dbPTM

HUS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HUS1_SCHPO
UniProt AC	P78955
Protein Name	Checkpoint protein hus1
Gene Name	hus1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	287
Subcellular Localization	Cytoplasm . Nucleus, nucleolus . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body .
Protein Description	Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage..
Protein Sequence	MRFKTRISNLYTLTRLVQALDKIGRFCWLRLMPETVNFVIVPDFRMTQVWSVLEVETIFEDYVVQSNADNVINLEVPIDNFYKALRSAANASDSTVRLSKKNNQPLLSLSTTWSGRAFGSNIVTHNIPVRVLSQSYVSVIKEPTAPEPDCHIFLPQLNFLRHVVDKYKSLSDRIIMSANMSGELQLSVNIPSARVSTKWKGLENPELDPSQVEDISRHPSQTRAPEEFVHMRLDSKDLVNMLKISSVAKRVIACFCEGHALVLYVYITDPEDEHTAVLTYYISTYVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
210	Phosphorylation	ENPELDPSQVEDISR CCCCCCHHHHHHHHH	46.67	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HUS1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HUS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HUS1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD26_SCHPO	rad26	genetic	12196391
RAD3_SCHPO	rad3	genetic	12196391
TAZ1_SCHPO	taz1	genetic	12196391
RAD1_SCHPO	rad1	genetic	9524127
RAD1_SCHPO	rad1	physical	9524127
MYH1_SCHPO	myh1	physical	15533944
APE1_SCHPO	ape2	physical	17426133
DDB1_SCHPO	ddb1	genetic	18931302
MYH1_SCHPO	myh1	physical	20816984
RAD9_SCHPO	rad9	physical	21095590
RAD57_SCHPO	rad57	genetic	18818364
HRQ1_SCHPO	hrq1	genetic	18818364
YEG3_SCHPO	pcf2	genetic	18818364
NTH_SCHPO	nth1	genetic	18818364
FEN1_SCHPO	rad2	genetic	18818364
MRC1_SCHPO	mrc1	genetic	18818364
TRM10_SCHPO	trm10	genetic	18818364
MPH1_SCHPO	fml1	genetic	18818364
MCL1_SCHPO	mcl1	genetic	18818364
CSN1_SCHPO	csn1	genetic	18818364
EXO1_SCHPO	exo1	genetic	18818364
SWI3_SCHPO	swi3	genetic	18818364
RT109_SCHPO	rtt109	genetic	18818364
YO48_SCHPO	SPBC36B7.08c	genetic	18818364
APN2_SCHPO	apn2	genetic	18818364
RAD14_SCHPO	rhp14	genetic	18818364
ATM_SCHPO	tel1	genetic	18818364
CCR4_SCHPO	ccr4	genetic	18818364
RAD7_SCHPO	rhp7	genetic	18818364
MU154_SCHPO	mug154	genetic	18818364
POM1_SCHPO	pom1	genetic	18818364
SNF5_SCHPO	snf5	genetic	18818364
URK1_SCHPO	SPCC162.11c	genetic	18818364
RHP9_SCHPO	crb2	genetic	12839619
PEX1_SCHPO	pex1	genetic	22681890
MDE5_SCHPO	mde5	genetic	22681890
YELB_SCHPO	SPAC6F6.11c	genetic	22681890
SIP5_SCHPO	SPBC25B2.03	genetic	22681890
HS104_SCHPO	hsp104	genetic	22681890
AMY4_SCHPO	meu7	genetic	22681890
UBLH2_SCHPO	uch2	genetic	22681890
PDP2_SCHPO	SPBC215.07c	genetic	22681890
GLO22_SCHPO	SPCC13B11.03c	genetic	22681890
ALG12_SCHPO	alg12	genetic	22681890
EXG3_SCHPO	exg3	genetic	22681890
RAD13_SCHPO	rad13	genetic	22681890
FEN1_SCHPO	rad2	genetic	22681890
UPP2_SCHPO	SPAC1399.04c	genetic	22681890
YEG3_SCHPO	pcf2	genetic	22681890
YA33_SCHPO	SPAC18B11.03c	genetic	22681890
YH51_SCHPO	SPBC215.01	genetic	22681890
YCX5_SCHPO	dbl1	genetic	22681890
AP2S_SCHPO	aps2	genetic	22681890
ATP10_SCHPO	atp10	genetic	22681890
SHE9_SCHPO	SPAC823.13c	genetic	22681890
YD53_SCHPO	SPAC6C3.03c	genetic	22681890
UPP3_SCHPO	urg2	genetic	22681890
RT109_SCHPO	rtt109	genetic	22681890
PIMT_SCHPO	pcm2	genetic	22681890
EFTS_SCHPO	tsf1	genetic	22681890
LCMT1_SCHPO	ppm1	genetic	22681890
FRP2_SCHPO	frp2	genetic	22681890
ATCX_SCHPO	SPAC24B11.12c	genetic	22681890
RAD55_SCHPO	rad55	genetic	22681890
PLB2_SCHPO	SPAC1A6.03c	genetic	22681890
TIM21_SCHPO	tim21	genetic	22681890
EXO70_SCHPO	exo70	genetic	22681890
SDH3_SCHPO	sdh3	genetic	22681890
TRM10_SCHPO	trm10	genetic	22681890
FMP32_SCHPO	SPAC2C4.09	genetic	22681890
YHS6_SCHPO	SPBC947.06c	genetic	22681890
IF4E2_SCHPO	tif452	genetic	22681890
SNF5_SCHPO	snf5	genetic	22681890
YAN8_SCHPO	SPAC3H1.08c	genetic	22681890
YN25_SCHPO	prt1	genetic	22681890
GIT3_SCHPO	git3	genetic	22681890
EXO1_SCHPO	exo1	genetic	22681890
DCTD_SCHPO	dcd1	genetic	22681890
MAL3_SCHPO	mal3	genetic	22681890
YBD4_SCHPO	dbl6	genetic	22681890
YAOF_SCHPO	SPAC11D3.15	genetic	22681890
MEU10_SCHPO	meu10	genetic	22681890
YCD2_SCHPO	pxd1	genetic	22681890
NTH_SCHPO	nth1	genetic	22681890
PPK30_SCHPO	ppk30	genetic	22681890
ARP42_SCHPO	arp42	genetic	22681890
CAO2_SCHPO	cao2	genetic	22681890
RTN1_SCHPO	rtn1	genetic	22681890
YGB8_SCHPO	SPBC25B2.08	genetic	22681890
RAD57_SCHPO	rad57	genetic	22681890
SUMT_SCHPO	SPCC1739.06c	genetic	22681890
FSV1_SCHPO	fsv1	genetic	22681890
BRO1_SCHPO	bro1	genetic	22681890
TPSX_SCHPO	SPACUNK4.16c	genetic	22681890
NTO1_SCHPO	nto1	genetic	22681890
ANM3_SCHPO	rmt3	genetic	22681890
YB22_SCHPO	SPBC31F10.02	genetic	22681890
SOL1_SCHPO	sol1	genetic	22681890
PEX6_SCHPO	pex6	genetic	22681890
MU183_SCHPO	mug183	genetic	22681890
COQ10_SCHPO	coq10	genetic	22681890
PP2C3_SCHPO	ptc3	genetic	22681890
PEX5_SCHPO	pex5	genetic	22681890
YFM8_SCHPO	SPAC222.08c	genetic	22681890
YO48_SCHPO	SPBC36B7.08c	genetic	22681890
YF07_SCHPO	SPAC56E4.07	genetic	22681890
FRP1_SCHPO	frp1	genetic	22681890
BYR3_SCHPO	byr3	genetic	22681890
ATC2_SCHPO	SPAPB2B4.04c	genetic	22681890
FKBP4_SCHPO	fkbp39	genetic	22681890
HMT1_SCHPO	hmt1	genetic	22681890
PDS5_SCHPO	pds5	genetic	22681890
ATP11_SCHPO	atp11	genetic	22681890
MU172_SCHPO	msd1	genetic	22681890
PTF2_SCHPO	ptf2	genetic	22681890
MUG96_SCHPO	mug96	genetic	22681890
YL39_SCHPO	SPAC1071.09c	genetic	22681890
PLPL_SCHPO	ptl2	genetic	22681890
PIT1_SCHPO	pit1	genetic	22681890
RL16B_SCHPO	rpl1601	genetic	22681890
YBAC_SCHPO	rud3	genetic	22681890
RTI1_SCHPO	rti1	genetic	22681890
YC82_SCHPO	SPCC622.02	genetic	22681890
NMT1_SCHPO	nmt1	genetic	22681890
ALM1_SCHPO	alm1	genetic	22681890
SGT2_SCHPO	SPAC1142.02c	genetic	22681890
PPK38_SCHPO	ppk38	genetic	22681890
TOM70_SCHPO	tom70	genetic	22681890
BUT2_SCHPO	but2	genetic	22681890
YI47_SCHPO	SPBC1348.07	genetic	22681890
YI75_SCHPO	SPAC977.05c	genetic	22681890
SAT1_SCHPO	sat1	genetic	22681890
SPEB2_SCHPO	SPBC8E4.03	genetic	22681890
YBE8_SCHPO	SPBC17D11.08	genetic	22681890
YOFG_SCHPO	SPBP4H10.16c	genetic	22681890
ALAT_SCHPO	SPBC582.08	genetic	22681890
YB0A_SCHPO	SPBC25H2.10c	genetic	22681890
VPS27_SCHPO	sst4	genetic	22681890
YCPE_SCHPO	trp663	genetic	22681890
SIF3_SCHPO	sif3	genetic	22681890
YDT4_SCHPO	SPAC6B12.04c	genetic	22681890
VMS1_SCHPO	vms1	genetic	22681890
YDL6_SCHPO	SPAC3A12.06c	genetic	22681890
SND1_SCHPO	snd1	genetic	22681890
TREA_SCHPO	ntp1	genetic	22681890
PDE1_SCHPO	cgs2	genetic	22681890
RHO4_SCHPO	rho4	genetic	22681890
PPK6_SCHPO	ppk6	genetic	22681890
YGW2_SCHPO	vps68	genetic	22681890
VAC14_SCHPO	SPBC25H2.03	genetic	22681890
WTF15_SCHPO	wtf15	genetic	22681890
CTU2_SCHPO	ctu2	genetic	22681890
KPR1_SCHPO	SPAC4A8.14	genetic	22681890
MOK11_SCHPO	mok11	genetic	22681890
YOM1_SCHPO	SPBPB7E8.01	genetic	22681890
YC8E_SCHPO	SPCC622.14	genetic	22681890
MCL1_SCHPO	mcl1	genetic	22681890
PGC1_SCHPO	SPAC4D7.02c	genetic	22681890
RHP23_SCHPO	rhp23	genetic	22681890
BGLS_SCHPO	SPBC1683.04	genetic	22681890
PPK29_SCHPO	ppk29	genetic	22681890
YOX1_SCHPO	yox1	genetic	22681890
MET8_SCHPO	SPAC4D7.06c	genetic	22681890
YI43_SCHPO	SPBC1348.03	genetic	22681890
BGS4_SCHPO	bgs4	genetic	22681890
YNK4_SCHPO	SPBC29B5.04c	genetic	22681890
PUS2_SCHPO	pus2	genetic	22681890
PSK1_SCHPO	psk1	genetic	22681890
YQK8_SCHPO	SPCC1494.08c	genetic	22681890
APH1_SCHPO	aph1	genetic	22681890
SET1_SCHPO	set1	genetic	12589755

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HUS1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND MASSSPECTROMETRY.	18257517 [Abstract]