| UniProt ID | FEN1_SCHPO | |
|---|---|---|
| UniProt AC | P39750 | |
| Protein Name | Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140} | |
| Gene Name | rad2 {ECO:0000255|HAMAP-Rule:MF_03140} | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 380 | |
| Subcellular Localization | Nucleus, nucleolus . Nucleus, nucleoplasm . Mitochondrion . Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. | |
| Protein Description | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.. | |
| Protein Sequence | MGIKGLAQVLSEHAPASVKHNDIKNYFGRKVAIDASMSLYQFLIQVRSQDGQQLMNEQGETTSHLMGMFYRTLRIVDNGIKPCFVFDGKPPTLKSGELAKRVARHQKAREDQEETKEVGTAEMVDRFAKRTVKVTRQHNDEAKRLLELMGIPFVNAPCEAEAQCAALARSGKVYAAASEDMDTLCFQAPVLLRHLTFSEQRKEPISEYNIEKALNGLDMSVEQFVDLCILLGCDYCEPIRGVGPARAVELIRQYGTLDRFVKEADRSKYPIPEDWPYEDARRLFLDAEVLPGEEIELKWKSPDADGIIQFLVKEKGFNEDRVKLGINRLEKASKTIPQGRLDSFFKPVPSSPKKPVDTKSKGSAKRKRDSNKGGESKKKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 343 | Phosphorylation | IPQGRLDSFFKPVPS CCCCCCHHHCCCCCC | 36.86 | 21712547 | |
| 350 | Phosphorylation | SFFKPVPSSPKKPVD HHCCCCCCCCCCCCC | 60.55 | 28889911 | |
| 351 | Phosphorylation | FFKPVPSSPKKPVDT HCCCCCCCCCCCCCC | 34.37 | 28889911 | |
| 358 | Phosphorylation | SPKKPVDTKSKGSAK CCCCCCCCCCCCCCC | 37.13 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FEN1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FEN1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FEN1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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