RHP23_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHP23_SCHPO
• UniProt AC: O74803
• Protein Name: UV excision repair protein rhp23
• Gene Name: rhp23
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 368
• Subcellular Localization: Nucleus .
• Protein Description: Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.; Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation..
• Protein Sequence: MNLTFKNLQQQKFVISDVSADTKISELKEKIQTQQNYEVERQKLIYSGRILADDKTVGEYNIKEQDFIVCMVSRPKTSTSTPKSAASPAPNPPASVPEKKVEAPSSTVAESTSTTQTVAAAAPSNPDTTATSEAPIDANTLAVGAQRNVAVENMVEMGYERSEVERAMRAAFNNPDRAVEYLLTGIPEDILNRQREESAAALAAQQQQSEALAPTSTGQPANLFEQAALSENENQEQPSNTVGDDPLGFLRSIPQFQQLRQIVQQNPQMLETILQQIGQGDPALAQAITQNPEAFLQLLAEGAEGESALPSGGIQIQITQEESESIDRLCQLGFDRNIVIQAYLACDKNEELAANYLFEHGHESEDEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	VSRPKTSTSTPKSAA EECCCCCCCCCCCCC	41.68	25720772
80	Phosphorylation	SRPKTSTSTPKSAAS ECCCCCCCCCCCCCC	42.34	25720772
81	Phosphorylation	RPKTSTSTPKSAASP CCCCCCCCCCCCCCC	34.52	25720772
84	Phosphorylation	TSTSTPKSAASPAPN CCCCCCCCCCCCCCC	30.21	28889911
87	Phosphorylation	STPKSAASPAPNPPA CCCCCCCCCCCCCCC	22.70	28889911
95	Phosphorylation	PAPNPPASVPEKKVE CCCCCCCCCCHHHCC	43.93	27738172
356	Phosphorylation	NEELAANYLFEHGHE CHHHHHHHHHHCCCC	14.19	21712547
364	Phosphorylation	LFEHGHESEDEP--- HHHCCCCCCCCC---	44.68	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHP23_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHP23_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHP23_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPN1_SCHPO	mts4	physical	12615927
CUT9_SCHPO	cut9	physical	12615927
RL401_SCHPO	ubi1	physical	11788722
RL402_SCHPO	ubi1	physical	11788722
RS27A_SCHPO	ubi3	physical	11788722
DSK2_SCHPO	dph1	physical	11788722
ATF1_SCHPO	atf1	physical	11584278
RPN1_SCHPO	mts4	physical	11584278
UBI4P_SCHPO	ubi4	physical	17211518
RPN1_SCHPO	mts4	physical	20614012
ATL1_SCHPO	atl1	genetic	22658721
UBI4P_SCHPO	ubi4	physical	23038266
PUS1_SCHPO	pus1	genetic	23038266
UBI4P_SCHPO	ubi4	physical	25306921

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-87 AND SER-364,AND MASS SPECTROMETRY.
PubMed: 18257517