160	Phosphorylation	LHSLRSPTSLKNFSR HHHCCCCCCCCCCCC	48.19	25720772
161	Phosphorylation	HSLRSPTSLKNFSRF HHCCCCCCCCCCCCC	40.50	25720772
164	N-linked_Glycosylation	RSPTSLKNFSRFDTH CCCCCCCCCCCCCCC	45.48	-
166	Phosphorylation	PTSLKNFSRFDTHDS CCCCCCCCCCCCCCC	41.24	21712547
170	Phosphorylation	KNFSRFDTHDSTNNP CCCCCCCCCCCCCCC	25.52	25720772
174	Phosphorylation	RFDTHDSTNNPYFPD CCCCCCCCCCCCCCC	45.10	21712547
185	Phosphorylation	YFPDNPPSPKADISK CCCCCCCCCCCCCCC	40.05	24763107
215	N-linked_Glycosylation	DMDLESHNMTFHDYE CCCHHHCCCCCCCCC	40.23	-
401	N-linked_Glycosylation	SFTSNRRNLTLERVL CCCCCCCCCCHHHHH	33.85	-
409	Phosphorylation	LTLERVLSSAFAKKR CCHHHHHHHHHHHHC	19.43	25720772
410	Phosphorylation	TLERVLSSAFAKKRE CHHHHHHHHHHHHCC	24.20	25720772
426	Phosphorylation	SISSRHTTMSLPYLS CCCCCCCCCCCCCCC	9.91	25720772
428	Phosphorylation	SSRHTTMSLPYLSYN CCCCCCCCCCCCCCC	24.89	25720772
771	N-linked_Glycosylation	STGLSSSNCSLSARF CCCCCCCCCCCCEEE	22.73	-
828	Phosphorylation	YQRRHGFSIDNARGS HHHHHCCCCCCCCCC	33.36	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRK1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRK1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRK1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAH_SCHPO	sod2	genetic	10091581
PPZ_SCHPO	pzh1	genetic	10091581

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.