| UniProt ID | UVE1_SCHPO | |
|---|---|---|
| UniProt AC | Q10988 | |
| Protein Name | UV-damage endonuclease | |
| Gene Name | uve1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 599 | |
| Subcellular Localization | ||
| Protein Description | Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway. Functions also in oxidative damage repair in vivo. Provides back-up AP endonuclease activity to apn2 together with apn1.. | |
| Protein Sequence | MLRLLKRNIQISKRIVFTILKQKAFKGNHPCVPSVCTITYSRFHCLPDTLKSLLPMSSKTTLSMLPQVNIGANSFSAETPVDLKKENETELANISGPHKKSTSTSTRKRARSSKKKATDSVSDKIDESVASYDSSTHLRRSSRSKKPVNYNSSSESESEEQISKATKKVKQKEEEEYVEEVDEKSLKNESSSDEFEPVVPEQLETPISKRRRSRSSAKNLEKESTMNLDDHAPREMFDCLDKPIPWRGRLGYACLNTILRSMKERVFCSRTCRITTIQRDGLESVKQLGTQNVLDLIKLVEWNHNFGIHFMRVSSDLFPFASHAKYGYTLEFAQSHLEEVGKLANKYNHRLTMHPGQYTQIASPREVVVDSAIRDLAYHDEILSRMKLNEQLNKDAVLIIHLGGTFEGKKETLDRFRKNYQRLSDSVKARLVLENDDVSWSVQDLLPLCQELNIPLVLDWHHHNIVPGTLREGSLDLMPLIPTIRETWTRKGITQKQHYSESADPTAISGMKRRAHSDRVFDFPPCDPTMDLMIEAKEKEQAVFELCRRYELQNPPCPLEIMGPEYDQTRDGYYPPGAEKRLTARKRRSRKEEVEEDEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 185 | Phosphorylation | VEEVDEKSLKNESSS HHHHCHHHHCCCCCC | 42.39 | 25720772 | |
| 190 | Phosphorylation | EKSLKNESSSDEFEP HHHHCCCCCCCCCCC | 44.53 | 25720772 | |
| 191 | Phosphorylation | KSLKNESSSDEFEPV HHHCCCCCCCCCCCC | 35.31 | 25720772 | |
| 192 | Phosphorylation | SLKNESSSDEFEPVV HHCCCCCCCCCCCCC | 50.90 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UVE1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UVE1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UVE1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SWI10_SCHPO | swi10 | genetic | 11800554 | |
| RAD13_SCHPO | rad13 | genetic | 10652237 | |
| RAD13_SCHPO | rad13 | genetic | 10390527 | |
| RAD13_SCHPO | rad13 | genetic | 9092661 | |
| HUS2_SCHPO | rqh1 | genetic | 9092661 | |
| RHP23_SCHPO | rhp23 | genetic | 10652237 | |
| APN2_SCHPO | apn2 | genetic | 14599746 | |
| RHP41_SCHPO | rhp41 | genetic | 12531030 | |
| CKN1_SCHPO | ckn1 | genetic | 18794354 | |
| WDR21_SCHPO | wdr21 | genetic | 18794354 | |
| RAD13_SCHPO | rad13 | genetic | 10446227 | |
| SAP1_SCHPO | sap1 | genetic | 17151242 | |
| RHP23_SCHPO | rhp23 | genetic | 12531030 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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