SPM1_SCHPO - dbPTM
SPM1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPM1_SCHPO
UniProt AC Q92398
Protein Name Mitogen-activated protein kinase spm1
Gene Name spm1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 422
Subcellular Localization
Protein Description Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions..
Protein Sequence MDRRHRVYRVFNQEMYVEPNFKVVKELGQGAYGIVCAARNVASKDQEAVAIKKITNVFSKSILTKRALREIKLLIHFRNHRNITCIYDLDIINPYNFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLARGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDEETLSHISSSRAQEYVRSLPKQRPIPFETNFPKANPLALDLLAKLLAFDPNRRISVDDALEHPYLAVWHDPSDEPVCDSVFDFSFEYIEDANELRRVILDEVLNFRQKVRRRSHPTNPTVNIPQPAQTVPSNDNGSFNVSSSSSSQTSNKKRHDHSYNETAAIDHKSDDNRHN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
175PhosphorylationFGLARGCSENPEENP
HHCCCCCCCCCCCCC		43.1429996109
186PhosphorylationEENPGFMTEYVATRW
CCCCCHHHHHHHHCE		23.1528889911
188PhosphorylationNPGFMTEYVATRWYR
CCCHHHHHHHHCEEC		6.0428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPM1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPM1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPM1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCK1_SCHPOpck1genetic
17005909
MKH1_SCHPOmkh1physical
16291757
SKH1_SCHPOpek1physical
16291757
RNC1_SCHPOrnc1physical
12931193
PCK2_SCHPOpck2genetic
8943330
PCK1_SCHPOpck1genetic
8943330
ATF1_SCHPOatf1physical
17881729
YBKD_SCHPOgmh6genetic
19547744
YOP2_SCHPOSPBC418.02genetic
19547744
KIN1_SCHPOkin1genetic
20624220
H2AZ_SCHPOpht1genetic
18818364
PAB2_SCHPOpab2genetic
18818364
ELP5_SCHPOelp5genetic
18818364
COPE_SCHPOsec28genetic
18818364
NGG1_SCHPOngg1genetic
18818364
PTEN_SCHPOptn1genetic
18818364
POB3_SCHPOpob3genetic
18818364
ELP4_SCHPOelp4genetic
18818364
PEF1_SCHPOpef1genetic
18818364
CAF1_SCHPOcaf1genetic
18818364
BMT5_SCHPOSPCC1919.13cgenetic
18818364
NOT2_SCHPOnot2genetic
18818364
AMO1_SCHPOamo1genetic
18818364
FBH1_SCHPOfbh1genetic
18818364
ERS1_SCHPOers1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
PPK35_SCHPOmug27genetic
18818364
AGO1_SCHPOago1genetic
18818364
CDK1_SCHPOcdc2genetic
22918952
FLP1_SCHPOclp1physical
22918952
RIK1_SCHPOrik1genetic
22681890
DHE4_SCHPOgdh1genetic
22681890
TPP1_SCHPOtpp1genetic
22681890
RYH1_SCHPOryh1genetic
22681890
IDHP_SCHPOidp1genetic
22681890
YD83_SCHPOSPAC1F3.03genetic
22681890
PCK1_SCHPOpck1genetic
22681890
SWI6_SCHPOswi6genetic
22681890
PPK14_SCHPOppk14genetic
22681890
MCA1_SCHPOpca1genetic
22681890
RAF2_SCHPOraf2genetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
SPN3_SCHPOspn3genetic
22681890
YEM8_SCHPOclr5genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
VPS1_SCHPOvps1genetic
22681890
APT_SCHPOapt1genetic
22681890
YAC5_SCHPOcph1genetic
22681890
UFD2_SCHPOufd2genetic
22681890
YF48_SCHPOSPAC3H5.08cgenetic
22681890
MUG33_SCHPOmug33genetic
22681890
YGRG_SCHPOSPBC365.16genetic
22681890
CHP1_SCHPOchp1genetic
22681890
YC1B_SCHPOmsy1genetic
22681890
YGWH_SCHPOgmh4genetic
22681890
SWD1_SCHPOswd1genetic
22681890
HOB3_SCHPOhob3genetic
22681890
MUG80_SCHPOmug80genetic
22681890
POM1_SCHPOpom1genetic
22681890
FT105_SCHPOftp105genetic
22681890
DSC4_SCHPOdsc4genetic
22681890
PNK1_SCHPOpnk1genetic
22681890
RL43B_SCHPOrpl4302genetic
22681890
GBB_SCHPOgit5genetic
22681890
GPA2_SCHPOgpa2genetic
22681890
VPS38_SCHPOvps38genetic
22681890
YEEB_SCHPOSPAC19A8.11cgenetic
22681890
JHD1_SCHPOepe1genetic
22681890
YNW5_SCHPOyar1genetic
22681890
AATM_SCHPOSPBC725.01genetic
22681890
RAF1_SCHPOraf1genetic
22681890
YOW5_SCHPOSPBC1861.05genetic
22681890
MST2_SCHPOmst2genetic
22681890
BCS1_SCHPOSPAC644.07genetic
22681890
SET1_SCHPOset1genetic
22681890
GMA12_SCHPOgma12genetic
22681890
YAM5_SCHPOmso1genetic
22681890
PPK6_SCHPOppk6genetic
22681890
KPR1_SCHPOSPAC4A8.14genetic
22681890
YQMA_SCHPOSPCP1E11.10genetic
22681890
MPC1_SCHPOmpc1genetic
22681890
YFE6_SCHPOgmh5genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
PGM3_SCHPOSPCC1840.05cgenetic
22681890
TCG1_SCHPOtcg1genetic
22681890
PP2B_SCHPOppb1genetic
23738021
RHO1_SCHPOrho1genetic
24498240
SKH1_SCHPOpek1physical
26432170
RHO4_SCHPOrho4genetic
25651781
RHO5_SCHPOrho5genetic
25651781
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPM1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186 AND TYR-188, ANDMASS SPECTROMETRY.

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