NAH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAH_SCHPO
• UniProt AC: P36606
• Protein Name: Na(+)/H(+) antiporter
• Gene Name: sod2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 468
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Sodium export from cell, takes up external protons in exchange for internal sodium ions. Involved in regulation of pH..
• Protein Sequence: MGWRQLDIDKVHLALIVAGGFITFFCYFSEVFRKKLLVGEAVLGSITGLIFGPHAAKLVDPFSWGDHGDYLTVEICRIVLDVRVFASAIELPGAYFQHNFRSIIVMLLPVMAYGWLVTAGFAYALFPQINFLGSLLIAGCITSTDPVLSALIVGEGPLAKKTPERIRSLLIAESGCNDGMAVPFFYFAIKLLTVKPSRNAGRDWVLLVVLYECAFGIFFGCVIGYLLSFILKHAQKYRLIDAISYYSLPLAIPLLCSGIGTIIGVDDLLMSFFAGILFNWNDLFSKNISACSVPAFIDQTFSLLFFTYYGTIIPWNNFNWSVEGLPVWRLIVFSILTLVCRRLPVVFSVKPLVPDIKTWKEALFVGHFGPIGVCAVYMAFLAKLLLSPDEIEKSIYESTTVFSTLNEIIWPIISFVILSSIIVHGFSIHVLVIWGKLKSLYLNRKVTKSDSDLELQVIGVDKSQEDYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
287	N-linked_Glycosylation	WNDLFSKNISACSVP CHHHHCCCCCCCCHH	32.05	-
319	N-linked_Glycosylation	IIPWNNFNWSVEGLP EEECCCCCCCCCCCC	32.03	-
447	Phosphorylation	LYLNRKVTKSDSDLE HHHCCCCCCCCCCCE	28.06	21712547
449	Phosphorylation	LNRKVTKSDSDLELQ HCCCCCCCCCCCEEE	32.74	28889911
451	Phosphorylation	RKVTKSDSDLELQVI CCCCCCCCCCEEEEE	51.70	28889911
463	Phosphorylation	QVIGVDKSQEDYV-- EEEEECCCCCCCC--	34.05	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAH_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUB1_SCHPO	pub1	genetic	9197411
PPZ_SCHPO	pzh1	genetic	9428701
NAH_SCHPO	sod2	physical	18629612

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449 AND SER-451, ANDMASS SPECTROMETRY.
PubMed: 18257517