dbPTM

YEG3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YEG3_SCHPO
UniProt AC	O13985
Protein Name	Uncharacterized WD repeat-containing protein C26H5.03
Gene Name	SPAC26H5.03
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	512
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description
Protein Sequence	MRAEVLQIRWHYDANDDHTPIYSVDFQKNSLNKFATCGGDSKIRIWQLITSESSTKVEYLSTLSRHTQAVNVVRFNPEGNILATAGDEGTIMLWVPTNTPITTLADDAEELALAKEYWKVKIVCRSMGSEIYDLCWSVDSNFLIAGAMDNSLRLYDAHTGQLLTQKFDHSHYVQGVCWDPLNQYIVSESSDRSICLYEIQEEKKNPKKFQLVLKSRICRIEYNVTKFELISVTKPLNNDESSGISEPIETSNNNESPVSKHEALSSTANIVKDGSLERTEPPNSLNSKISYSLYCNETLVSFFRRPAFSPDGLLLVTPAGRLRPHGQPNFEVPYTAYIYTRGSITKQPVACLNGFKKPVIAVRFSPIHYELNSFSNFSFTSVSFNLPYRMVFAVACQDAVYIYDTQTCKPFYRAVNLHYSNLTDIAWNDDGNVLLMTSIDGFCSVITFEPGELGVKSQHKISLPEKRSASPSSIDDSQDNTAGGPATTTLIPRKVESSKVSKKRIAPTPVYP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
256	Phosphorylation	ETSNNNESPVSKHEA CCCCCCCCCCCHHHH	32.50	21712547
259	Phosphorylation	NNNESPVSKHEALSS CCCCCCCCHHHHHHH	31.51	24763107
468	Phosphorylation	ISLPEKRSASPSSID CCCCCCCCCCCCCCC	44.13	28889911
470	Phosphorylation	LPEKRSASPSSIDDS CCCCCCCCCCCCCCC	26.93	28889911
472	Phosphorylation	EKRSASPSSIDDSQD CCCCCCCCCCCCCCC	37.11	24763107
473	Phosphorylation	KRSASPSSIDDSQDN CCCCCCCCCCCCCCC	33.16	28889911
477	Phosphorylation	SPSSIDDSQDNTAGG CCCCCCCCCCCCCCC	35.37	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YEG3_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YEG3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YEG3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWI6_SCHPO	swi6	physical	18761674
YEC6_SCHPO	pcf3	physical	18761674
PCNA_SCHPO	pcn1	physical	18761674
RAD9_SCHPO	rad9	genetic	18818364
EME1_SCHPO	eme1	genetic	18818364
HIR1_SCHPO	hip1	genetic	18818364
HPC2_SCHPO	hip4	genetic	18818364
ABP1_SCHPO	cbp1	genetic	18818364
HAT1_SCHPO	hat1	genetic	22681890
FEN1_SCHPO	rad2	genetic	22681890
PFL4_SCHPO	pfl4	genetic	22681890
YA33_SCHPO	SPAC18B11.03c	genetic	22681890
ARGI1_SCHPO	car1	genetic	22681890
ADH4_SCHPO	adh4	genetic	22681890
YJ52_SCHPO	SPCP20C8.02c	genetic	22681890
YAC5_SCHPO	cph1	genetic	22681890
RAD55_SCHPO	rad55	genetic	22681890
THI5_SCHPO	thi5	genetic	22681890
YBPC_SCHPO	SPBC16H5.12c	genetic	22681890
RAD57_SCHPO	rad57	genetic	22681890
JHD1_SCHPO	epe1	genetic	22681890
ATG20_SCHPO	atg20	genetic	22681890
ELP3_SCHPO	elp3	genetic	22681890
HUS1_SCHPO	hus1	genetic	22681890
FKBP4_SCHPO	fkbp39	genetic	22681890
YGVA_SCHPO	def1	genetic	22681890
SET6_SCHPO	set6	genetic	22681890
YHZ7_SCHPO	SPBC21B10.07	genetic	22681890
YJ2D_SCHPO	SPCC4B3.13	genetic	22681890
MCL1_SCHPO	mcl1	genetic	22681890
HUS2_SCHPO	rqh1	genetic	25313826

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YEG3_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468; SER-470 ANDSER-473, AND MASS SPECTROMETRY.	18257517 [Abstract]