PPK6_SCHPO - dbPTM
PPK6_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPK6_SCHPO
UniProt AC Q9UTH3
Protein Name Serine/threonine-protein kinase ppk6
Gene Name ppk6
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 775
Subcellular Localization Cytoplasm . Nucleus .
Protein Description
Protein Sequence MSQDVFKHLTSKQVQRTRARSFGASFERPLASFLPKKENKNLLSNAARVKLLTFSSSSPYSFSYSPVLSRDANDGYIPLDTSSRANLWESVTDYDLQHANEPLVGNYYISTEALGDGLNRSPFTINPEKRRSLSDISYVPIPHKEHSNWPVHCSSQAIVTTSNTTFSIWSANDYFCLLFGYAGSQLNRHSVFDIFPKSFSSHLSNLIVSFPIDNEHERILFCGDVFPVITVDGVRLMDFWVKEKQGKLIWILEFVEESYIDIKLQDGVAVDERTEQPLTSDLLPSRLPKTWDQRLYLTTKTTEGYYCPSMIYPLSKSSFQYIIFHYAAGLLFINSDFKIISLNEALFESMLGYSDLLTKDISLIFPDFKLVLQQLADSHALDPGRVVSEIHVRHAYRTCTADKMKKADYPYLIHSDGNIIQIDCQIISVSPHSVKSNEPAFGVWLIFDSVDNRASDFVRSMRSSVILEEVVISDESEEEEDLSADEDYVDSEWEVVPHNIASYTTIKELGIGAYGQVKLATYKSNKVHEVILKSISKSRILLDSWMRDKDLGTVPMEISILHFLKAHSHPNIVKMITFFEDNENYYLLTEPQKPGIDLFDYIELKPSISEKESKAIFFQIALAVAHLHSFDIIHRDIKDENVILEGNGCARLIDFGSSSLTKNGPFDTFRGTVGFAAPELLRGEKYLGKEQDIWALGILLYTIVYRENPYYNIEEILDAKLRIPFELSKDNVDLICRMLDRNVHDRITIEETLQHHWFDDIRYLDTSHIRIPLSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationVQRTRARSFGASFER
HHHHHHHHHCCCCCC		27.3529996109
25PhosphorylationRARSFGASFERPLAS
HHHHHCCCCCCCHHH		28.1929996109
32PhosphorylationSFERPLASFLPKKEN
CCCCCHHHHCCHHHC		34.6929996109
132PhosphorylationINPEKRRSLSDISYV
CCHHHCCCCCCCEEE		35.9428889911
134PhosphorylationPEKRRSLSDISYVPI
HHHCCCCCCCEEEEC		33.8628889911
137PhosphorylationRRSLSDISYVPIPHK
CCCCCCCEEEECCCC		25.6824763107
138PhosphorylationRSLSDISYVPIPHKE
CCCCCCEEEECCCCC		15.5825720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPK6_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPK6_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPK6_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PPK14_SCHPOppk14genetic
22681890
LUB1_SCHPOlub1genetic
22681890
YE99_SCHPOglc9genetic
22681890
PNPP_SCHPOpho2genetic
22681890
SPP1_SCHPOspf1genetic
22681890
ULP2_SCHPOulp2genetic
22681890
YE08_SCHPOSPAC17H9.08genetic
22681890
GIT3_SCHPOgit3genetic
22681890
ASH2_SCHPOash2genetic
22681890
GBB_SCHPOgit5genetic
22681890
HUS1_SCHPOhus1genetic
22681890
SET1_SCHPOset1genetic
22681890
SPM1_SCHPOpmk1genetic
22681890
UGPA1_SCHPOfyu1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPK6_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-134, ANDMASS SPECTROMETRY.

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